Radiology, Vol 196, 689-695, Copyright © 1995 by Radiological Society of North America

ARTICLES

Dynamic contrast-enhanced subtraction MR angiography of the lower extremities: initial evaluation with a multisection two-dimensional time-of-flight sequence

MK Adamis, W Li, PA Wielopolski, D Kim, EJ Sax, KC Kent and RR Edelman
Department of Radiology, Beth Israel Hospital, Boston, MA 02215, USA.

PURPOSE: To determine the clinical feasibility of a contrast material-- enhanced two-dimensional (2D) magnetic resonance (MR) angiographic sequence in lower extremity arteries. MATERIALS AND METHODS: Four healthy volunteers and 12 patients underwent dynamic contrast-enhanced MR angiography; all patients also underwent conventional angiography. A 2D multisection gradient-echo sequence with image subtraction was used for all MR imaging examinations. RESULTS: Oblique-coronal contrast- enhanced MR angiography was completed in less than 4 minutes, with a 256 x 512 matrix. The arterial contrast enhancement ratio was 2.0 +/- 0.8 (standard deviation), and the pre- and post-contrast contrast-to- noise ratios were 2.1 +/- 13.8 and 46.2 +/- 18.7, respectively. The sensitivity for MR angiography was 100% and specificity was 69% for distinction of vessels with greater than 50% stenoses from normal or mildly stenotic vessels. CONCLUSION: Dynamic contrast-enhanced 2D MR angiography is capable of increasing intraarterial signal intensity and depicting small vessel anatomy of the lower extremities over a large field of view in a short imaging time.

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