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Radiology, Vol 194, 687-691, Copyright © 1995 by Radiological Society of North America

ARTICLES

Brain mapping with functional MR imaging: comparison of gradient-echo-- based exogenous and endogenous contrast techniques

VS Mattay, DR Weinberger, FA Barrios, GS Sobering, KJ Kotrla, P van Gelderen, JH Duyn, RH Sexton, CT Moonen and JA Frank
Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892.

PURPOSE: To compare directly the two most widely used methods of functional magnetic resonance (MR) imaging--dynamic contrast material- enhanced MR imaging and blood oxygenation level-dependent (BOLD) MR imaging. MATERIALS AND METHODS: Five healthy volunteers underwent dynamic contrast-enhanced and BOLD MR imaging with a conventional 1.5-T MR unit during visual stimulation and a dark control state. BOLD studies were performed with a gradient-echo sequence, and dynamic MR imaging was performed with an echo-shifted gradient-echo sequence after intravenous administration of a bolus of gadopentetate dimeglumine. RESULTS: A significantly greater percentage signal change was found with dynamic MR imaging than with the BOLD technique. The extent of area activated was also significantly greater. CONCLUSION: With standard clinical imagers and these gradient-echo-based techniques, greater percentage activation and area of activation can be achieved with dynamic MR imaging than with BOLD MR imaging.


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