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Radiology, Vol 190, 753-758, Copyright © 1994 by Radiological Society of North America

ARTICLES

MR imaging evaluation of liver enhancement by Gd-EOB-DTPA in selective and total bile duct obstruction in rats: correlation with serologic, microcholangiographic, and histologic findings

Y Ni, G Marchal, G Lukito, J Yu, A Muhler and AL Baert
Department of Radiology, University Hospitals K.U. Leuven, Belgium.

PURPOSE: To investigate the behavior and potential application of the hepatobiliary magnetic resonance (MR) imaging contrast agent gadolinium- ethoxybenzyl (EOB)-diethylene-triamine-pentaacetic acid (DTPA) in cholestasis. MATERIALS AND METHODS: Rat models of selective biliary obstruction (SBO) (n = 20) and total biliary obstruction (TBO) (n = 14) were used. Serial Gd-EOB-DTPA-enhanced MR images were obtained, and the findings were correlated with serologic, microcholangiographic, and histologic findings. RESULTS: In SBO rats, statistically significantly prolonged enhancement of ligated lobes occurred during the acute phase (P < .01) but was absent during the chronic phase owing to bile collateral vessels. In TBO rats, statistically significantly lower liver enhancement (P < .01) was observed as long as the obstruction persisted, until collateral bile ducts developed. CONCLUSION: The distinction between obstructed and unobstructed liver on Gd-EOB-DTPA- enhanced MR images suggests a novel application for visualizing cholestasis.


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