Radiology, Vol 200, 177-184, Copyright © 1996 by Radiological Society of North America

ARTICLES

Quantitative cardiac perfusion: a noninvasive spin-labeling method that exploits coronary vessel geometry

SB Reeder, MK Atalay, ER McVeigh, EA Zerhouni and JR Forder
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

PURPOSE: To quantitate myocardial arterial perfusion with a noninvasive magnetic resonance (MR) imaging technique that exploits the geometry of coronary vessel anatomy. MATERIALS AND METHODS: MR imaging was performed with a spin-labeling method in six arrested rabbit hearts at 4.7 T. Selective inversion of magnetization in the short-axis imaging section along with all myocardium apical to that section produces signal enhancement from arterial perfusion. A linescan protocol was used for validation of flow enhancement. Flow was quantitated from two images and validated with spin-echo (SE) imaging. Regional perfusion defects were created by means of coronary artery ligation and delineated with gadolinium-enhanced imaging. RESULTS: Linescan estimates of T1 obtained at physiologic flows agreed with model predictions. Flow-induced signal enhancement measured on SE images also agreed with expected values. Finally, perfusion abnormalities created by means of coronary artery ligation were detected. CONCLUSION: This spin-labeling method provides quantitative estimates of myocardial arterial perfusion in this model and may hold promise for clinical applications.

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