Radiology, Vol 186, 107-115, Copyright © 1993 by Radiological Society of North America

ARTICLES

Morphologic effects of cigarette smoking on airways and pulmonary parenchyma in healthy adult volunteers: CT evaluation and correlation with pulmonary function tests

M Remy-Jardin, J Remy, C Boulenguez, A Sobaszek, JL Edme and D Furon
Department of Radiology, Hopital Calmette CHRU de Lille, France.

A prospective computed tomographic (CT) study was performed to determine the prevalence of lung changes in smokers. The study group comprised 175 healthy adult volunteers (current smokers, n = 98; ex- smokers, n = 26; nonsmokers, n = 51). The subjects underwent clinical examination, pulmonary function tests, chest radiography, and conventional and high-resolution CT (HRCT). Significant differences between current smokers, ex-smokers, and nonsmokers were observed with HRCT in the identification of subpleural (P = .11) and parenchymal (P < .001) micronodules, emphysema (P < .001), and areas of ground-glass attenuation (P = .0001). All subjects had normal pulmonary function. Parenchymal micronodules, areas of ground-glass attenuation, and emphysema were observed with a significant predominance in the upper lung zones (P < .01). Presence of emphysema and abnormal bronchial wall thickening were the only HRCT signs associated with significantly lower values of functional parameters. These data support the concept that parenchymal abnormalities can be detected in healthy smokers with normal findings at chest radiography and pulmonary function tests.

This article has been cited by other articles:

				A. U Wells, A. G Nicholson, and D. M Hansell Challenges in pulmonary fibrosis {middle dot} 4: Smoking-induced diffuse interstitial lung diseases Thorax, October 1, 2007; 62(10): 904 - 910. [Abstract] [Full Text] [PDF]

				C. Mueller-Mang, C. Grosse, K. Schmid, L. Stiebellehner, and A. A. Bankier What Every Radiologist Should Know about Idiopathic Interstitial Pneumonias RadioGraphics, May 1, 2007; 27(3): 595 - 615. [Abstract] [Full Text] [PDF]

				M. Nakanishi, Y. Demura, S. Mizuno, S. Ameshima, Y. Chiba, I. Miyamori, H. Itoh, M. Kitaichi, and T. Ishizaki Changes in HRCT findings in patients with respiratory bronchiolitis-associated interstitial lung disease after smoking cessation Eur. Respir. J., March 1, 2007; 29(3): 453 - 461. [Abstract] [Full Text] [PDF]

				N. A. Sibtain, M. Ujita, R. Wilson, A. U. Wells, and D. M. Hansell Interlobular Septal Thickening in Idiopathic Bronchiectasis: A Thin-Section CT Study of 94 Patients Radiology, December 1, 2005; 237(3): 1091 - 1096. [Abstract] [Full Text] [PDF]

				C. E. Girod and T. E. King Jr. COPD: A Dust-Induced Disease? Chest, October 1, 2005; 128(4): 3055 - 3064. [Abstract] [Full Text] [PDF]

				J. H. Ryu, J. L. Myers, S. A. Capizzi, W. W. Douglas, R. Vassallo, and P. A. Decker Desquamative Interstitial Pneumonia and Respiratory Bronchiolitis-Associated Interstitial Lung Disease Chest, January 1, 2005; 127(1): 178 - 184. [Abstract] [Full Text] [PDF]

				N J Screaton and T Koh Emphysema and smoking-related lung diseases Imaging, October 1, 2004; 16(1): 50 - 60. [Abstract] [Full Text] [PDF]

				J. Zhang, I. Hasegawa, H. Hatabu, D. Feller-Kopman, and P. M. Boiselle Frequency and Severity of Air Trapping at Dynamic Expiratory CT in Patients with Tracheobronchomalacia Am. J. Roentgenol., January 1, 2004; 182(1): 81 - 85. [Abstract] [Full Text] [PDF]

				J. H. Ryu, J. L. Myers, and S. J. Swensen Bronchiolar Disorders Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1277 - 1292. [Abstract] [Full Text] [PDF]

				T. Vehmas, L. Kivisaari, M.S. Huuskonen, and M.S. Jaakkola Effects of tobacco smoking on findings in chest computed tomography among asbestos-exposed workers Eur. Respir. J., May 1, 2003; 21(5): 866 - 871. [Abstract] [Full Text] [PDF]

				S. Matsuoka, K. Uchiyama, H. Shima, N. Ueno, S. Oish, and Y. Nojiri Bronchoarterial Ratio and Bronchial Wall Thickness on High-Resolution CT in Asymptomatic Subjects: Correlation with Age and Smoking Am. J. Roentgenol., February 1, 2003; 180(2): 513 - 518. [Abstract] [Full Text] [PDF]

				K. D. Clark, N. Wardrobe-Wong, J. J. Elliott, P. T. Gill, N. P. Tait, and P. D. Snashall Patterns of Lung Disease in a "Normal" Smoking Population : Are Emphysema and Airflow Obstruction Found Together? Chest, September 1, 2001; 120(3): 743 - 747. [Abstract] [Full Text] [PDF]

				E. A. Kazerooni High-Resolution CT of the Lungs Am. J. Roentgenol., September 1, 2001; 177(3): 501 - 519. [Full Text] [PDF]

				D.M. Hansell Small airways diseases: detection and insights with computed tomography Eur. Respir. J., June 1, 2001; 17(6): 1294 - 1313. [Abstract] [Full Text] [PDF]

				J.H. Ryu, T.V. Colby, T.E. Hartman, and R. Vassallo Smoking-related interstitial lung diseases: a concise review Eur. Respir. J., January 1, 2001; 17(1): 122 - 132. [Abstract] [Full Text] [PDF]

				O. Lucidarme, P. A. Grenier, M. Cadi, I. Mourey-Gerosa, K. Benali, and P. Cluzel Evaluation of Air Trapping at CT: Comparison of Continuous- versus Suspended-Expiration CT Techniques Radiology, September 1, 2000; 216(3): 768 - 772. [Abstract] [Full Text]

				K. SOEJIMA, K. YAMAGUCHI, E. KOHDA, K. TAKESHITA, Y. ITO, H. MASTUBARA, T. OGUMA, T. INOUE, Y. OKUBO, K. AMAKAWA, et al. Longitudinal Follow-up Study of Smoking-induced Lung Density Changes by High-resolution Computed Tomography Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1264 - 1273. [Abstract] [Full Text]

				K. W. Lee, S. Y. Chung, I. Yang, Y. Lee, E. Y. Ko, and M. J. Park Correlation of Aging and Smoking with Air Trapping at Thin-Section CT of the Lung in Asymptomatic Subjects Radiology, March 1, 2000; 214(3): 831 - 836. [Abstract] [Full Text]

				J. Moon, R. M du Bois, T. V Colby, D. M Hansell, and A. G Nicholson Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease Thorax, November 1, 1999; 54(11): 1009 - 1014. [Abstract] [Full Text]

				K. D. CLARK, N. WARDROBE-WONG, and P. D. SNASHALL Endogenous Cortisol and Lung Damage in a Predominantly Smoking Population Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 755 - 759. [Abstract] [Full Text]

				M. Remy-Jardin, J.-L. Edme, C. Boulenguez, J. Remy, I. Mastora, and A. Sobaszek Longitudinal Follow-up Study of Smoker's Lung with Thin-Section CT in Correlation with Pulmonary Function Tests Radiology, January 1, 2002; 222(1): 261 - 270. [Abstract] [Full Text] [PDF]