Radiology, Vol 195, 391-400, Copyright © 1995 by Radiological Society of North America

ARTICLES

Ovarian cancer: comparison of findings with perfluorocarbon-enhanced MR imaging, In-111-CYT-103 immunoscintigraphy, and CT

RN Low, WD Carter, F Saleh and JS Sigeti
Department of Diagnostic Radiology, Sharp Memorial Hospital, San Diego, CA 92123-2740, USA.

PURPOSE: To determine the accuracy of breath-hold gadolinium- and perflubron-enhanced magnetic resonance (MR) imaging, immunoscintigraphy with indium-111-CYT-103 (planar and single photon emission computed tomography [CT]), and contrast material-enhanced CT for the detection of ovarian cancer prior to laparotomy. MATERIALS AND METHODS: Sixteen patients with primary (n = 3) or treated (n = 13) ovarian cancer underwent imaging of the abdomen and pelvis with each modality. All images were reviewed prospectively for tumor location, and results were compared with findings at surgery. RESULTS: With CT or MR imaging, tumor was detected in 11 of 13 (85%) patients compared with 11 of 12 patients (92%) with immunoscintigraphy. Per patient accuracy for CT was 81% compared with 75% for MR imaging and 86% for immunoscintigraphy. For detection of individual sites of tumor, the sensitivity of MR imaging was highest (81%) compared with CT (51%, P < .001) and immunoscintigraphy (50%, P < .01). The combination of MR imaging and immunoscintigraphy depicted 89% of sites of tumor involvement confirmed at laparotomy. CONCLUSION: MR imaging and immunoscintigraphy show promise for the evaluation of patients with ovarian cancer.

This article has been cited by other articles:

				R. N. Low, R. M. Barone, J. M. Gurney, and W. D. Muller Mucinous Appendiceal Neoplasms: Preoperative MR Staging and Classification Compared with Surgical and Histopathologic Findings Am. J. Roentgenol., March 1, 2008; 190(3): 656 - 665. [Abstract] [Full Text] [PDF]

				R. N. Low, B. Duggan, R. M. Barone, F. Saleh, and S. Y. T. Song Treated Ovarian Cancer: MR Imaging, Laparotomy Reassessment, and Serum CA-125 Values Compared with Clinical Outcome at 1 Year Radiology, June 1, 2005; 235(3): 918 - 926. [Abstract] [Full Text] [PDF]

				P. J. Woodward, K. Hosseinzadeh, and J. S. Saenger From the Archives of the AFIP: Radiologic Staging of Ovarian Carcinoma with Pathologic Correlation RadioGraphics, January 1, 2004; 24(1): 225 - 246. [Abstract] [Full Text] [PDF]

				S.-M. Cho, H. K. Ha, J. Y. Byun, J. M. Lee, C. J. Kim, S. E. Nam-Koong, and J. M. Lee Usefulness of FDG PET for Assessment of Early Recurrent Epithelial Ovarian Cancer Am. J. Roentgenol., August 1, 2002; 179(2): 391 - 395. [Abstract] [Full Text] [PDF]

				F. V. Coakley, P. H. Choi, C. A. Gougoutas, B. Pothuri, E. Venkatraman, D. Chi, A. Bergman, and H. Hricak Peritoneal Metastases: Detection with Spiral CT in Patients with Ovarian Cancer Radiology, May 1, 2002; 223(2): 495 - 499. [Abstract] [Full Text] [PDF]

				R. C. Semelka and T. K. G. Helmberger Contrast Agents for MR Imaging of the Liver Radiology, January 1, 2001; 218(1): 27 - 38. [Abstract] [Full Text]

				Y.-Y. Jeong, E. K. Outwater, and H. K. Kang Imaging Evaluation of Ovarian Masses RadioGraphics, September 1, 2000; 20(5): 1445 - 1470. [Abstract] [Full Text] [PDF]

				S. Kawamoto, B. A. Urban, and E. K. Fishman CT of Epithelial Ovarian Tumors RadioGraphics, October 1, 1999; 19(90001): 85 - 102. [Abstract] [Full Text]

				R. N. Low, F. Saleh, S. Y. Thomas Song, T. A. Shiftan, R. M. Barone, C. G. Lacey, and P. M. Goldfarb Treated Ovarian Cancer: Comparison of MR Imaging with Serum CA-125 Level and Physical Examination—A Longitudinal Study Radiology, May 1, 1999; 211(2): 519 - 528. [Abstract] [Full Text]

				R. N. Low, R. C. Semelka, S. Worawattanakul, G. D. Alzate, and J. S. Sigeti Extrahepatic Abdominal Imaging in Patients with Malignancy: Comparison of MR Imaging and Helical CT, with Subsequent Surgical Correlation Radiology, March 1, 1999; 210(3): 625 - 632. [Abstract] [Full Text]