Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by von Kummer, R.
Right arrow Articles by Hacke, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by von Kummer, R.
Right arrow Articles by Hacke, W.

Radiology, Vol 205, 327-333, Copyright © 1997 by Radiological Society of North America

ARTICLES

Acute stroke: usefulness of early CT findings before thrombolytic therapy

R von Kummer, KL Allen, R Holle, L Bozzao, S Bastianello, C Manelfe, E Bluhmki, P Ringleb, DH Meier and W Hacke
Department of Neuroradiology, Technische Universitat, Dresden, Germany.

PURPOSE: To determine whether the extent of subtle parenchymal hypoattenuation detected on computed tomographic (CT) scans obtained within 6 hours of ischemic stroke is a factor in predicting patients' response to thrombolytic treatment. MATERIALS AND METHODS: The baseline CT scans of 620 patients, who received either recombinant tissue plasminogen activator (rt-PA) or a placebo, in a double-blind, randomized multicenter trial were prospectively evaluated and assigned to one of three categories according to the extent of parenchymal hypoattenuation: none, 33% or less (small), or more than 33% (large) of the middle cerebral artery territory. The association between the extent of hypoattenuation on the baseline CT scans and the clinical outcome in the placebo-treated and the rt-PA-treated groups after 3 months was analyzed. RESULTS: In 215 patients with a small hypoattenuating area, treatment increased the chance of good outcome. In 336 patients with a normal CT scan and in 52 patients with a large hypoattenuating area, rt-PA had no beneficial effect but increased the risk for fatal brain hemorrhage. CONCLUSION: The response to rt-PA in patients with ischemic stroke can be predicted on the basis of initial CT findings of the extent of parenchymal hypoattenuation in the territory of the middle cerebral artery.


This article has been cited by other articles:


Home page
 Emerg. Med. J.Home page
J Kendall
Thrombolysis for acute ischaemic stroke: a new challenge for emergency medicine
Emerg. Med. J., August 1, 2008; 25(8): 471 - 475.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
O. Ozdemir, A. Leung, M. Bussiere, V. Hachinski, and D. Pelz
Hyperdense Internal Carotid Artery Sign: A CT Sign of Acute Ischemia
Stroke, July 1, 2008; 39(7): 2011 - 2016.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
K. Nedeltchev, B. Schwegler, T. Haefeli, C. Brekenfeld, J. Gralla, U. Fischer, M. Arnold, L. Remonda, G. Schroth, and H. P. Mattle
Outcome of Stroke With Mild or Rapidly Improving Symptoms
Stroke, September 1, 2007; 38(9): 2531 - 2535.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
T. G. Phan, MBBS, FRACP, A. C. Fong, G. Donnan, and D. C. Reutens
Digital Map of Posterior Cerebral Artery Infarcts Associated With Posterior Cerebral Artery Trunk and Branch Occlusion
Stroke, June 1, 2007; 38(6): 1805 - 1811.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. P. Adams Jr, G. del Zoppo, M. J. Alberts, D. L. Bhatt, L. Brass, A. Furlan, R. L. Grubb, R. T. Higashida, E. C. Jauch, C. Kidwell, et al.
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.
Circulation, May 22, 2007; 115(20): e478 - e534.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
I. Dzialowski, E. Klotz, S. Goericke, A. Doerfler, M. Forsting, and R. von Kummer
Ischemic Brain Tissue Water Content: CT Monitoring during Middle Cerebral Artery Occlusion and Reperfusion in Rats
Radiology, May 1, 2007; 243(3): 720 - 726.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. P. Adams Jr, G. del Zoppo, M. J. Alberts, D. L. Bhatt, L. Brass, A. Furlan, R. L. Grubb, R. T. Higashida, E. C. Jauch, C. Kidwell, et al.
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Stroke, May 1, 2007; 38(5): 1655 - 1711.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. W. Parsons, E. M. Pepper, G. A. Bateman, Y. Wang, and C. R. Levi
Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT
Neurology, March 6, 2007; 68(10): 730 - 736.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
K. S. Butcher, S. B. Lee, M. W. Parsons, L. Allport, J. Fink, B. Tress, G. Donnan, S. M. Davis, and for the EPITHET Investigators
Differential Prognosis of Isolated Cortical Swelling and Hypoattenuation on CT in Acute Stroke
Stroke, March 1, 2007; 38(3): 941 - 947.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E.Y. Kim, J.W. Ryoo, H.G. Roh, K.H. Lee, S.S. Kim, I.C. Song, K.-H. Chang, and D.G. Na
Reversed Discrepancy between CT and Diffusion-Weighted MR Imaging in Acute Ischemic Stroke.
AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1990 - 1995.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. K. Shetty
The MCA Dot Sign
Radiology, October 1, 2006; 241(1): 315 - 318.
[Full Text] [PDF]

