Radiology, Vol 197, 525-531, Copyright © 1995 by Radiological Society of North America

ARTICLES

Brain lesions in patients with AIDS: H-1 MR spectroscopy [published erratum appears in Radiology 1996 Feb;198(2):586]

L Chang, BL Miller, D McBride, M Cornford, G Oropilla, S Buchthal, F Chiang, H Aronow, CK Beck and T Ernst
Department of Neurology, Harbor-University of California Los Angeles Medical Center, University of California Los Angeles School of Medicine, Torrance 90509, USA.

PURPOSE: To evaluate the role of proton (hydrogen-1) magnetic resonance (MR) spectroscopy in the differential diagnosis of focal brain lesions in patients with acquired immunodeficiency syndrome (AIDS). MATERIALS AND METHODS: Twenty-six men with 35 AIDS-related brain lesions underwent MR imaging and localized H-1 MR spectroscopy. Lesions consisted of 11 toxoplasmic abscesses, 12 progressive multifocal leukoencephalopathic lesions, eight lymphomas, and four cryptococcomas. Metabolite peak areas in the lesions were compared with those in the contralateral hemisphere in each patient. RESULTS: H-1 MR spectroscopic findings showed significantly different biochemical profiles for each diagnostic group (P = .0001) with regard to N-acetyl compounds, total creatine pool, choline-containing compounds, myoinositol, and lactate. H-1 MR spectroscopy alone helped correctly diagnose 94% (84% with jackknifed classification) of the brain lesions, without overlap between toxoplasmosis and lymphoma. CONCLUSION: H-1 MR spectroscopy is a sensitive and potentially specific noninvasive adjunctive method for differential diagnosis of focal brain lesions in AIDS.

This article has been cited by other articles:

				R. N. Al-Okaili, J. Krejza, S. Wang, J. H. Woo, and E. R. Melhem Advanced MR Imaging Techniques in the Diagnosis of Intraaxial Brain Tumors in Adults RadioGraphics, October 1, 2006; 26(suppl_1): S173 - S189. [Abstract] [Full Text] [PDF]

				L. Gabis, A. Belman, Wei Huang, M. Milazzo, and S. Nachman Clinical and Imaging Study of Human Immunodeficiency Virus-1--Infected Youth Receiving Highly Active Antiretroviral Therapy: Pilot Study Using Magnetic Resonance Spectroscopy J Child Neurol, June 1, 2006; 21(6): 485 - 490. [Abstract] [PDF]

				T. E. Nordahl, R. Salo, Y. Natsuaki, G. P. Galloway, C. Waters, C. D. Moore, S. Kile, and M. H. Buonocore Methamphetamine Users in Sustained Abstinence: A Proton Magnetic Resonance Spectroscopy Study Arch Gen Psychiatry, April 1, 2005; 62(4): 444 - 452. [Abstract] [Full Text] [PDF]

				P. H. Lai, K. T. Li, S. S. Hsu, C. C. Hsiao, C. W. Yip, S. Ding, L. R. Yeh, and H. B. Pan Pyogenic Brain Abscess: Findings from In Vivo 1.5-T and 11.7-T In Vitro Proton MR Spectroscopy AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 279 - 288. [Abstract] [Full Text] [PDF]

				R. Katz-Brull, R. E. Lenkinski, R. A. Du Pasquier, and I. J. Koralnik Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy Neurology, September 14, 2004; 63(5): 897 - 900. [Abstract] [Full Text] [PDF]

				C. Ionita, M. Wasay, L. Balos, and R. Bakshi MR Imaging in Toxoplasmosis Encephalitis after Bone Marrow Transplantation: Paucity of Enhancement despite Fulminant Disease AJNR Am. J. Neuroradiol., February 1, 2004; 25(2): 270 - 273. [Abstract] [Full Text] [PDF]

				D. L. A. Camacho, J. K. Smith, and M. Castillo Differentiation of Toxoplasmosis and Lymphoma in AIDS Patients by Using Apparent Diffusion Coefficients AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 633 - 637. [Abstract] [Full Text] [PDF]

				R. A. Hurley, T. Ernst, K. Khalili, L. Del Valle, I. L. Simone, and K. H. Taber Identification of HIV-Associated Progressive Multifocal Leukoencephalopathy: Magnetic Resonance Imaging and Spectroscopy J Neuropsychiatry Clin Neurosci, February 1, 2003; 15(1): 1 - 6. [Full Text] [PDF]

				N A Sibtain and R J S Chinn Imaging of the central nervous system in HIV infection Imaging, February 1, 2002; 14(1): 48 - 59. [Abstract] [Full Text] [PDF]

				B. C. Bowen, P. M. Pattany, W. G. Bradley, J. B. Murdoch, F. Rotta, A. A. Younis, R. C. Duncan, and R. M. Quencer MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis AJNR Am. J. Neuroradiol., April 1, 2000; 21(4): 647 - 658. [Abstract] [Full Text]

				P. E. Ricci, A. Pitt, P. J. Keller, S. W. Coons, and J. E. Heiserman Effect of Voxel Position on Single-Voxel MR Spectroscopy Findings AJNR Am. J. Neuroradiol., February 1, 2000; 21(2): 367 - 374. [Abstract] [Full Text]

				S. Grand, G. Passaro, A. Ziegler, F. Estève, C. Boujet, D. Hoffmann, C. Rubin, C. Segebarth, M. Décorps, J.-F. Le Bas, et al. Necrotic Tumor versus Brain Abscess: Importance of Amino Acids Detected at 1H MR Spectroscopy-Initial Results Radiology, December 1, 1999; 213(3): 785 - 793. [Abstract] [Full Text]

				A. Iranzo, A. Moreno, J. Pujol, J. Martí-Fàbregas, P. Domingo, J. Molet, J. Ris, and J. Cadafalch Proton magnetic resonance spectroscopy pattern of progressive multifocal leukoencephalopathy in AIDS J. Neurol. Neurosurg. Psychiatry, April 1, 1999; 66(4): 520 - 523. [Abstract] [Full Text]

				T. Ernst, L. Chang, M. Witt, I. Walot, H. Aronow, M. Leonido-Yee, and E. Singer Progressive Multifocal Leukoencephalopathy and Human Immunodeficiency Virus–associated White Matter Lesions in AIDS: Magnetization Transfer MR Imaging Radiology, February 1, 1999; 210(2): 539 - 543. [Abstract] [Full Text]

				I L Simone, F Federico, C Tortorella, C F Andreula, G B Zimatore, P Giannini, G Angarano, V Lucivero, P Picciola, D Carrara, et al. Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV J. Neurol. Neurosurg. Psychiatry, April 1, 1998; 64(4): 516 - 523. [Abstract] [Full Text] [PDF]

				B. Movsas, B. S. Y. Li, J. S. Babb, B. L. Fowble, N. Nicolaou, and O. Gonen Quantifying Radiation Therapy-induced Brain Injury with Whole-Brain Proton MR Spectroscopy: Initial Observations Radiology, November 1, 2001; 221(2): 327 - 331. [Abstract] [Full Text] [PDF]