Radiology, Vol 189, 429-432, Copyright © 1993 by Radiological Society of North America

ARTICLES

Natural history of fundic gland polyposis without familial adenomatosis coli: follow-up observations in 31 patients

K Hizawa, M Iida, T Matsumoto, K Aoyagi, T Yao and M Fujishima
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

PURPOSE: To clarify the natural history of fundic gland polyposis (FGP) without familial adenomatosis coli (FAC). MATERIALS AND METHODS: Thirty- one FGP patients without FAC (six men and 25 women) were followed up with radiography and endoscopy for 1-13 years (mean, 4.3 years). RESULTS: In eight of 11 patients who initially had a single polyp, the polyp disappeared, probably due to endoscopic forceps biopsy. Of 20 patients with multiple polyps, seven (one man and six women with a mean age of 40.6 years at initial diagnosis) had obvious changes in the number of polyps, including complete disappearance in three patients, a decrease in one, transient disappearance followed by recurrence in two, and an increase in one. These patients were younger and had a greater number of polyps at initial diagnosis than the remaining 16 patients without any remarkable change. CONCLUSION: FGP without FAC is characterized by spontaneous decrease or increase in the number of polyps, especially in middle-aged female patients with a large number of polyps.

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