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Radiology, Vol 188, 669-673, Copyright © 1993 by Radiological Society of North America

ARTICLES

Waldenstrom macroglobulinemia: MR imaging of the spine and CT of the abdomen and pelvis

LA Moulopoulos, MA Dimopoulos, DG Varma, JT Manning, DA Johnston, NE Leeds and HI Libshitz
Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston 77030.

Twenty-three consecutive patients with Waldenstrom macroglobulinemia were studied with magnetic resonance (MR) imaging of the spine and computed tomography (CT) of the abdomen and pelvis. MR imaging studies included sagittal T1-weighted and gradient-recalled-echo sequences performed with and without contrast material enhancement. Marrow involvement was identified with MR imaging in 21 of 23 (91%) patients. Diffuse involvement was noted in 13 patients (56%), and a variegated pattern in eight (35%). CT demonstrated enlarged nodes in 10 of 23 (43%) patients. Correlation of MR imaging patterns and presence of adenopathy at CT with standard laboratory values for Waldenstrom macroglobulinemia revealed an association of the diffuse MR imaging pattern of marrow involvement and the presence of enlarged nodes at CT with more advanced disease. MR imaging of the spine and CT are reliable means of evaluation of disease status in Waldenstrom macroglobulinemia. They may be employed as additional means in the staging of Waldenstrom macroglobulinemia and may be helpful in the follow-up of patients with this rare hematologic malignancy.


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