Radiology, Vol 194, 113-118, Copyright © 1995 by Radiological Society of North America

ARTICLES

Hepatocellular carcinoma: use of color Doppler US to evaluate response to treatment with percutaneous ethanol injection

R Lencioni, D Caramella and C Bartolozzi
Department of Radiology, University of Pisa, Italy.

PURPOSE: To determine the usefulness of color Doppler ultrasound (US) in the evaluation of the response of hepatocellular carcinoma (HCC) to percutaneous ethanol injection (PEI). MATERIALS AND METHODS: Forty-one patients with 48 lesions 2-5 cm in diameter underwent color Doppler US before and after PEI. Computed tomography (CT), magnetic resonance (MR) imaging, and percutaneous biopsy were also performed to help establish the outcome of therapy. RESULTS: Before treatment, color signals with an arterial Doppler spectrum were seen in 44 of 48 lesions with a frequency shift of 0.51-4.11 kHz (mean, 1.65 kHz). After PEI, 37 of these lesions showed no color signal and were found to be necrotic at CT, MR imaging, and biopsy. In six of seven lesions containing residual tumor, pulsatile flow was still identified, although the frequency shift was significantly decreased (P = .01). CONCLUSION: Color Doppler US proved useful in the assessment of the therapeutic effect of PEI on HCC.

This article has been cited by other articles:

				F. Wu, Z.-B. Wang, W.-Z. Chen, H. Zhu, J. Bai, J.-Z. Zou, K.-Q. Li, C.-B. Jin, F.-L. Xie, and H.-B. Su Extracorporeal High Intensity Focused Ultrasound Ablation in the Treatment of Patients with Large Hepatocellular Carcinoma Ann. Surg. Oncol., December 1, 2004; 11(12): 1061 - 1069. [Abstract] [Full Text] [PDF]

				J. H. Youk, J. M. Lee, and C. S. Kim Therapeutic Response Evaluation of Malignant Hepatic Masses Treated by Interventional Procedures With Contrast-Enhanced Agent Detection Imaging J. Ultrasound Med., September 1, 2003; 22(9): 911 - 920. [Abstract] [Full Text] [PDF]

				Y. L. Wen, M. Kudo, R. Q. Zheng, Y. Minami, H. Chung, Y. Suetomi, H. Onda, M. Kitano, T. Kawasaki, and K. Maekawa Radiofrequency Ablation of Hepatocellular Carcinoma: Therapeutic Response Using Contrast-Enhanced Coded Phase-Inversion Harmonic Sonography Am. J. Roentgenol., July 1, 2003; 181(1): 57 - 63. [Abstract] [Full Text] [PDF]

				S. K. Kim, H. K. Lim, Y. H. Kim, W. J. Lee, S. J. Lee, S. H. Kim, J. H. Lim, and S. A. Kim Hepatocellular Carcinoma Treated with Radio-frequency Ablation: Spectrum of Imaging Findings RadioGraphics, January 1, 2003; 23(1): 107 - 121. [Abstract] [Full Text] [PDF]

				K. Shirato, M. Morimoto, N. Tomita, A. Kokawa, K. Sugimori, T. Saito, K. Numata, H. Sekihara, and K. Tanaka Hepatocellular Carcinoma: Therapeutic Experience With Percutaneous Ethanol Injection Under Real-time Contrast-Enhanced Color Doppler Sonography With the Contrast Agent Levovist J. Ultrasound Med., September 1, 2002; 21(9): 1015 - 1022. [Abstract] [Full Text] [PDF]

				D. Cioni, R. Lencioni, S. Rossi, F. Garbagnati, F. Donati, L. Crocetti, and C. Bartolozzi Radiofrequency Thermal Ablation of Hepatocellular Carcinoma: Using Contrast-Enhanced Harmonic Power Doppler Sonography to Assess Treatment Outcome Am. J. Roentgenol., October 1, 2001; 177(4): 783 - 788. [Abstract] [Full Text] [PDF]

				K. Numata, K. Tanaka, T. Kiba, S. Matsumoto, S. Iwase, K. Hara, H. Kirikoshi, K. Morita, S. Saito, and H. Sekihara Nonresectable Hepatocellular Carcinoma: Improved Percutaneous Ethanol Injection Therapy Guided by CO2-Enhanced Sonography Am. J. Roentgenol., October 1, 2001; 177(4): 789 - 798. [Abstract] [Full Text] [PDF]

				M.-d. Lu, J.-w. Chen, X.-y. Xie, L. Liu, X.-q. Huang, L.-j. Liang, and J.-f. Huang Hepatocellular Carcinoma: US-guided Percutaneous Microwave Coagulation Therapy Radiology, October 1, 2001; 221(1): 167 - 172. [Abstract] [Full Text] [PDF]

				H. Rhim, S. N. Goldberg, G. D. Dodd III, L. Solbiati, H. K. Lim, M. Tonolini, and O. K. Cho Essential Techniques for Successful Radio-frequency Thermal Ablation of Malignant Hepatic Tumors RadioGraphics, October 1, 2001; 21(90001): S17 - 35. [Abstract] [Full Text] [PDF]

				H. Ding, M. Kudo, H. Onda, Y. Suetomi, Y. Minami, and K. Maekawa Contrast-Enhanced Subtraction Harmonic Sonography for Evaluating Treatment Response in Patients with Hepatocellular Carcinoma Am. J. Roentgenol., March 1, 2001; 176(3): 661 - 666. [Abstract] [Full Text] [PDF]

				K. Takayasu, S. Arii, N. Matsuo, M. Yoshikawa, M. Ryu, K. Takasaki, M. Sato, N. Yamanaka, Y. Shimamura, and M. Ohto Comparison of CT Findings with Resected Specimens After Chemoembolization with Iodized Oil for Hepatocellular Carcinoma Am. J. Roentgenol., September 1, 2000; 175(3): 699 - 704. [Abstract] [Full Text] [PDF]

				K. Koito, T. Namieno, T. Ichimura, N. Hirokawa, T. Syonai, M. Hareyama, T. Katsuramaki, K. Hirata, and M. Nishi Power Doppler Sonography: Evaluation of Hepatocellular Carcinoma After Treatment with Transarterial Embolization or Percutaneous Ethanol Injection Therapy Am. J. Roentgenol., February 1, 2000; 174(2): 337 - 341. [Abstract] [Full Text] [PDF]

				H. Ding, M. Kudo, H. Onda, Y. Suetomi, Y. Minami, H. Chung, T. Kawasaki, and K. Maekawa Evaluation of Posttreatment Response of Hepatocellular Carcinoma with Contrast-enhanced Coded Phase-Inversion Harmonic US: Comparison with Dynamic CT Radiology, December 1, 2001; 221(3): 721 - 730. [Abstract] [Full Text] [PDF]