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Radiology, Vol 186, 795-798, Copyright © 1993 by Radiological Society of North America

ARTICLES

Mn-DPDP in MR imaging of pancreatic adenocarcinoma: initial clinical experience

HB Gehl, R Urhahn, K Bohndorf, P Klever, S Hauptmann, KP Lodemann, S Matern, V Schumpelick and RW Gunther
Department of Diagnostic Radiology, Technical University of Aachen, Germany.

Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'- bis(phosphate) (DPDP) was tested as a contrast agent for magnetic resonance imaging of pancreatic adenocarcinoma in 15 patients. At enhanced T1-weighted spin-echo (SE) and enhanced T1-weighted gradient- echo (GRE) imaging, statistically significant increases in signal-to- noise ratio (S/N) for the pancreas (21% and 92%, respectively) and contrast-to-noise ratio (C/N) (91% and 209%, respectively) were found. The C/N at enhanced T1-weighted SE imaging was superior to that at unenhanced imaging, including T2-weighted SE imaging (P = .001). Subjective image analysis showed that delineation of the pancreas and pancreatic tumors was clearly improved (P = .05) on enhanced T1- weighted SE and GRE images compared with on unenhanced T1- and T2- weighted images. The liver enhanced 19% at T1-weighted SE imaging and 90% at T1-weighted GRE imaging. There was a significantly higher S/N increase in hepatic parenchyma than in pancreatic tissue at enhanced T1- weighted GRE imaging (P = .0026) but not at enhanced T1-weighted SE imaging.


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