Radiology, Vol 199, 787-791, Copyright © 1996 by Radiological Society of North America

ARTICLES

Hippocampal MR imaging morphometry by means of general pattern matching

JW Haller, GE Christensen, SC Joshi, JW Newcomer, MI Miller, JG Csernansky and MW Vannier
Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 63110, USA.

PURPOSE: To determine the repeatability and validity of a pattern- matching method for the segmentation and measurement of hippocampi on magnetic resonance (MR) images. MATERIALS AND METHODS: Comparable two- dimensional MR images obtained in 18 subjects (nine healthy control subjects [six men, three women; aged 24-54 years] and nine patients with schizophrenia [six men, three women; aged 22-61 years]) were twice segmented manually and twice segmented by using pattern matching with digital atlas transformation. The atlas transformation was accomplished in two steps: global followed by local matching. Global matching was performed with use of landmarks; local matching was performed with use of a viscous fluid model. RESULTS: The mean percentage of difference between two atlas-based measurements was 1.33% +/- 1.23 (+/- standard deviation); that between two manual measurements was 4.67% +/- 4.71. The validity of the atlas transformation measurements was demonstrated by means of the high correlation (intraclass correlation coefficient = .96) with manual segmentation measurements. Schizophrenic hippocampal areas tended to be smaller; however, no differences in hippocampal shape were found between patients with schizophrenia and patients with control subjects. CONCLUSION: General pattern matching of a digital brain atlas to an individual MR image is a mathematically robust method of measurement that is reproducible and less variable than manual measurement.

This article has been cited by other articles:

				R I SCAHILL and N C FOX Longitudinal imaging in dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S92 - S98. [Abstract] [Full Text] [PDF]

				B. H. Ridha, J. Barnes, L. A. van de Pol, J. M. Schott, R. G. Boyes, M. M. Siddique, M. N. Rossor, P. Scheltens, and N. C. Fox Application of Automated Medial Temporal Lobe Atrophy Scale to Alzheimer Disease Arch Neurol, June 1, 2007; 64(6): 849 - 854. [Abstract] [Full Text] [PDF]

				D. Mungas, D. Harvey, B. R. Reed, W. J. Jagust, C. DeCarli, L. Beckett, W. J. Mack, J. H. Kramer, M. W. Weiner, N. Schuff, et al. Longitudinal volumetric MRI change and rate of cognitive decline Neurology, August 23, 2005; 65(4): 565 - 571. [Abstract] [Full Text] [PDF]

				C. DeCarli, D. Mungas, D. Harvey, B. Reed, M. Weiner, H. Chui, and W. Jagust Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia Neurology, July 27, 2004; 63(2): 220 - 227. [Abstract] [Full Text] [PDF]

				C. D Good Dementia and ageing: Imaging in clinical neuroscience Br. Med. Bull., March 1, 2003; 65(1): 159 - 168. [Abstract] [Full Text] [PDF]

				J. A. Posener, L. Wang, J. L. Price, M. H. Gado, M. A. Province, M. I. Miller, C. M. Babb, and J. G. Csernansky High-Dimensional Mapping of the Hippocampus in Depression Am J Psychiatry, January 1, 2003; 160(1): 83 - 89. [Abstract] [Full Text] [PDF]

				D. Mungas, B. R. Reed, W. J. Jagust, C. DeCarli, W. J. Mack, J. H. Kramer, M. W. Weiner, N. Schuff, and H. C. Chui Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease Neurology, September 24, 2002; 59(6): 867 - 873. [Abstract] [Full Text] [PDF]

				D. Mungas, W. J. Jagust, B. R. Reed, J. H. Kramer, M. W. Weiner, N. Schuff, D. Norman, W. J. Mack, L. Willis, and H. C. Chui MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease Neurology, December 26, 2001; 57(12): 2229 - 2235. [Abstract] [Full Text] [PDF]

				V. Megalooikonomou, J. Ford, L. Shen, F. Makedon, and A. Saykin Data mining in brain imaging Statistical Methods in Medical Research, August 1, 2000; 9(4): 359 - 394. [Abstract] [PDF]

				R. E. Hogan, K. E. Mark, L. Wang, S. Joshi, M. I. Miller, and R. D. Bucholz Mesial Temporal Sclerosis and Temporal Lobe Epilepsy: MR Imaging Deformation-based Segmentation of the Hippocampus in Five Patients Radiology, July 1, 2000; 216(1): 291 - 297. [Abstract] [Full Text]

				J. G. Csernansky, S. Joshi, L. Wang, J. W. Haller, M. Gado, J. P. Miller, U. Grenander, and M. I. Miller Hippocampal morphometry in schizophrenia by high dimensional brain mapping PNAS, September 15, 1998; 95(19): 11406 - 11411. [Abstract] [Full Text] [PDF]

				A. Wolkin, H. Rusinek, G. Vaid, L. Arena, T. Lafargue, M. Sanfilipo, C. Loneragan, A. Lautin, and J. Rotrosen Structural Magnetic Resonance Image Averaging in Schizophrenia Am J Psychiatry, August 1, 1998; 155(8): 1064 - 1073. [Abstract] [Full Text]

				M. Miller, A. Banerjee, G. Christensen, S. Joshi, N. Khaneja, U. Grenander, and L. Matejic Statistical methods in computational anatomy Statistical Methods in Medical Research, June 1, 1997; 6(3): 267 - 299. [Abstract] [PDF]