Home page
 StrokeHome page
T. Neumann-Haefelin, S. Hoelig, J. Berkefeld, J. Fiehler, A. Gass, M. Humpich, A. Kastrup, T. Kucinski, O. Lecei, D. S. Liebeskind, et al.
Leukoaraiosis Is a Risk Factor for Symptomatic Intracerebral Hemorrhage After Thrombolysis for Acute Stroke
Stroke, October 1, 2006; 37(10): 2463 - 2466.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
I. Dzialowski, M. D. Hill, S. B. Coutts, A. M. Demchuk, D. M. Kent, O. Wunderlich, and R. von Kummer
Extent of Early Ischemic Changes on Computed Tomography (CT) Before Thrombolysis: Prognostic Value of the Alberta Stroke Program Early CT Score in ECASS II
Stroke, April 1, 2006; 37(4): 973 - 978.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
P L Tan, D King, C J Durkin, T M Meagher, and D Briley
Diffusion weighted magnetic resonance imaging for acute stroke: practical and popular.
Postgrad. Med. J., April 1, 2006; 82(966): 289 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C. Tanaka, T. Ueguchi, E. Shimosegawa, N. Sasaki, T. Johkoh, H. Nakamura, and J. Hatazawa
Effect of CT Acquisition Parameters in the Detection of Subtle Hypoattenuation in Acute Cerebral Infarction: A Phantom Study
AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 40 - 45.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
T. Hirano, T. Yonehara, Y. Inatomi, Y. Hashimoto, and M. Uchino
Presence of Early Ischemic Changes on Computed Tomography Depends on Severity and the Duration of Hypoperfusion: A Single Photon Emission-Computed Tomographic Study
Stroke, December 1, 2005; 36(12): 2601 - 2608.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P A Barber, M D Hill, M Eliasziw, A M Demchuk, J H W Pexman, M E Hudon, A Tomanek, R Frayne, A M Buchan, and for the ASPEC Study Group
Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging
J. Neurol. Neurosurg. Psychiatry, November 1, 2005; 76(11): 1528 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M Arnold, K Nedeltchev, L Remonda, U Fischer, C Brekenfeld, B Keserue, G Schroth, and H P Mattle
Recanalisation of middle cerebral artery occlusion after intra-arterial thrombolysis: different recanalisation grading systems and clinical functional outcome
J. Neurol. Neurosurg. Psychiatry, October 1, 2005; 76(10): 1373 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A. M. Demchuk, M. D. Hill, P. A. Barber, B. Silver, S. C. Patel, S. R. Levine, and for the NINDS rtPA Stroke Study Group, NIH
Importance of Early Ischemic Computed Tomography Changes Using ASPECTS in NINDS rtPA Stroke Study
Stroke, October 1, 2005; 36(10): 2110 - 2115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
L. H. Schwamm, E. S. Rosenthal, C. J. Swap, J. Rosand, G. Rordorf, F. S. Buonanno, M. G. Vangel, W. J. Koroshetz, and M. H. Lev
Hypoattenuation on CT Angiographic Source Images Predicts Risk of Intracerebral Hemorrhage and Outcome after Intra-Arterial Reperfusion Therapy
AJNR Am. J. Neuroradiol., August 1, 2005; 26(7): 1798 - 1803.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
D. M. Kent, M. D. Hill, R. Ruthazer, S. B. Coutts, A. M. Demchuk, I. Dzialowski, O. Wunderlich, and R. von Kummer
"Clinical-CT Mismatch" and the Response to Systemic Thrombolytic Therapy in Acute Ischemic Stroke
Stroke, August 1, 2005; 36(8): 1695 - 1699.
[Abstract] [Full Text] [PDF]

