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Radiology, Vol 200, 615-619, Copyright © 1996 by Radiological Society of North America


ARTICLES

Effect of delayed radiation therapy on local control in breast conservation therapy

AG Meek, TL Park, TA Weiss and WA Bethune
Department of Radiation Oncology, University Hospital, Stony Brook, NY 11794-7028, USA.

PURPOSE: To assess local control when radiation therapy is delayed to complete chemotherapy in breast conservation therapy. MATERIALS AND METHODS: Breast conservation therapy was performed in 310 cases in 297 patients (aged 24-85 years) with stage 0-II breast cancer. Adjuvant chemotherapy was used in 76 cases. The authors analyzed the time between diagnosis and radiation therapy and correlated these findings with local control of disease. RESULTS: The time between diagnosis and radiation therapy in the 247 cases treated without chemotherapy-related delay was 2-59 weeks (mean, 8 weeks). The interval in the 63 cases with chemotherapy-related delay was 12-63 weeks (mean, 31 weeks; P < .001). Ten of the 11 cases with an in breast relapse were in the group treated without a delay (P = .57). CONCLUSION: Delaying radiation therapy for chemotherapy does not compromise local control.


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