Radiology, Vol 196, 421-426, Copyright © 1995 by Radiological Society of North America

ARTICLES

Scintimammography: the complementary role of Tc-99m sestamibi prone breast imaging for the diagnosis of breast carcinoma

I Khalkhali, JA Cutrone, IG Mena, LE Diggles, RJ Venegas, HI Vargas, BL Jackson, S Khalkhali, JF Moss and SR Klein
Department of Radiology, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance 90502, USA.

PURPOSE: To evaluate the complementary role of technetium-99m sestamibi scintimammography in improvement of the sensitivity and specificity of mammography in detection of carcinoma of the breast. MATERIALS AND METHODS: At 5 and 60 minutes after intravenous injection of Tc-99m sestamibi, scintimammograms were obtained in 147 women (age range, 18- 73 years; mean age, 47.9 years +/- 10.2 [standard deviation]) with 153 lesions that warranted breast biopsy (102 lesions) or fine-needle aspiration cytologic analysis (51 lesions). There were 113 palpable and 40 nonpalpable lesions. Lesion size on mammograms was 0.8 x 0.6 cm to 15.0 x 11.0 cm (mean, 2.82 cm +/- 1.71 x 2.39 cm +/- 1.56). RESULTS: Scintimammographic findings were true-positive in 47 biopsy-confirmed carcinomas, true-negative in 91 benign lesions, false-positive in 11 lesions with benign histopathologic findings (fibrocystic disease [n = 8] or fibroadenoma [n = 3]), and false-negative in four lesions of infiltrating ductal carcinoma. The sensitivity of scintimammography was 92.2%; specificity, 89.2%; positive predictive value, 81.0%; and negative predictive value, 95.8%. CONCLUSION: The authors conclude that scintimammography is a sensitive test that can improve the detection of breast carcinoma.

This article has been cited by other articles:

				R. F. Brem, J. A. Rapelyea, G. Zisman, K. Mohtashemi, J. Raub, C. B. Teal, S. Majewski, and B. L. Welch Occult Breast Cancer: Scintimammography with High-Resolution Breast-specific Gamma Camera in Women at High Risk for Breast Cancer Radiology, October 1, 2005; 237(1): 274 - 280. [Abstract] [Full Text] [PDF]

				R. Tiling, K. Stephan, H. Sommer, N. Shabani, R. Linke, and K. Hahn Tissue-Specific Effects on Uptake of 99mTc-Sestamibi by Breast Lesions: A Targeted Analysis of False Scintigraphic Diagnoses J. Nucl. Med., November 1, 2004; 45(11): 1822 - 1828. [Abstract] [Full Text] [PDF]

				L. R. Coover, G. Caravaglia, and P. Kuhn Scintimammography with Dedicated Breast Camera Detects and Localizes Occult Carcinoma J. Nucl. Med., April 1, 2004; 45(4): 553 - 558. [Abstract] [Full Text] [PDF]

				P. B. Gordon, F. A. Gagnon, and L. Lanzkowsky Solid Breast Masses Diagnosed as Fibroadenoma at Fine-Needle Aspiration Biopsy: Acceptable Rates of Growth at Long-term Follow-up Radiology, October 1, 2003; 229(1): 233 - 238. [Abstract] [Full Text] [PDF]

				R. F. Brem, J. M. Schoonjans, D. A. Kieper, S. Majewski, S. Goodman, and C. Civelek High-Resolution Scintimammography: A Pilot Study J. Nucl. Med., July 1, 2002; 43(7): 909 - 915. [Abstract] [Full Text] [PDF]

				I. Khalkhali, J. K. Baum, J. Villanueva-Meyer, S. L. Edell, L. G. Hanelin, C. E. Lugo, R. Taillefer, L. M. Freeman, C. E. Neal, A. M. Scheff, et al. 99mTc Sestamibi Breast Imaging for the Examination of Patients with Dense and Fatty Breasts: Multicenter Study Radiology, January 1, 2002; 222(1): 149 - 155. [Abstract] [Full Text] [PDF]

				J. R. Buscombe, J. B. Cwikla, B. Holloway, and A. J.W. Hilson Prediction of the Usefulness of Combined Mammography and Scintimammography in Suspected Primary Breast Cancer Using ROC Curves J. Nucl. Med., January 1, 2001; 42(1): 3 - 8. [Abstract] [Full Text] [PDF]

				I. Khalkhali, J. Villanueva-Meyer, S. L. Edell, J. L. Connolly, S. J. Schnitt, J. K. Baum, M. J. Houlihan, R. M. Jenkins, and S. B. Haber Diagnostic Accuracy of 99mTc-Sestamibi Breast Imaging: Multicenter Trial Results J. Nucl. Med., December 1, 2000; 41(12): 1973 - 1979. [Abstract] [Full Text] [PDF]

				A. J. Klaus, W. C. Klingensmith III, S. H. Parker, A. T. Stavros, J. D. Sutherland, and K. D. Aldrete Comparative Value of 99mTc-Sestamibi Scintimammography and Sonography in the Diagnostic Workup of Breast Masses Am. J. Roentgenol., June 1, 2000; 174(6): 1779 - 1783. [Abstract] [Full Text]

				D. Cyrlak and P. M. Carpenter Cases of the Day : Breast Imaging Case of the Day RadioGraphics, October 1, 1999; 19(90001): 73 - 79. [Full Text]