Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takikawa, S.
Right arrow Articles by Eidelberg, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takikawa, S.
Right arrow Articles by Eidelberg, D.

Radiology, Vol 188, 131-136, Copyright © 1993 by Radiological Society of North America

ARTICLES

Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve

S Takikawa, V Dhawan, P Spetsieris, W Robeson, T Chaly, R Dahl, D Margouleff and D Eidelberg
Department of Neurology, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.

The authors have developed a technique to estimate input functions from a population-based arterial blood curve in positron emission tomography (PET) studies with fluorine-18 fluorodeoxyglucose (FDG). A standardized pump injection was used in 34 subjects. A population-based blood curve was generated based on the first 10 subjects. In the remaining 24 subjects, an estimated input function (EIFa) was obtained by scaling the population-based curve with two arterial blood samples, one obtained at 10 minutes and the other at 45. Time integrals for EIFa and the real arterial input function (RIF) were in excellent agreement (r = .998, P < .0001). Cerebral metabolic rates for glucose calculated with EIFa and RIF and the autoradiographic method also correlated excellently (r = .992, P < .0001). Analogous correlations were achieved with arterialized venous samples as scaling factors. These results suggest that individually scaled, population-derived input functions may serve as an adequate alternative to continuous arterial blood sampling in quantitative FDG-PET imaging.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. A. Deadwyler, L. Porrino, J. M. Siegel, and R. E. Hampson
Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates
J. Neurosci., December 26, 2007; 27(52): 14239 - 14247.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Feigin, C. Tang, Y. Ma, P. Mattis, D. Zgaljardic, M. Guttman, J. S. Paulsen, V. Dhawan, and D. Eidelberg
Thalamic metabolism and symptom onset in preclinical Huntington's disease
Brain, November 1, 2007; 130(11): 2858 - 2867.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
T. Schroeder, M. F. Vidal Melo, G. Musch, R. S. Harris, J. G. Venegas, and T. Winkler
Image-Derived Input Function for Assessment of 18F-FDG Uptake by the Inflamed Lung
J. Nucl. Med., November 1, 2007; 48(11): 1889 - 1896.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Huang, C. Tang, A. Feigin, M. Lesser, Y. Ma, M. Pourfar, V. Dhawan, and D. Eidelberg
Changes in network activity with the progression of Parkinson's disease
Brain, July 1, 2007; 130(7): 1834 - 1846.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
W. K. Schiffer, M. M. Mirrione, and S. L. Dewey
Optimizing Experimental Protocols for Quantitative Behavioral Imaging with 18F-FDG in Rodents
J. Nucl. Med., February 1, 2007; 48(2): 277 - 287.
[Abstract] [Full Text] [PDF]

Home page
 AJGPHome page
G. S. Smith, E. Kramer, C. R. Hermann, S. Goldberg, Y. Ma, V. Dhawan, A. Barnes, T. Chaly, A. Belakhleff, F. Laghrissi-Thode, et al.
Acute and Chronic Effects of Citalopram on Cerebral Glucose Metabolism in Geriatric Depression
Am J Geriatr Psychiatry, December 1, 2002; 10(6): 715 - 723.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Feigin, M. Fukuda, V. Dhawan, S. Przedborski, V. Jackson-Lewis, M.J. Mentis, J.R. Moeller, and D. Eidelberg
Metabolic correlates of levodopa response in Parkinson's disease
Neurology, December 11, 2001; 57(11): 2083 - 2088.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Fukuda, M. J. Mentis, Y. Ma, V. Dhawan, A. Antonini, A. E. Lang, A. M. Lozano, J. Hammerstad, K. Lyons, W. C. Koller, et al.
Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease: A PET study of resting-state glucose metabolism
Brain, August 1, 2001; 124(8): 1601 - 1609.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
T. Shiozaki, N. Sadato, M. Senda, K. Ishii, T. Tsuchida, Y. Yonekura, H. Fukuda, and J. Konishi
Noninvasive Estimation of FDG Input Function for Quantification of Cerebral Metabolic Rate of Glucose: Optimization and Multicenter Evaluation
J. Nucl. Med., October 1, 2000; 41(10): 1612 - 1618.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. Bisaga, J. L. Katz, A. Antonini, C. E. Wright, C. Margouleff, J. M. Gorman, and D. Eidelberg
Cerebral Glucose Metabolism in Women With Panic Disorder
Am J Psychiatry, September 1, 1998; 155(9): 1178 - 1183.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1993 by the Radiological Society of North America.