Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kalapurakal, J. A.
Right arrow Articles by Thomas, P. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kalapurakal, J. A.
Right arrow Articles by Thomas, P. R.

Radiology, Vol 204, 461-465, Copyright © 1997 by Radiological Society of North America

ARTICLES

Intracranial meningiomas: factors that influence the development of cerebral edema after stereotactic radiosurgery and radiation therapy

JA Kalapurakal, CL Silverman, N Akhtar, DW Laske, LE Braitman, OB Boyko and PR Thomas
Department of Radiation Oncology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

PURPOSE: To evaluate causative factors of cerebral edema after stereotactic radiosurgery or stereotactic radiation therapy in intracranial meningiomas. MATERIALS AND METHODS: Of 43 adult patients with intracranial meningiomas, three received 13.5-18-Gy single- fraction stereotactic radiosurgery; one received 19.8 Gy in three fractions, one received 42 Gy in six fractions, and 31 received 32-36 Gy in six to eight fractions of stereotactic radiation therapy; and seven received 45-54-Gy external-beam radiation with 20-28 Gy in five to seven fractions as concomitant stereotactic boosts. Brain edema was estimated by calculating the edema index. RESULTS: After irradiation, all 11 patients with parasagittal and four patients with nonparasagittal tumors developed worsening cerebral edema that necessitated the administration of steroids (P < .001). The statistically significant factors for the development of edema were parasagittal location, presence of pretreatment edema, sagittal sinus occlusion, and the use of more than 6 Gy per fraction. Five patients with parasagittal tumors developed life-threatening panhemispheric edema, which was fatal in one. The causative factors of panhemispheric edema were a large tumor, single-fraction stereotactic radiosurgery, or use of more than 6 Gy per fraction. CONCLUSION: A smaller dose per fraction and aggressive use of steroids may help prevent life- threatening complications due to worsening edema.


This article has been cited by other articles:


Home page
 Neuro OncolHome page
J. Julow, Z. Kolumban, A. Viola, T. Major, and G. Kolumban
Prediction of volumetric change in the "triple ring" caused by glioma I-125 brachytherapy
Neuro-oncol, August 1, 2008; 10(4): 583 - 592.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J H Chang, J W Chang, J Y Choi, Y G Park, and S S Chung
Complications after gamma knife radiosurgery for benign meningiomas
J. Neurol. Neurosurg. Psychiatry, February 1, 2003; 74(2): 226 - 230.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. A. Kalapurakal, Z. Ilahi, A. G. Kepka, T. Bista, S. Goldman, T. Tomita, and M. H. Marymont
Repositioning Accuracy with the Laitinen Frame for Fractionated Stereotactic Radiation Therapy in Adult and Pediatric Brain Tumors: Preliminary Report
Radiology, January 1, 2001; 218(1): 157 - 161.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
RADIOLOGY RADIOGRAPHICS RSNA JOURNALS ONLINE
Copyright © 1997 by the Radiological Society of North America.