Radiology, Vol 187, 95-98, Copyright © 1993 by Radiological Society of North America
Early-stage breast cancer: local control after conservative surgery and radiation therapy with immediate interstitial boost
L Krishnan, WR Jewell, CM Mansfield, EK Reddy, JH Thomas and EC Krishnan
Department of Radiation Oncology, University of Kansas Medical Center, Kansas City 66160.
Two hundred forty-five women (250 breasts) with early-stage breast cancer
were treated between June 1982 and June 1990 with lumpectomy, immediate
(boost) interstitial iridium-192 to 15-20 Gy, and external- beam
irradiation to the entire breast to 45-50 Gy. There were 123 stage I
cancers (T1N0M0), 123 stage II cancers (36 T1N1, 50 T2N0, 33 T2N1, four
T3N0), and four stage III cancers (two T2N2, two T3N1). At a median
follow-up of 69 months (range, 26-122 months), there were 14 recurrences in
the treated breasts. Four were at the site of primary disease, eight were
in other quadrants, and two were in both. With immediate interstitial
boost, the 11-year actuarial recurrence rate in the breast is 7.7% and the
recurrence rate at the site of primary disease is 3.2%.
