Radiology, Vol 197, 205-211, Copyright © 1995 by Radiological Society of North America

ARTICLES

Head and neck cancer: detection of recurrence with PET and 2-[F- 18]fluoro-2-deoxy-D-glucose

M Lapela, R Grenman, T Kurki, H Joensuu, S Leskinen, P Lindholm, M Haaparanta, U Ruotsalainen and H Minn
Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland.

PURPOSE: To evaluate positron emission tomography (PET) with 2- [fluorine-18]fluoro-2-deoxy-D-glucose (FDG) in detection of suspected recurrence of head and neck cancer, and to compare visual, static, and kinetic analyses of the tracer uptake. MATERIALS AND METHODS: Seventeen dynamic FDG PET studies were performed in 15 patients. The images were interpreted visually, and the uptake was quantitated as the standardized uptake value (SUV) and as the regional FDG metabolic rate. RESULTS: Sensitivity of blinded visual interpretation of the PET images for the presence of malignancy was 88% and specificity was 86%. Malignant lesions accumulated significantly more FDG than benign lesions (P = .008 for SUVs, P = .002 for regional metabolic rates). When maximum uptake of FDG in the benign lesions was used as a threshold, the sensitivity of SUV analysis for malignancy was 75% and that of regional metabolic rates was 86%. CONCLUSION: Detection of recurrent head and neck cancer is feasible with FDG PET. Quantitation of FDG uptake assists in correct interpretation of the PET images.

This article has been cited by other articles:

				S. Y. Kim, S.-w. Lee, S. Y. Nam, K. C. Im, J.-S. Kim, S. J. Oh, S. D. Ahn, S. S. Shin, E. K. Choi, and J. H. Kim The Feasibility of 18F-FDG PET Scans 1 Month After Completing Radiotherapy of Squamous Cell Carcinoma of the Head and Neck J. Nucl. Med., March 1, 2007; 48(3): 373 - 378. [Abstract] [Full Text] [PDF]

				T. M. Blodgett, C. C. Meltzer, and D. W. Townsend PET/CT: Form and Function Radiology, February 1, 2007; 242(2): 360 - 385. [Abstract] [Full Text] [PDF]

				M. B. Fukui, T. M. Blodgett, C. H. Snyderman, J. J. Johnson, E. N. Myers, D. W. Townsend, and C. C. Meltzer Combined PET-CT in the Head and Neck: Part 2. Diagnostic Uses and Pitfalls of Oncologic Imaging RadioGraphics, July 1, 2005; 25(4): 913 - 930. [Abstract] [Full Text] [PDF]

				F. Dammann, M. Horger, M. Mueller-Berg, H. Schlemmer, C. Claussen, J. Hoffman, S. Eschmann, and R. Bares Rational Diagnosis of Squamous Cell Carcinoma of the Head and Neck Region: Comparative Evaluation of CT, MRI, and 18FDG PET Am. J. Roentgenol., April 1, 2005; 184(4): 1326 - 1331. [Abstract] [Full Text] [PDF]

				N. Shu-Hang, J. C. Tung-Chieh, C. Sheng-Chieh, K. Sheung-Fat, W. Hung-Ming, L. Chun-Ta, C. Yu-Chen, W.-J. Lin, F. Ying-Kai, and Y. Tzu-Chen Clinical Usefulness of 18F-FDG PET in Nasopharyngeal Carcinoma Patients with Questionable MRI Findings for Recurrence J. Nucl. Med., October 1, 2004; 45(10): 1669 - 1676. [Abstract] [Full Text] [PDF]

				S. K. Mukherji, I. M. Schmalfuss, J. Castelijns, and A. A. Mancuso Clinical Applications of Tumor Volume Measurements for Predicting Outcome in Patients with Squamous Cell Carcinoma of the Upper Aerodigestive Tract AJNR Am. J. Neuroradiol., September 1, 2004; 25(8): 1425 - 1432. [Abstract] [Full Text] [PDF]

				S-H Liu, J T Chang, S-H Ng, S-C Chan, and T-C Yen False positive fluorine-18 fluorodeoxy-D-glucose positron emission tomography finding caused by osteoradionecrosis in a nasopharyngeal carcinoma patient Br. J. Radiol., March 1, 2004; 77(915): 257 - 260. [Abstract] [Full Text] [PDF]

				S. K. Mukherji and G. T. Wolf Evaluation of Head and Neck Squamous Cell Carcinoma After Treatment AJNR Am. J. Neuroradiol., October 1, 2003; 24(9): 1743 - 1746. [Full Text] [PDF]

				S. S. Gambhir, J. Czernin, J. Schwimmer, D. H. S. Silverman, R. E. Coleman, and M. E. Phelps A Tabulated Summary of the FDG PET Literature J. Nucl. Med., May 1, 2001; 42(90050): 1S - 93. [Full Text] [PDF]

				R. Hermans, F. A. Pameijer, A. A. Mancuso, J. T. Parsons, and W. M. Mendenhall Laryngeal or Hypopharyngeal Squamous Cell Carcinoma: Can Follow-up CT after Definitive Radiation Therapy Be Used to Detect Local Failure Earlier than Clinical Examination Alone? Radiology, March 1, 2000; 214(3): 683 - 687. [Abstract] [Full Text]

				V. J. Lowe, J. H. Boyd, F. R. Dunphy, H. Kim, T. Dunleavy, B. T. Collins, D. Martin, B. C. Stack Jr, C. Hollenbeak, and J. W. Fletcher Surveillance for Recurrent Head and Neck Cancer Using Positron Emission Tomography J. Clin. Oncol., February 1, 2000; 18(3): 651 - 651. [Abstract] [Full Text] [PDF]

				S. K. Mukherji, M. Gapany, D. Phillips, B. Neelon, S. O' O'Brien, W. McCartney, S. Buejenovich, J. S. Parekh, J. P. Noordzij, and M. Castillo Thallium-201 Single-Photon Emission CT versus CT for the Detection of Recurrent Squamous Cell Carcinoma of the Head and Neck AJNR Am. J. Neuroradiol., August 1, 1999; 20(7): 1215 - 1220. [Abstract] [Full Text]

				Y. Anzai, S. Minoshima, G. T. Wolf, and R. L. Wahl Head and Neck Cancer: Detection of Recurrence with Three-dimensional Principal Components Analysis at Dynamic FDG PET Radiology, July 1, 1999; 212(1): 285 - 290. [Abstract] [Full Text]

				V. P. Mathews, K. S. Caldemeyer, M. J. Lowe, S. L. Greenspan, D. M. Weber, and J. L. Ulmer Brain: Gadolinium-enhanced Fast Fluid-attenuated Inversion-Recovery MR Imaging Radiology, April 1, 1999; 211(1): 257 - 263. [Abstract] [Full Text]

				L. G. Strauss Positron Emission Tomography: Current Role for Diagnosis and Therapy Monitoring in Oncology Oncologist, December 1, 1997; 2(6): 381 - 388. [Abstract] [Full Text] [PDF]