Home page
 Neurorehabil Neural RepairHome page
S. K. Schiemanck, M. W.M. Post, Th. D. Witkamp, L. J. Kappelle, and A. J.H. Prevo
Relationship between Ischemic Lesion Volume and Functional Status in the 2nd Week after Middle Cerebral Artery Stroke
Neurorehabil Neural Repair, June 1, 2005; 19(2): 133 - 138.
[Abstract] [PDF]

Home page
 RadiologyHome page
D. G. Na, E. Y. Kim, J. W. Ryoo, K. H. Lee, H. G. Roh, S. S. Kim, I. C. Song, and K.-H. Chang
CT Sign of Brain Swelling without Concomitant Parenchymal Hypoattenuation: Comparison with Diffusion- and Perfusion-weighted MR Imaging
Radiology, June 1, 2005; 235(3): 992 - 948.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. Y. Kim, D. G. Na, S. S. Kim, K. H. Lee, J. W. Ryoo, and H. K. Kim
Prediction of Hemorrhagic Transformation in Acute Ischemic Stroke: Role of Diffusion-Weighted Imaging and Early Parenchymal Enhancement
AJNR Am. J. Neuroradiol., May 1, 2005; 26(5): 1050 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. M. Wardlaw and O. Mielke
Early Signs of Brain Infarction at CT: Observer Reliability and Outcome after Thrombolytic Treatment--Systematic Review
Radiology, May 1, 2005; 235(2): 444 - 453.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
T. G. Phan, G. A. Donnan, P. M. Wright, and D. C. Reutens
A Digital Map of Middle Cerebral Artery Infarcts Associated With Middle Cerebral Artery Trunk and Branch Occlusion
Stroke, May 1, 2005; 36(5): 986 - 991.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. B. Coutts, M. H. Lev, M. Eliasziw, L. Roccatagliata, M. D. Hill, L. H. Schwamm, J.H. W. Pexman, W. J. Koroshetz, M. E. Hudon, A. M. Buchan, et al.
ASPECTS on CTA Source Images Versus Unenhanced CT: Added Value in Predicting Final Infarct Extent and Clinical Outcome
Stroke, November 1, 2004; 35(11): 2472 - 2476.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P A Barber, A M Demchuk, M D Hill, J H W. Pexman, M E Hudon, R Frayne, and A M Buchan
The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studies
J. Neurol. Neurosurg. Psychiatry, October 1, 2004; 75(10): 1426 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
D. M. Somford, M. P. Marks, V. N. Thijs, and D. C. Tong
Association of Early CT Abnormalities, Infarct Size, and Apparent Diffusion Coefficient Reduction in Acute Ischemic Stroke
AJNR Am. J. Neuroradiol., June 1, 2004; 25(6): 933 - 938.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
E. G. Hoeffner, I. Case, R. Jain, S. K. Gujar, G. V. Shah, J. P. Deveikis, R. C. Carlos, B. G. Thompson, M. R. Harrigan, and S. K. Mukherji
Cerebral Perfusion CT: Technique and Clinical Applications
Radiology, June 1, 2004; 231(3): 632 - 644.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. B. Coutts, A. M. Demchuk, P. A. Barber, W. Y. Hu, J. E. Simon, A. M. Buchan, M. D. Hill, and for the VISION Study Group
Interobserver Variation of ASPECTS in Real Time
Stroke, May 1, 2004; 35(5): e103 - e105.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Arnold, K. Nedeltchev, C. Brekenfeld, U. Fischer, L. Remonda, G. Schroth, and H. Mattle
Outcome of Acute Stroke Patients Without Visible Occlusion on Early Arteriography
Stroke, May 1, 2004; 35(5): 1135 - 1138.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
S. J. Lee, K. H. Lee, D. G. Na, H. S. Byun, Y. B. Kim, Y.-M. Shon, S.-J. Cho, J. Lee, C.-S. Chung, and S.-C. Hong
Multiphasic Helical Computed Tomography Predicts Subsequent Development of Severe Brain Edema in Acute Ischemic Stroke
Arch Neurol, April 1, 2004; 61(4): 505 - 509.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
G. F. Hamann, A. J. Furlan, and R. T. Higashida
Early Ischemic Signs Should Not Be Used as Exclusion Criteria in Thrombolysis Trials * Response
Stroke, January 1, 2004; 35 (1): e3 - e4.
[Full Text] [PDF]

