Radiology, Vol 194, 101-105, Copyright © 1995 by Radiological Society of North America

ARTICLES

Early hepatocellular carcinoma: appearance at CT during arterial portography and CT arteriography with pathologic correlation

K Takayasu, Y Muramatsu, H Furukawa, F Wakao, N Moriyama, T Takayama, S Yamasaki, M Sakamoto and S Hirohashi
Department of Radiology, National Cancer Center Hospital, Tokyo, Japan.

PURPOSE: To use computed tomography (CT) during arterial portography (CTAP) and CT arteriography to compare the hemodynamic properties of early hepatocellular carcinoma (HCC) with those of small HCC. MATERIALS AND METHODS: Forty-four early HCCs (mean diameter, 1.5 cm) in 37 patients (26 men and 11 women aged 52-74 years; mean age, 59.2 years) were studied. CTAP was performed on 35 early HCCs, CT arteriography on 20, and both studies on 11. CTAP, CT arteriography, or both were performed on 90 small HCCs (mean diameter, 2.0 cm) in 57 patients (44 men and 13 women aged 48-71 years; mean age, 61 years). The findings for small HCC were compared with those for early HCC. RESULTS: CTAP depicted 23 early HCCs as hypoattenuating masses and 12 as isoattenuating. CT arteriography depicted 11 early HCCs as hypoattenuating masses, six as isoattenuating, and three as hyperattenuating. CTAP depicted 85 of 88 small HCCs as hypoattenuating masses and three as isoattenuating. CT arteriography depicted 13 of 14 small HCCs as hyperattenuating masses. CONCLUSION: CTAP, the standard of reference for the detection of small HCC, is not sensitive enough for the detection of early HCC.

This article has been cited by other articles:

				G-J Liu, H-X Xu, M-D Lu, X-Y Xie, Z-F Xu, Y-L Zheng, and J-Y Liang Correlation between enhancement pattern of hepatocellular carcinoma on real-time contrast-enhanced ultrasound and tumour cellular differentiation on histopathology Br. J. Radiol., May 1, 2007; 80(953): 321 - 330. [Abstract] [Full Text] [PDF]

				K. Takayasu, Y. Muramatsu, Y. Mizuguchi, T. Okusaka, K. Shimada, T. Takayama, and M. Sakamoto CT Evaluation of the progression of hypoattenuating nodular lesions in virus-related chronic liver disease. Am. J. Roentgenol., August 1, 2006; 187(2): 454 - 463. [Abstract] [Full Text] [PDF]

				C-S Li, R-C Chen, H-Y Tu, L-S Shih, T-A Zhang, J-M Lii, W-T Chen, S-J Duh, and L-C Chiang Imaging well-differentiated hepatocellular carcinoma with dynamic triple-phase helical computed tomography Br. J. Radiol., August 1, 2006; 79(944): 659 - 665. [Abstract] [Full Text] [PDF]

				R. Shinmura, O. Matsui, S. Kobayashi, N. Terayama, J. Sanada, K. Ueda, T. Gabata, M. Kadoya, and S. Miyayama Cirrhotic Nodules: Association between MR Imaging Signal Intensity and Intranodular Blood Supply Radiology, November 1, 2005; 237(2): 512 - 519. [Abstract] [Full Text] [PDF]

				A. Furuta, K. Ito, T. Fujita, S. Koike, A. Shimizu, and N. Matsunaga Hepatic Enhancement in Multiphasic Contrast-Enhanced MDCT: Comparison of High- and Low-Iodine-Concentration Contrast Medium in Same Patients with Chronic Liver Disease Am. J. Roentgenol., July 1, 2004; 183(1): 157 - 162. [Abstract] [Full Text] [PDF]

				K. H. Y. Lee, M. E. O'Malley, M. A. Haider, and A. Hanbidge Triple-Phase MDCT of Hepatocellular Carcinoma Am. J. Roentgenol., March 1, 2004; 182(3): 643 - 649. [Abstract] [Full Text] [PDF]

