Radiology, Vol 197, 59-65, Copyright © 1995 by Radiological Society of North America

ARTICLES

Unusual lymphoproliferative disorders in nine adults with HIV or AIDS: CT and pathologic findings

G McGuinness, JV Scholes, JS Jagirdar, E Lubat, BS Leitman, M Bhalla, DI McCauley, SM Garay and DP Naidich
Department of Radiology, New York University Medical Center, NY 10016, USA.

PURPOSE: To identify characteristic computed tomographic (CT) findings in unusual pulmonary lymphoproliferative disorders seen in adults with the human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). MATERIALS AND METHODS: The authors retrospectively reviewed the CT scans and pathologic specimens from nine patients with pulmonary lymphoproliferative disorders. CT scans were evaluated for nodules, reticulation, areas of ground-glass attenuation, consolidation, and bronchial disease. Changes seen in pathologic specimens were classified as consistent with classic lymphocytic interstitial pneumonitis (LIP), mucosa-associated lymphoid tissue lymphoma (MALTOMA), or atypical lymphoproliferative disorder (ALD). Immunopathologic results were reviewed when available. RESULTS: Eight patients had AIDS. Five patients had classic LIP. One patient had MALTOMA, and three patients had ALD. Altogether, 2-4-mm-diameter nodules were the predominant CT finding in eight patients; these were peribronchovascular in four patients. The presence of interstitial nodules correlated with the pathologic finding of nodular disease in seven patients. CONCLUSION: Familiarity with these AIDS-related disorders and their CT appearance should assist in the differential diagnosis.

This article has been cited by other articles:

				H. Thomas, K. A. Risma, T. B. Graham, A. S. Brody, G. H. Deutsch, L. R. Young, and P. M. Joseph A Kindred of Children With Interstitial Lung Disease Chest, July 1, 2007; 132(1): 221 - 230. [Abstract] [Full Text] [PDF]

				W. R. Webb Thin-Section CT of the Secondary Pulmonary Lobule: Anatomy and the Image--The 2004 Fleischner Lecture Radiology, May 1, 2006; 239(2): 322 - 338. [Abstract] [Full Text] [PDF]

				W. T. Miller Jr. and R. M. Shah Isolated Diffuse Ground-Glass Opacity in Thoracic CT: Causes and Clinical Presentations Am. J. Roentgenol., February 1, 2005; 184(2): 613 - 622. [Full Text] [PDF]

				R. V. Alva, L. Rosenthal, L. B. Haramati, R. Madan, and T. K. Aldrich Lymphoepithelial Cyst in the Lung: A Case Report Chest, April 1, 2003; 123(4): 1299 - 1302. [Abstract] [Full Text] [PDF]

				J. J. Swigris, G. J. Berry, T. A. Raffin, and W. G. Kuschner Lymphoid Interstitial Pneumonia: A Narrative Review Chest, December 1, 2002; 122(6): 2150 - 2164. [Abstract] [Full Text] [PDF]

				L J King and S P G Padley Imaging of the thorax in AIDS Imaging, February 1, 2002; 14(1): 60 - 76. [Abstract] [Full Text] [PDF]

				S. J. Howling, D. M. Hansell, A. U. Wells, A. G. Nicholson, J. D. A. Flint, and N. L. Müller Follicular Bronchiolitis: Thin-Section CT and Histologic Findings Radiology, September 1, 1999; 212(3): 637 - 642. [Abstract] [Full Text]

				T. Johkoh, N. L. Müller, H. A. Pickford, T. E. Hartman, K. Ichikado, M. Akira, O. Honda, and H. Nakamura Lymphocytic Interstitial Pneumonia: Thin-Section CT Findings in 22 Patients Radiology, August 1, 1999; 212(2): 567 - 572. [Abstract] [Full Text]