| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Radiology, Vol 188, 119-124, Copyright © 1993 by Radiological Society of North America
ARTICLES |
WK Chong, B Sweeney, ID Wilkinson, M Paley, MA Hall-Craggs, BE Kendall, JK Shepard, M Beecham, RF Miller and IV Weller
MR Unit, Middlesex Hospital, London, England.
Abnormalities at cerebral proton spectroscopy occur in patients with the acquired immunodeficiency syndrome (AIDS). N-acetyl aspartate (NAA) is believed to be a neuronal marker, and neuronal loss is thought to underlie the human immunodeficiency virus (HIV)-associated cognitive/motor complex. The proton spectra in 103 HIV-seropositive patients and 23 control subjects were compared and correlated with clinical, immunologic, and radiologic measures of HIV infection. Significant (P < .05) reductions in the mean NAA/choline (Cho) and NAA/creatine (Cr) ratios were seen in patients with immune suppression and neurologic signs. Significant increases in the Cho/Cr ratios were seen in patients with low CD4 lymphocyte counts and abnormal magnetic resonance (MR) images. Reduced NAA ratios correlated with diffuse but not focal MR imaging abnormalities. Combined MR imaging and spectroscopy provides closer relationships to clinical and immunologic measures of disease than either modality alone. Spectroscopy is an adjunct to MR imaging and augments the value of an MR imaging study.
This article has been cited by other articles:
|
|
 |
|
  A. C. Roc, B. M. Ances, S. Chawla, M. Korczykowski, R. L. Wolf, D. L. Kolson, J. A. Detre, and H. Poptani Detection of Human Immunodeficiency Virus Induced Inflammation and Oxidative Stress in Lenticular Nuclei With Magnetic Resonance Spectroscopy Despite Antiretroviral Therapy Arch Neurol, September 1, 2007; 64(9): 1249 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Paul, C. T. Yiannoutsos, E. N. Miller, L. Chang, C. M. Marra, G. Schifitto, T. Ernst, E. Singer, T. Richards, G. J. Jarvik, et al. Proton MRS and Neuropsychological Correlates in AIDS Dementia Complex: Evidence of Subcortical Specificity J Neuropsychiatry Clin Neurosci, August 1, 2007; 19(3): 283 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Jernigan, A. C. Gamst, S. L. Archibald, C. Fennema-Notestine, M. R. Mindt, T. L. Marcotte, R. K. Heaton, R. J. Ellis, and I. Grant Effects of Methamphetamine Dependence and HIV Infection on Cerebral Morphology Am J Psychiatry, August 1, 2005; 162(8): 1461 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Lentz, J. P. Kim, S. V. Westmoreland, J. B. Greco, R. A. Fuller, E. M. Ratai, J. He, P. K. Sehgal, E. F. Halpern, A. A. Lackner, et al. Quantitative Neuropathologic Correlates of Changes in Ratio of N-acetylaspartate to Creatine in Macaque Brain Radiology, May 1, 2005; 235(2): 461 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Keller, T. N. Venkatraman, A. Thomas, A. Deveikis, C. LoPresti, J. Hayes, N. Berman, I. Walot, S. Padilla, J. Johnston-Jones, et al. Altered neurometabolite development in HIV-infected children: Correlation with neuropsychological tests Neurology, May 25, 2004; 62(10): 1810 - 1817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Patel, M. Inglese, G. Glosser, D. L. Kolson, R. I. Grossman, and O. Gonen Whole-Brain N-Acetylaspartate Level and Cognitive Performance in HIV Infection AJNR Am. J. Neuroradiol., September 1, 2003; 24(8): 1587 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Wenserski, H.-J. von Giesen, H.-J. Wittsack, A. Aulich, and G. Arendt Human Immmunodeficiency Virus 1-associated Minor Motor Disorders: Perfusion-weighted MR Imaging and H MR Spectroscopy Radiology, July 1, 2003; 228(1): 185 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Hurley, T. Ernst, K. Khalili, L. Del Valle, I. L. Simone, and K. H. Taber Identification of HIV-Associated Progressive Multifocal Leukoencephalopathy: Magnetic Resonance Imaging and Spectroscopy J Neuropsychiatry Clin Neurosci, February 1, 2003; 15(1): 1 - 6. [Full Text] [PDF]
|
|
|
|
|
|
H.-J. von Giesen, H.-J. Wittsack, F. Wenserski, H. Koller, H. Hefter, and G. Arendt Basal Ganglia Metabolite Abnormalities in Minor Motor Disorders Associated With Human Immunodeficiency Virus Type 1 Arch Neurol, August 1, 2001; 58(8): 1281 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C A Davie, N C Silver, G J Barker, P S Tofts, A J Thompson, W I McDonald, and D H Miller Does the extent of axonal loss and demyelination from chronic lesions in multiple sclerosis correlate with the clinical subgroup? J. Neurol. Neurosurg. Psychiatry, December 1, 1999; 67(6): 710 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chang, T. Ernst, M. Leonido-Yee, M. Witt, O. Speck, I. Walot, and E. N. Miller Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia Neurology, September 1, 1999; 53(4): 782 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Meyerhoff, C. Bloomer, V. Cardenas, D. Norman, M. W. Weiner, and G. Fein Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV patients Neurology, March 1, 1999; 52(5): 995 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chang, T. Ernst, M. Leonido-Yee, I. Walot, and E. Singer Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex Neurology, January 1, 1999; 52(1): 100 - 100. [Abstract] [Full Text]
|
|
|
|
|
|
M J G Harrison, S P Newman, M A Hall-Craggs, C J Fowler, R Miller, B E Kendall, M Paley, I Wilkinson, B Sweeney, S Lunn, et al. Evidence of CNS impairment in HIV infection: clinical, neuropsychological, EEG, and MRI/MRS study J. Neurol. Neurosurg. Psychiatry, September 1, 1998; 65(3): 301 - 307. [Abstract] [Full Text]
|
|
|
|
|
|
I L Simone, F Federico, C Tortorella, C F Andreula, G B Zimatore, P Giannini, G Angarano, V Lucivero, P Picciola, D Carrara, et al. Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV J. Neurol. Neurosurg. Psychiatry, April 1, 1998; 64(4): 516 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C A Davie, G J Barker, A J Thompson, P S Tofts, W I McDonald, and D H Miller 1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, December 1, 1997; 63(6): 736 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. D Wilkinson, S. Lunn, K. A Miszkiel, R. F Miller, M. N J Paley, I. Williams, R. J S Chinn, M. A Hall-Craggs, S. P Newman, B. E Kendall, et al. Proton MRS and quantitative MRI assessment of the short term neurological response to antiretroviral therapy in AIDS J. Neurol. Neurosurg. Psychiatry, October 1, 1997; 63(4): 477 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lopez-Villegas, R. E. Lenkinski, and I. Frank Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy PNAS, September 2, 1997; 94(18): 9854 - 9859. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