Home page
 StrokeHome page
J. Montaner, I. Fernandez-Cadenas, C. A. Molina, J. Monasterio, J. F. Arenillas, M. Ribo, M. Quintana, P. Chacon, A. L. Andreu, and J. Alvarez-Sabin
Safety Profile of Tissue Plasminogen Activator Treatment Among Stroke Patients Carrying a Common Polymorphism (C-1562T) in the Promoter Region of the Matrix Metalloproteinase-9 Gene
Stroke, December 1, 2003; 34(12): 2851 - 2855.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. M. Provenzale, R. Jahan, T. P. Naidich, and A. J. Fox
Assessment of the Patient with Hyperacute Stroke: Imaging and Therapy
Radiology, November 1, 2003; 229(2): 347 - 359.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. B. Coutts, M. D. Hill, A. M. Demchuk, P. A. Barber, J.H. W. Pexman, A. M. Buchan, H. K.F. Mak, K. K.W. Yau, and B. P.L. Chan
ASPECTS Reading Requires Training and Experience * Response
Stroke, October 1, 2003; 34 (10): e179 - e179.
[Full Text] [PDF]

Home page
 StrokeHome page
M. D. Hill, H. A. Rowley, F. Adler, M. Eliasziw, A. Furlan, R. T. Higashida, L. R. Wechsler, H. C. Roberts, W. P. Dillon, N. J. Fischbein, et al.
Selection of Acute Ischemic Stroke Patients for Intra-Arterial Thrombolysis With Pro-Urokinase by Using ASPECTS
Stroke, August 1, 2003; 34(8): 1925 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M Arnold, K Nedeltchev, H P Mattle, T J Loher, F Stepper, G Schroth, C Brekenfeld, M Sturzenegger, and L Remonda
Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions
J. Neurol. Neurosurg. Psychiatry, June 1, 2003; 74(6): 739 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
D. Saur, T. Kucinski, U. Grzyska, B. Eckert, C. Eggers, W. Niesen, V. Schoder, H. Zeumer, C. Weiller, and J. Rother
Sensitivity and Interrater Agreement of CT and Diffusion-Weighted MR Imaging in Hyperacute Stroke
AJNR Am. J. Neuroradiol., May 1, 2003; 24(5): 878 - 885.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M Koga, Y Saku, K Toyoda, H Takaba, S Ibayashi, and M Iida
Reappraisal of early CT signs to predict the arterial occlusion site in acute embolic stroke
J. Neurol. Neurosurg. Psychiatry, May 1, 2003; 74(5): 649 - 653.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Alvarez-Sabin, C. A. Molina, J. Montaner, J. F. Arenillas, R. Huertas, M. Ribo, A. Codina, and M. Quintana
Effects of Admission Hyperglycemia on Stroke Outcome in Reperfused Tissue Plasminogen Activator-Treated Patients
Stroke, May 1, 2003; 34(5): 1235 - 1240.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. K.F. Mak, K. K.W. Yau, P.-L. Khong, A. S.C. Ching, P.-W. Cheng, P. K.M. Au-Yeung, P. K.M. Pang, K. C.W. Wong, and B. P.L. Chan
Hypodensity of >1/3 Middle Cerebral Artery Territory Versus Alberta Stroke Programme Early CT Score (ASPECTS): Comparison of Two Methods of Quantitative Evaluation of Early CT Changes in Hyperacute Ischemic Stroke in the Community Setting
Stroke, May 1, 2003; 34(5): 1194 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J M Wardlaw, T M West, P A G Sandercock, S C Lewis, and O Mielke
Visible infarction on computed tomography is an independent predictor of poor functional outcome after stroke, and not of haemorrhagic transformation
J. Neurol. Neurosurg. Psychiatry, April 1, 2003; 74(4): 452 - 458.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. P. Adams Jr, R. J. Adams, T. Brott, G. J. del Zoppo, A. Furlan, L. B. Goldstein, R. L. Grubb, R. Higashida, C. Kidwell, T. G. Kwiatkowski, et al.
Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association
Stroke, April 1, 2003; 34(4): 1056 - 1083.
[Full Text] [PDF]

Home page
 StrokeHome page
R. von Kummer
Early Major Ischemic Changes on Computed Tomography Should Preclude Use of Tissue Plasminogen Activator
Stroke, March 1, 2003; 34(3): 820 - 821.
[Full Text] [PDF]

