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Radiology, Vol 197, 859-862, Copyright © 1995 by Radiological Society of North America

ARTICLES

Limited-stage small-cell lung cancer: patient survival after combined chemotherapy and radiation therapy with and without treatment protocols

RA Schea, P Perkins, PK Allen, R Komaki and JD Cox
Department of Radiotherapy, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.

PURPOSE: To compare survival of patients who undergo treatment in protocols versus survival of patients not in protocols. MATERIALS AND METHODS: Records of 81 adult patients with small-cell lung cancer who underwent chemotherapy and radiation therapy in 1987-1992 were reviewed retrospectively. Forty-one patients were in a protocol; 40 patients were not. Patient demographics and prognostic factors were not statistically significantly different. RESULTS: Median overall survival was 16.7 months in the nonprotocol group versus 29.0 months in the protocol group (P = .0023). Median disease-specific survival was 18.3 months in the nonprotocol group versus 27.1 months in the protocol group (P = .0176). Survival was not statistically significantly influenced by Karnofsky performance status, weight loss, or thoracic radiation dose. CONCLUSION: There was a highly statistically significant difference in survival outcome in the nonprotocol group versus the protocol group (P = .0023). Differences in chemotherapy- radiation therapy timing and other treatment-related factors may have contributed substantially to the improved survival in the protocol group.




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Copyright © 1995 by the Radiological Society of North America.