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Radiology, Vol 190, 835-840, Copyright © 1994 by Radiological Society of North America

ARTICLES

Beryllium disease: assessment with CT

LS Newman, DL Buschman, JD Newell Jr and DA Lynch
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

PURPOSE: To describe the thin-section computed tomographic (CT) features of beryllium disease and compare the sensitivities of thin- section CT and chest radiography. MATERIALS AND METHODS: In 28 patients with biopsy-proved beryllium disease and 12 healthy control subjects, radiographs were scored with an international classification system. Thin-section CT scans were scored for 11 parenchymal, airway, pleural, and mediastinal findings. RESULTS: Thin-section CT revealed at least one abnormality in 25 patients (89%); chest radiography, in 15 patients (54%). After the finding of bronchial wall thickening attributable to tobacco smoking was excluded, CT scans in 21 (75%) of 28 patients were abnormal because of beryllium disease. The most common CT abnormalities were parenchymal nodules (n = 16) and septal lines (n = 14). With use of CT, abnormalities were detected in 10 (77%) of 13 patients with normal radiographs. CONCLUSION: Thin-section CT was more sensitive than chest radiography in detection of beryllium disease, but the diagnosis was missed in up to 25% of cases with histologic proof.


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