Home page
 StrokeHome page
P. Lyden
Early Major Ischemic Changes on Computed Tomography Should Not Preclude Use of Tissue Plasminogen Activator
Stroke, March 1, 2003; 34(3): 821 - 822.
[Full Text]

Home page
 CirculationHome page
J. Montaner, C. A. Molina, J. Monasterio, S. Abilleira, J. F. Arenillas, M. Ribo, M. Quintana;, and J. Alvarez-Sabin
Matrix Metalloproteinase-9 Pretreatment Level Predicts Intracranial Hemorrhagic Complications After Thrombolysis in Human Stroke
Circulation, February 4, 2003; 107(4): 598 - 603.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. D. Schellinger, J. B. Fiebach, W. Hacke, and J. Rother
Imaging-Based Decision Making in Thrombolytic Therapy for Ischemic Stroke: Present Status
Stroke, February 1, 2003; 34(2): 575 - 583.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. F. Arenillas, A. Rovira, C. A. Molina, E. Grive, J. Montaner, J. Alvarez-Sabin, and K.-O. Lovblad
Prediction of Early Neurological Deterioration Using Diffusion- and Perfusion-Weighted Imaging in Hyperacute Middle Cerebral Artery Ischemic Stroke * Editorial Comment
Stroke, September 1, 2002; 33(9): 2197 - 2205.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A.K. Gilligan, R. Markus, S. Read, V. Srikanth, T. Hirano, G. Fitt, M. Arends, B.R. Chambers, S.M. Davis, and G.A. Donnan
Baseline Blood Pressure but Not Early Computed Tomography Changes Predicts Major Hemorrhage After Streptokinase in Acute Ischemic Stroke
Stroke, September 1, 2002; 33(9): 2236 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. E. Mullins, P. W. Schaefer, A. G. Sorensen, E. F. Halpern, H. Ay, J. He, W. J. Koroshetz, and R. G. Gonzalez
CT and Conventional and Diffusion-weighted MR Imaging in Acute Stroke: Study in 691 Patients at Presentation to the Emergency Department
Radiology, August 1, 2002; 224(2): 353 - 360.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Arnold, G. Schroth, K. Nedeltchev, T. Loher, L. Remonda, F. Stepper, M. Sturzenegger, and H. P. Mattle
Intra-Arterial Thrombolysis in 100 Patients With Acute Stroke Due to Middle Cerebral Artery Occlusion
Stroke, July 1, 2002; 33(7): 1828 - 1833.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. A. Molina, J. Alvarez-Sabin, J. Montaner, S. Abilleira, J. F. Arenillas, P. Coscojuela, F. Romero, and A. Codina
Thrombolysis-Related Hemorrhagic Infarction: A Marker of Early Reperfusion, Reduced Infarct Size, and Improved Outcome in Patients With Proximal Middle Cerebral Artery Occlusion
Stroke, June 1, 2002; 33(6): 1551 - 1556.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. C. Roberts, W. P. Dillon, A. J. Furlan, L. R. Wechsler, H. A. Rowley, N. J. Fischbein, R. T. Higashida, C. Kase, G. A. Schulz, Y. Lu, et al.
Computed Tomographic Findings in Patients Undergoing Intra-arterial Thrombolysis for Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: Results From the PROACT II Trial * Editorial Comment: Results From the PROACT II Trial
Stroke, June 1, 2002; 33(6): 1557 - 1565.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P.A. Ringleb, P.D. Schellinger, C. Schranz, and W. Hacke
Thrombolytic Therapy Within 3 to 6 Hours After Onset of Ischemic Stroke: Useful or Harmful?
Stroke, May 1, 2002; 33(5): 1437 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
N. Nighoghossian, M. Hermier, P. Adeleine, K. Blanc-Lasserre, L. Derex, J. Honnorat, F. Philippeau, J.F. Dugor, J.C. Froment, and P. Trouillas
Old Microbleeds Are a Potential Risk Factor for Cerebral Bleeding After Ischemic Stroke: A Gradient-Echo T2*-Weighted Brain MRI Study
Stroke, March 1, 2002; 33(3): 735 - 742.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
S. C. Patel, S. R. Levine, B. C. Tilley, J. C. Grotta, M. Lu, M. Frankel, E. C. Haley Jr, T. G. Brott, J. P. Broderick, S. Horowitz, et al.
