Radiology, Vol 187, 449-458, Copyright © 1993 by Radiological Society of North America

ARTICLES

Cerebral perfusion in children: detection with dynamic contrast- enhanced T2*-weighted MR images

AA Tzika, RJ Massoth, WS Ball Jr, S Majumdar, RS Dunn and DR Kirks
Department of Radiology, Children's Hospital Medical Center, Cincinnati, Ohio.

Cerebral perfusion dynamics were assessed with dynamic contrast material-enhanced T2*-weighted magnetic resonance (MR) imaging in 33 subjects aged 3-20 years. Group A (n = 20) had sickle cell anemia without clinical evidence of cerebrovascular disease. Group B (n = 13) consisted of 12 patients with cerebrovascular disease and homozygous sickle cell anemia and one patient without that anemia. All subjects underwent conventional MR imaging and a dynamic study in which a spoiled gradient-echo pulse sequence was used to generate images (acquisition time, 2.5 seconds) during injection of a compact bolus of gadopentetate dimeglumine (0.1 mmol/kg). For qualitative analysis, the dynamic images were displayed in cine mode. Group A demonstrated symmetric sequential region patterns of loss of signal intensity within 10 seconds of injection. Group B exhibited signal loss asymmetries that corresponded to cerebrovascular lesions on conventional MR images. Quantitative analysis enabled estimation of hemodynamic parameters, including relative cerebral blood volume, relative cerebral blood flow, and mean transit time. This method of assessment of cerebral perfusion dynamics complements conventional MR imaging.

This article has been cited by other articles:

				R. Grueneich, M. D. Ris, W. Ball, K. A. Kalinyak, R. Noll, K. Vannatta, and R. Wells Relationship of Structural Magnetic Resonance Imaging, Magnetic Resonance Perfusion, and Other Disease Factors to Neuropsychological Outcome in Sickle Cell Disease J. Pediatr. Psychol., March 1, 2004; 29(2): 83 - 92. [Abstract] [Full Text] [PDF]

				K. Yamada, O. Wu, R. G. Gonzalez, D. Bakker, L. Ostergaard, W. A. Copen, R. M. Weisskoff, B. R. Rosen, K. Yagi, T. Nishimura, et al. Magnetic Resonance Perfusion-Weighted Imaging of Acute Cerebral Infarction: Effect of the Calculation Methods and Underlying Vasculopathy Stroke, January 1, 2002; 33(1): 87 - 94. [Abstract] [Full Text] [PDF]

				R. Bruening, C. Berchtenbreiter, N. Holzknecht, M. Essig, R. H. Wu, A. Simmons, A. Heuck, A. Maschek, M. Meusel, S. C. R. Williams, et al. Effects of Three Different Doses of a Bolus Injection of Gadodiamide: Assessment of Regional Cerebral Blood Volume Maps in a Blinded Reader Study AJNR Am. J. Neuroradiol., October 1, 2000; 21(9): 1603 - 1610. [Abstract] [Full Text]

				T. Sheth, Ichise, and Kucharczyk Brain Perfusion Imaging in Asymptomatic Patients Receiving AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 853 - 856. [Abstract] [Full Text]

				M. Maeda, W. T. C. Yuh, T. Ueda, J. E. Maley, D. L. Crosby, M.-W. Zhu, and V. A. Magnotta Severe Occlusive Carotid Artery Disease: Hemodynamic Assessment by MR Perfusion Imaging in Symptomatic Patients AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 43 - 51. [Abstract] [Full Text]

				N. Nighoghossian, Y. Berthezene, B. Philippon, P. Adeleine, J.C. Froment, and P. Trouillas Hemodynamic Parameter Assessment With Dynamic Susceptibility Contrast Magnetic Resonance Imaging in Unilateral Symptomatic Internal Carotid Artery Occlusion Stroke, March 1, 1996; 27(3): 474 - 479. [Abstract] [Full Text]

				T. B. Muller, O. Haraldseth, R. A. Jones, G. Sebastiani, C. F. Lindboe, G. Unsgard, and A. N. Oksendal Perfusion and Diffusion-Weighted MR Imaging for In Vivo Evaluation of Treatment With U74389G in a Rat Stroke Model Stroke, August 1, 1995; 26(8): 1453 - 1458. [Abstract] [Full Text]