Radiology, Vol 189, 609-613, Copyright © 1993 by Radiological Society of North America
Isolated vaginal recurrences of endometrial carcinoma
JD Morgan 3d, S Reddy, P Sarin, E Yordan, K DeGeest and FR Hendrickson
Department of Radiation Oncology, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612.
PURPOSE: The authors undertook this study to evaluate the results of
radiation therapy (RT) for vaginal recurrence in early stage endometrial
carcinoma. MATERIALS AND METHODS: Between 1964 and 1987, 34 patients with
isolated vaginal recurrences of endometrial carcinoma were treated with RT.
The records were reviewed for outcome and prognostic factors, such as
location of tumor recurrence, time to recurrence, size of tumor at
recurrence, tumor differentiation, and total radiation dose delivered at
RT. RESULTS: With a median follow-up of 48 months, the 5-year actuarial
survival and disease-free survival rates were 68% +/- 4 and 60% +/- 3,
respectively. Results were statistically significant for some prognostic
factors, including time to tumor recurrence and total radiation dose
delivered at RT to the recurring tumor. CONCLUSION: Long-term survival can
be obtained for patients with an isolated vaginal recurrence of endometrial
cancer treated with aggressive local-regional radiation therapy.