Lack of Clinical Significance of Early Ischemic Changes on Computed Tomography in Acute Stroke
JAMA, December 12, 2001; 286(22): 2830 - 2838.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. A. Molina, J. Montaner, S. Abilleira, J. F. Arenillas, M. Ribo, R. Huertas, F. Romero, and J. Alvarez-Sabin
Time Course of Tissue Plasminogen Activator-Induced Recanalization in Acute Cardioembolic Stroke: A Case-Control Study
Stroke, December 1, 2001; 32(12): 2821 - 2827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. H. W. Pexman, P. A. Barber, M. D. Hill, R. J. Sevick, A. M. Demchuk, M. E. Hudon, W. Y. Hu, and A. M. Buchan
Use of the Alberta Stroke Program Early CT Score (ASPECTS) for Assessing CT Scans in Patients with Acute Stroke
AJNR Am. J. Neuroradiol., September 1, 2001; 22(8): 1534 - 1542.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. H. Lev, A. Z. Segal, J. Farkas, S. T. Hossain, C. Putman, G. J. Hunter, R. Budzik, G. J. Harris, F. S. Buonanno, M. A. Ezzeddine, et al.
Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:: Prediction of Final Infarct Volume and Clinical Outcome Editorial Comment: Prediction of Final Infarct Volume and Clinical Outcome
Stroke, September 1, 2001; 32(9): 2021 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. Nakano, T. Iseda, H. Kawano, T. Yoneyama, T. Ikeda, and S. Wakisaka
Parenchymal Hyperdensity on Computed Tomography After Intra-Arterial Reperfusion Therapy for Acute Middle Cerebral Artery Occlusion: Incidence and Clinical Significance
Stroke, September 1, 2001; 32(9): 2042 - 2048.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. E. Kasner, A. M. Demchuk, J. Berrouschot, E. Schmutzhard, L. Harms, P. Verro, J. A. Chalela, R. Abbur, H. McGrade, I. Christou, et al.
Predictors of Fatal Brain Edema in Massive Hemispheric Ischemic Stroke
Stroke, September 1, 2001; 32(9): 2117 - 2123.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. W. Albers
Advances in intravenous thrombolytic therapy for treatment of acute stroke
Neurology, September 1, 2001; 57(90002): S77 - 81.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
J. A. Maldjian, J. Chalela, S. E. Kasner, D. Liebeskind, and J. A. Detre
Automated CT Segmentation and Analysis for Acute Middle Cerebral Artery Stroke
AJNR Am. J. Neuroradiol., June 1, 2001; 22(6): 1050 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
J H Gillard, N M Antoun, N G Burnet, and J D Pickard
Reproducibility of quantitative CT perfusion imaging
Br. J. Radiol., June 1, 2001; 74(882): 552 - 555.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. Berger, M. Fiorelli, T. Steiner, W.-R. Schabitz, L. Bozzao, E. Bluhmki, W. Hacke, and R. von Kummer
Hemorrhagic Transformation of Ischemic Brain Tissue : Asymptomatic or Symptomatic?
Stroke, June 1, 2001; 32(6): 1330 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. A. Molina, J. Montaner, S. Abilleira, B. Ibarra, F. Romero, J. F. Arenillas, and J. Alvarez-Sabin
Timing of Spontaneous Recanalization and Risk of Hemorrhagic Transformation in Acute Cardioembolic Stroke
Stroke, May 1, 2001; 32(5): 1079 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. C. Tong, A. Adami, M. E. Moseley, and M. P. Marks
Prediction of Hemorrhagic Transformation Following Acute Stroke: Role of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging
Arch Neurol, April 1, 2001; 58(4): 587 - 593.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. von Kummer, H. Bourquain, S. Bastianello, L. Bozzao, C. Manelfe, D. Meier, and W. Hacke
Early Prediction of Irreversible Brain Damage after Ischemic Stroke at CT
Radiology, April 1, 2001; 219(1): 95 - 100.
[Abstract] [Full Text]

