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Radiology, Vol 200, 537-540, Copyright © 1996 by Radiological Society of North America

ARTICLES

First-trimester nuchal translucency: a risk analysis on fetal chromosome abnormality

JM van Vugt, RM van Zalen-Sprock and PJ Kostense
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.

PURPOSE: To investigate the importance of nuchal translucencies in the first trimester of pregnancy as an ultrasonographic marker for fetal chromosome abnormalities. MATERIALS AND METHODS: One hundred two first- trimester fetuses with a nuchal translucency of 3 mm or more were karyotyped. Multiple logistic regression analysis was performed to estimate the risk of fetal chromosomal abnormalities related to nuchal translucencies. RESULTS: Fifty-five (54%) of the fetuses had a normal karyotype. Forty-seven (46%) had an abnormal karyotype. The risk of chromosome abnormality was strongly increased in fetuses with a septated nuchal translucency compared with fetuses with a nonseptated nuchal translucency. CONCLUSION: First-trimester nuchal translucency is an important ultrasonographic marker for chromosomal abnormalities in the fetus. The presence of a normal karyotype in a fetus is a strong indication that detailed ultrasonographic examination for associated anomalies should be undertaken.


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M. C. Haak, M. M. Bartelings, D. G. Jackson, S. Webb, J. M.G.v. Vugt, and A. C.G.-d. Groot
Increased nuchal translucency is associated with jugular lymphatic distension
Hum. Reprod., April 1, 2002; 17(4): 1086 - 1092.
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