| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Radiology, Vol 200, 69-77, Copyright © 1996 by Radiological Society of North America
ARTICLES |
T Murakami, RL Baron, MS Peterson, JH Oliver 3rd, PL Davis, SR Confer and MP Federle
Department of Radiology, University of Pittsburgh Medical Center, PA 15213-2582, USA.
PURPOSE: To determine the efficacy of manganese (II) N,N'- dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP) at magnetic resonance (MR) imaging for evaluation of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: MR imaging at 1.5 T was performed in 20 patients with 65 HCC nodules. T1- and T2-weighted spin- echo and T1-weighted gradient-recalled-echo images were obtained before and after administration of 5 mumol/kg Mn-DPDP. Readers individually evaluated the pre- and postcontrast images for detection of tumor nodules, with subsequent consensus reading for interpretation discrepancies. Quantitative measurements of tumor-liver contrast-to- noise ratio (C/N) were also performed. Enhancement characteristics were correlated with histologic tumor differentiation. RESULTS: Precontrast images depicted 50 lesions in 17 patients, and postcontrast images depicted 49 lesions in 20 patients. Combination of pre- and postcontrast images enabled detection of 53 lesions in 20 patients. Three lesions (three patients) were seen only on postcontrast images. Four lesions (three patients) were seen only on precontrast images. Reader evaluation of tumor conspicuity showed a significant preference for precontrast T2-weighted SE images (P < .01). Quantitative evaluation showed a significant increase in C/N on postcontrast T1- weighted images (P < .01). Well-differentiated lesions showed significantly greater enhancement than that of poorly differentiated lesions (P < .05). CONCLUSION: Mn-DPDP-enhanced MR imaging depicts HCC tumors not visualized with unenhanced studies. The degree of tumor enhancement correlates with histologic differentiation.
This article has been cited by other articles:
|
|
 |
|
  J. H. Youk, J. M. Lee, and C. S. Kim MRI for Detection of Hepatocellular Carcinoma: Comparison of Mangafodipir Trisodium and Gadopentetate Dimeglumine Contrast Agents Am. J. Roentgenol., October 1, 2004; 183(4): 1049 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Bryant, M. J. Blomley, T. Albrecht, P. S. Sidhu, E. L. S. Leen, R. Basilico, J. M. Pilcher, L. H. Bushby, C. W. Hoffmann, C. J. Harvey, et al. Improved Characterization of Liver Lesions with Liver-Phase Uptake of Liver-specific Microbubbles: Prospective Multicenter Study Radiology, September 1, 2004; 232(3): 799 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Zuo, P. R. Seoane, J. Hu, P. P. Harnish, and N. M. Rofsky MR Imaging of the Stomach: Potential Use for Mangafodipir Trisodium-- A Study in Swine Radiology, July 1, 2004; 232(1): 160 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Szklaruk, P. M. Silverman, and C. Charnsangavej Imaging in the Diagnosis, Staging, Treatment, and Surveillance of Hepatocellular Carcinoma Am. J. Roentgenol., February 1, 2003; 180(2): 441 - 454. [Full Text] [PDF]
|
|
|
|
|
|
S. K. Kim, S. H. Kim, W. J. Lee, H. Kim, J. W. Seo, D. Choi, H. K. Lim, S. J. Lee, and J. H. Lim Preoperative Detection of Hepatocellular Carcinoma: Ferumoxides-Enhanced Versus Mangafodipir Trisodium--Enhanced MR Imaging Am. J. Roentgenol., September 1, 2002; 179(3): 741 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oudkerk, C. G. Torres, B. Song, M. Konig, J. Grimm, J. Fernandez-Cuadrado, B. Op de Beeck, M. Marquardt, P. van Dijk, and J. C. de Groot Characterization of Liver Lesions with Mangafodipir Trisodium-enhanced MR Imaging: Multicenter Study Comparing MR and Dual-Phase Spiral CT Radiology, May 1, 2002; 223(2): 517 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. N. Mann, H. F. Marx, L. L. Lai, and L. D. Wagman Clinical and Cost Effectiveness of a New Hepatocellular MRI Contrast Agent, Mangafodipir Trisodium, in the Preoperative Assessment of Liver Resectability Ann. Surg. Oncol., August 1, 2001; 8(7): 573 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Sica, H. Ji, and P. R. Ros CT and MR Imaging of Hepatic Metastases Am. J. Roentgenol., March 1, 2000; 174(3): 691 - 698. [Full Text] [PDF]
|
|
|
|
|
|
T. Ichikawa, M. P. Federle, L. Grazioli, J. Madariaga, M. Nalesnik, and W. Marsh Fibrolamellar Hepatocellular Carcinoma: Imaging and Pathologic Findings in 31 Recent Cases Radiology, November 1, 1999; 213(2): 352 - 361. [Abstract] [Full Text]
|
|
|
|
|
|
F. Forsberg, B. B. Goldberg, J.-B. Liu, D. A. Merton, N. M. Rawool, and W. T. Shi Tissue-Specific US Contrast Agent for Evaluation of Hepatic and Splenic Parenchyma Radiology, January 1, 1999; 210(1): 125 - 132. [Abstract] [Full Text]
|
|
|
|
|
|
L. Grazioli, G. Morana, M. P. Federle, G. Brancatelli, M. Testoni, M. A. Kirchin, K. Menni, L. Olivetti, N. Nicoli, and C. Procacci Focal Nodular Hyperplasia: Morphologic and Functional Information from MR Imaging with Gadobenate Dimeglumine Radiology, December 1, 2001; 221(3): 731 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Forsberg, C. W. Piccoli, J.-B. Liu, N. M. Rawool, D. A. Merton, D. G. Mitchell, and B. B. Goldberg Hepatic Tumor Detection: MR Imaging and Conventional US versus Pulse-Inversion Harmonic US of NC100100 during Its Reticuloendothelial System-Specific Phase Radiology, March 1, 2002; 222(3): 824 - 829. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