Home page
 BrainHome page
W.-D. Heiss, L. W. Kracht, A. Thiel, M. Grond, and G. Pawlik
Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia
Brain, January 1, 2001; 124(1): 20 - 29.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. C. Diener, E. B. Ringelstein, R. von Kummer, H. D. Langohr, H. Bewermeyer, H. Landgraf, M. Hennerici, D. Welzel, M. Grave, J. Brom, et al.
Treatment of Acute Ischemic Stroke With the Low-Molecular-Weight Heparin Certoparin : Results of the TOPAS Trial
Stroke, January 1, 2001; 32(1): 22 - 29.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. A. Barber, A. M. Demchuk, M. E. Hudon, J.H. W. Pexman, M. D. Hill, and A. M. Buchan
Hyperdense Sylvian Fissure MCA "Dot" Sign : A CT Marker of Acute Ischemia
Stroke, January 1, 2001; 32(1): 84 - 88.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. von Kummer, G. Gahn, M. P. Marks, G. Albers, and M. Lansberg
Comparison of diffusion-weighted MRI and CT in acute stroke
Neurology, December 12, 2000; 55(11): 1760 - 1760.
[Full Text] [PDF]

Home page
 StrokeHome page
C. Baracchini, R. Manara, M. Ermani, and G. Meneghetti
The Quest for Early Predictors of Stroke Evolution : Can TCD Be a Guiding Light?
Stroke, December 1, 2000; 31(12): 2942 - 2947.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
D. C. Tong, A. Adami, M. E. Moseley, and M. P. Marks
Relationship Between Apparent Diffusion Coefficient and Subsequent Hemorrhagic Transformation Following Acute Ischemic Stroke
Stroke, October 1, 2000; 31(10): 2378 - 2384.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
R. von Kummer, S. C. Jones, T. A. Kent, and D. K. Kim
The Time Concept in Ischemic Stroke: Misleading Response
Stroke, October 1, 2000; 31 (10): 2517 - 2527.
[Full Text] [PDF]

Home page
 NEJMHome page
T. Brott and J. Bogousslavsky
Treatment of Acute Ischemic Stroke
N. Engl. J. Med., September 7, 2000; 343(10): 710 - 722.
[Full Text] [PDF]

Home page
 RadiologyHome page
R. von Kummer, N. J. Beauchamp Jr, P. B. Barker, P. Y. Wang, and P. C. M. vanZijl
CT of Acute Cerebral Ischemia Dr Beauchamp and colleagues respond:
Radiology, August 1, 2000; 216(2): 611 - 613.
[Full Text]

Home page
 Arch NeurolHome page
K. H. Lee, S.-J. Cho, H. S. Byun, D. G. Na, N.-C. Choi, S. J. Lee, I.-S. Jin, T. G. Lee, and C.-S. Chung
Triphasic Perfusion Computed Tomography in Acute Middle Cerebral Artery Stroke: A Correlation With Angiographic Findings
Arch Neurol, July 1, 2000; 57(7): 990 - 999.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
K. H. Lee, S. J. Lee, S.-J. Cho, D. G. Na, H. S. Byun, Y.-B. Kim, H.-J. Song, I.-S. Jin, and C.-S. Chung
Usefulness of Triphasic Perfusion Computed Tomography for Intravenous Thrombolysis With Tissue-Type Plasminogen Activator in Acute Ischemic Stroke
Arch Neurol, July 1, 2000; 57(7): 1000 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. A. Kalafut, D. L. Schriger, J. L. Saver, and S. Starkman
Detection of Early CT Signs of >1/3 Middle Cerebral Artery Infarctions : Interrater Reliability and Sensitivity of CT Interpretation by Physicians Involved in Acute Stroke Care
Stroke, July 1, 2000; 31(7): 1667 - 1671.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. G. Lansberg, G. W. Albers, C. Beaulieu, and M. P. Marks
Comparison of diffusion-weighted MRI and CT in acute stroke
Neurology, April 25, 2000; 54(8): 1557 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. M. Buchan, P. A. Barber, N. Newcommon, H. G. Karbalai, A. M. Demchuk, K. M. Hoyte, G. M. Klein, and T. E. Feasby
Effectiveness of t-PA in acute ischemic stroke: Outcome relates to appropriateness
Neurology, February 8, 2000; 54(3): 679 - 679.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. Toni, F. Iweins, R. von Kummer, O. Busse, J. Bogousslavsky, A. Falcou, E. Lesaffre, and G. L. Lenzi
Identification of lacunar infarcts before thrombolysis in the ECASS I study
Neurology, February 8, 2000; 54(3): 684 - 684.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
W.-D. Heiss, L. Kracht, M. Grond, J. Rudolf, B. Bauer, K. Wienhard, and G. Pawlik
Early [11C]Flumazenil/H2O Positron Emission Tomography Predicts Irreversible Ischemic Cortical Damage in Stroke Patients Receiving Acute Thrombolytic Therapy
Stroke, February 1, 2000; 31(2): 366 - 369.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Grond, R. von Kummer, J. Sobesky, S. Schmulling, J. Rudolf, K. Terstegge, and W.-D. Heiss
Early X-Ray Hypoattenuation of Brain Parenchyma Indicates Extended Critical Hypoperfusion in Acute Stroke
Stroke, January 1, 2000; 31(1): 133 - 139.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
A. Furlan, R. Higashida, L. Wechsler, M. Gent, H. Rowley, C. Kase, M. Pessin, A. Ahuja, F. Callahan, W. M. Clark, et al.
Intra-arterial Prourokinase for Acute Ischemic Stroke: The PROACT II Study: A Randomized Controlled Trial
JAMA, December 1, 1999; 282(21): 2003 - 2011.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. Perl II, J. A. Tkach, M. Porras-Jimenez, M. Lieber, N. Obuchowski, J. S. Ross, X. P. Ding, P. M Ruggieri, D. M. Shearer, K. Khajavi, et al.
Hemorrhage Detected Using MR Imaging in the Setting of Acute Stroke: An In Vivo Model
AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1863 - 1870.
[Abstract] [Full Text]

