| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Radiology, Vol 204, 661-666, Copyright © 1997 by Radiological Society of North America
ARTICLES |
WB Mackinnon, PA Barry, PL Malycha, DJ Gillett, P Russell, CL Lean, ST Doran, BH Barraclough, M Bilous and CE Mountford
Institute for Magnetic Resonance Research, University of Sydney, NSW, Australia.
PURPOSE: To determine whether invasive breast cancer can be distinguished from benign lesions with proton magnetic resonance (MR) spectroscopy ex vivo on the basis of altered cellular chemistry. MATERIALS AND METHODS: Two hundred eighteen fine-needle biopsy specimens were obtained in 191 patients undergoing surgery and were analyzed with proton MR spectroscopy. MR spectroscopic and histopathologic findings were compared. RESULTS: Invasive carcinoma produced increased signal at 3.25 ppm, attributable to choline- containing metabolites. Discrimination between invasive carcinoma (n = 82), benign lesions (n = 106), or carcinoma in situ (n = 17) was based on the resonance intensity at 3.25 ppm standardized to the resonance at 3.05 ppm (P < .001). The ratio of peak height intensities of resonances at 3.25 to those at 3.05 ppm was less than 1.7 in 102 of the 106 normal or benign lesions. All carcinoma in situ specimens with comedonecrosis or a microinvasive component (n = 6) were categorized at MR spectroscopy with invasive carcinoma, while others with in situ disease alone were categorized with benign lesions (n = 11). The sensitivity and specificity of MR spectroscopy in fine-needle biopsy specimens in distinguishing benign lesions from invasive cancer were 95% and 96%, respectively. CONCLUSION: Proton MR spectroscopy of fine-needle biopsy specimens provides objective diagnostic information that complements findings of conventional preoperative investigations of breast lesions.
This article has been cited by other articles:
|
|
 |
|
  J. Wang, P.-L. Torng, T.-P. Liu, K.-L. Chen, and T. T.-F. Shih Proton MR Spectroscopy in Normal Breasts Between Pre- and Postmenopausal Women: A Preliminary Study Am. J. Roentgenol., February 1, 2008; 190(2): 505 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bartella, E. A. Morris, D. D. Dershaw, L. Liberman, S. B. Thakur, C. Moskowitz, J. Guido, and W. Huang Proton MR Spectroscopy with Choline Peak as Malignancy Marker Improves Positive Predictive Value for Breast Cancer Diagnosis: Preliminary Study Radiology, June 1, 2006; 239(3): 686 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Stretch, R. Somorjai, R. Bourne, E. Hsiao, R. A. Scolyer, B. Dolenko, J. F. Thompson, C. E. Mountford, and C. L. Lean Melanoma Metastases in Regional Lymph Nodes Are Accurately Detected by Proton Magnetic Resonance Spectroscopy of Fine-Needle Aspirate Biopsy Samples Ann. Surg. Oncol., November 1, 2005; 12(11): 943 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bezabeh, O. Odlum, R. Nason, P. Kerr, D. Sutherland, R. Patel, and I. C.P. Smith Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 2108 - 2113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Meisamy, P. J. Bolan, E. H. Baker, M. G. Pollema, C. T. Le, F. Kelcz, M. C. Lechner, B. A. Luikens, R. A. Carlson, K. R. Brandt, et al. Adding in Vivo Quantitative 1H MR Spectroscopy to Improve Diagnostic Accuracy of Breast MR Imaging: Preliminary Results of Observer Performance Study at 4.0 T Radiology, August 1, 2005; 236(2): 465 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Meisamy, P. J. Bolan, E. H. Baker, R. L. Bliss, E. Gulbahce, L. I. Everson, M. T. Nelson, T. H. Emory, T. M. Tuttle, D. Yee, et al. Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer: Predicting Response with in Vivo 1H MR Spectroscopy--A Pilot Study at 4 T Radiology, November 1, 2004; 233(2): 424 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Wang, C.-W. Li, T.-J. Hsieh, S.-H. Chien, G.-C. Liu, and K.-B. Tsai Characterization of Bone and Soft-Tissue Tumors with in Vivo 1H MR Spectroscopy: Initial Results Radiology, August 1, 2004; 232(2): 599 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. K. Tse, H. S. Cheung, L.-M. Pang, W. C. W. Chu, B. K. B. Law, F. Y. L. Kung, and D. K. W. Yeung Characterization of Lesions of the Breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors Am. J. Roentgenol., November 1, 2003; 181(5): 1267 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Swindle, S. McCredie, P. Russell, U. Himmelreich, M. Khadra, C. Lean, and C. Mountford Pathologic Characterization of Human Prostate Tissue with Proton MR Spectroscopy Radiology, July 1, 2003; 228(1): 144 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. W. Yeung, W.-T. Yang, and G. M. K. Tse Breast Cancer: In Vivo Proton MR Spectroscopy in the Characterization of Histopathologic Subtypes and Preliminary Observations in Axillary Node Metastases Radiology, October 1, 2002; 225(1): 190 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Katz-Brull, P. T. Lavin, and R. E. Lenkinski Clinical Utility of Proton Magnetic Resonance Spectroscopy in Characterizing Breast Lesions J Natl Cancer Inst, August 21, 2002; 94(16): 1197 - 1203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. W. Yeung, H. S. Cheung, and G. M. K. Tse Human Breast Lesions: Characterization with Contrast-enhanced in Vivo Proton MR Spectroscopy—Initial Results Radiology, July 1, 2001; 220(1): 40 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Himmelreich, T. E. Dzendrowskyj, C. Allen, S. Dowd, R. Malik, B. P. Shehan, P. Russell, C. E. Mountford, and T. C. Sorrell Cryptococcomas Distinguished from Gliomas with MR Spectroscopy: An Experimental Rat and Cell Culture Study Radiology, July 1, 2001; 220(1): 122 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Maheshwari, S. K. Mukherji, B. Neelon, S. Schiro, G. M. Fatterpekar, J. A. Stone, and M. Castillo The Choline/Creatine Ratio in Five Benign Neoplasms: Comparison with Squamous Cell Carcinoma by Use of in Vitro MR Spectroscopy AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1930 - 1935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Gerstle, S. R. Aylward, S. Kromhout-Schiro, and S. K. Mukherji The Role of Neural Networks in Improving the Accuracy of MR Spectroscopy for the Diagnosis of Head and Neck Squamous Cell Carcinoma AJNR Am. J. Neuroradiol., June 1, 2000; 21(6): 1133 - 1138. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. O. Aboagye and Z. M. Bhujwalla Malignant Transformation Alters Membrane Choline Phospholipid Metabolism of Human Mammary Epithelial Cells Cancer Res., January 1, 1999; 59(1): 80 - 84. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
