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Radiology, Vol 196, 725-733, Copyright © 1995 by Radiological Society of North America

ARTICLES

Recurrent nasopharyngeal tumors: preliminary clinical results with interventional MR imaging--controlled laser-induced thermotherapy

TJ Vogl, MG Mack, P Muller, C Phillip, H Bottcher, A Roggan, M Juergens, M Deimling, D Knobber and P Wust
Department of Radiology, Humboldt-University of Berlin, Rudolf Virchow Clinic, Germany.

PURPOSE: To evaluate magnetic resonance (MR) imaging-controlled laser- induced thermotherapy (LITT) in the treatment of recurrent head and neck tumors. MATERIALS AND METHODS: Six patients with recurrent nasopharyngeal tumors (squamous cell carcinoma [n = 4], pleomorphic adenoma [n = 2]) underwent LITT with local anesthesia. A 7-F introducing sheath was inserted into the center of the tumor followed by a specially designed laser emitter. Therapy was monitored on-line with MR thermometry, and the amount of necrosis was estimated with dynamic and static contrast material-enhanced sequences. RESULTS: All procedures were well tolerated with use of local anesthesia, with no clinically relevant side effects. MR thermometry depicted up to 15-mm- diameter areas of less signal intensity near the laser tip. Coagulative necrosis was achieved in all patients (volume range, 4-28 cm3), and clinical symptoms were reduced in four. CONCLUSION: MR imaging- controlled LITT may be a safe, minimally invasive alternative in the treatment of recurrent head and neck tumors.


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