				I. E. Steingruber, A. Mallouhi, B. V. Czermak, P. Waldenberger, E. Gassner, F. Offner, A. Chemelli, A. Koenigsrainer, W. Vogel, and W. R. Jaschke Pretransplantation Evaluation of the Cirrhotic Liver with Explantation Correlation: Accuracy of CT Arterioportography and Digital Subtraction Hepatic Angiography in Revealing Hepatocellular Carcinoma Am. J. Roentgenol., July 1, 2003; 181(1): 99 - 108. [Abstract] [Full Text] [PDF]

				M. Hayashi, O. Matsui, K. Ueda, Y. Kawamori, T. Gabata, and M. Kadoya Progression to Hypervascular Hepatocellular Carcinoma: Correlation with Intranodular Blood Supply Evaluated with CT during Intraarterial Injection of Contrast Material Radiology, October 1, 2002; 225(1): 143 - 149. [Abstract] [Full Text] [PDF]

				H. C. Kim, T. K. Kim, K.-B. Sung, H.-K. Yoon, P. N. Kim, H. K. Ha, A. Y. Kim, H. J. Kim, and M.-G. Lee CT during Hepatic Arteriography and Portography: An Illustrative Review RadioGraphics, September 1, 2002; 22(5): 1041 - 1051. [Abstract] [Full Text] [PDF]

				J. H. Lim, D. Choi, S. H. Kim, S. J. Lee, W. J. Lee, H. K. Lim, and S. Kim Detection of Hepatocellular Carcinoma: Value of Adding Delayed Phase Imaging to Dual-Phase Helical CT Am. J. Roentgenol., July 1, 2002; 179(1): 67 - 73. [Abstract] [Full Text] [PDF]

				T. Tajima, H. Honda, K. Taguchi, Y. Asayama, T. Kuroiwa, K. Yoshimitsu, H. Irie, H. Aibe, M. Shimada, and K. Masuda Sequential Hemodynamic Change in Hepatocellular Carcinoma and Dysplastic Nodules: CT Angiography and Pathologic Correlation Am. J. Roentgenol., April 1, 2002; 178(4): 885 - 897. [Abstract] [Full Text] [PDF]

				H. Ding, M. Kudo, H. Onda, Y. Suetomi, Y. Minami, and K. Maekawa Hepatocellular Carcinoma: Depiction of Tumor Parenchymal Flow with Intermittent Harmonic Power Doppler US during the Early Arterial Phase in Dual-Display Mode Radiology, August 1, 2001; 220(2): 349 - 356. [Abstract] [Full Text] [PDF]

				H. Onaya, Y. Itai, M. Satake, T. Luo, Y. Saida, M. Haruno, T. Hasebe, and N. Moriyama Highly Enhanced Hepatic Masses Seen on CT During Arterial Portography: Early Hepatocellular Carcinoma and Adenomatous Hyperplasia Jpn. J. Clin. Oncol., October 1, 2000; 30(10): 440 - 445. [Abstract] [Full Text] [PDF]

				H.-J. Jang, J. H. Lim, S. J. Lee, C. K. Park, H. S. Park, and Y. S. Do Hepatocellular Carcinoma: Are Combined CT during Arterial Portography and CT Hepatic Arteriography in Addition to Triple-Phase Helical CT All Necessary for Preoperative Evaluation? Radiology, May 1, 2000; 215(2): 373 - 380. [Abstract] [Full Text]

				H. Kondo, M. Kanematsu, H. Hoshi, T. Murakami, T. Kim, M. Hori, M. Matsuo, and H. Nakamura Preoperative Detection of Malignant Hepatic Tumors: Comparison of Combined Methods of MR Imaging with Combined Methods of CT Am. J. Roentgenol., April 1, 2000; 174(4): 947 - 954. [Abstract] [Full Text] [PDF]

				J. H. Lim, E. Y. Kim, W. J. Lee, H. K. Lim, Y. S. Do, I.-W. Choo, and C. K. Park Regenerative Nodules in Liver Cirrhosis: Findings at CT during Arterial Portography and CT Hepatic Arteriography with Histopathologic Correlation Radiology, February 1, 1999; 210(2): 451 - 458. [Abstract] [Full Text]