Home page
 RadiologyHome page
M. H. Lev, J. Farkas, J. J. Gemmete, S. T. Hossain, G. J. Hunter, W. J. Koroshetz, and R. G. Gonzalez
Acute Stroke: Improved Nonenhanced CT Detection-Benefits of Soft-Copy Interpretation by Using Variable Window Width and Center Level Settings
Radiology, October 1, 1999; 213(1): 150 - 155.
[Abstract] [Full Text]

Home page
 StrokeHome page
P. A. Barber, D. G. Darby, P. M. Desmond, R. P. Gerraty, Q. Yang, T. Li, D. Jolley, G. A. Donnan, B. M. Tress, and S. M. Davis
Identification of Major Ischemic Change : Diffusion-Weighted Imaging Versus Computed Tomography
Stroke, October 1, 1999; 30(10): 2059 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
G. W. Albers
Expanding the Window for Thrombolytic Therapy in Acute Stroke : The Potential Role of Acute MRI for Patient Selection
Stroke, October 1, 1999; 30(10): 2230 - 2237.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. L. Sunshine, R. W. Tarr, C. F. Lanzieri, D. M. D. Landis, W. R. Selman, and J. S. Lewin
Hyperacute Stroke: Ultrafast MR Imaging to Triage Patients prior to Therapy
Radiology, August 1, 1999; 212(2): 325 - 332.
[Abstract] [Full Text]

Home page
 StrokeHome page
J. C. Grotta, D. Chiu, M. Lu, S. Patel, S. R. Levine, B. C. Tilley, T. G. Brott, E. C. Haley Jr, P. D. Lyden, R. Kothari, et al.
Agreement and Variability in the Interpretation of Early CT Changes in Stroke Patients Qualifying for Intravenous rtPA Therapy
Stroke, August 1, 1999; 30(8): 1528 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. O. Karonen, R. L. Vanninen, Y. Liu, L. Ostergaard, J. T. Kuikka, J. Nuutinen, E. J. Vanninen, P. L. K. Partanen, P. A. Vainio, K. Korhonen, et al.
Combined Diffusion and Perfusion MRI With Correlation to Single-Photon Emission CT in Acute Ischemic Stroke : Ischemic Penumbra Predicts Infarct Growth
Stroke, August 1, 1999; 30(8): 1583 - 1590.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Fisher and G. W. Albers
Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke
Neurology, June 1, 1999; 52(9): 1750 - 1750.
[Abstract] [Full Text]

Home page
 StrokeHome page
P. Pantano, F. Caramia, L. Bozzao, C. Dieler, and R. von Kummer
Delayed Increase in Infarct Volume After Cerebral Ischemia : Correlations with Thrombolytic Treatment and Clinical Outcome
Stroke, March 1, 1999; 30(3): 502 - 507.
[Abstract] [Full Text] [PDF]