Radiology, Vol 205, 721-728, Copyright © 1997 by Radiological Society of North America

ARTICLES

Hepatocellular carcinoma: evaluation with dynamic and static gadobenate dimeglumine-enhanced MR imaging and histopathologic correlation

TJ Vogl, A Stupavsky, W Pegios, R Hammerstingl, M Mack, T Diebold, KP Lodemann, P Neuhaus and R Felix
Department of Radiology, Rudolf Virchow Clinic, Humboldt-University of Berlin, Rudolf Virchow Hospital, Germany.

PURPOSE: To analyze the potential of gadobenate dimeglumine-enhanced magnetic resonance (MR) imaging for the characterization and diagnosis of hepatocellular carcinoma (HCC) by using static and dynamic sequences. MATERIALS AND METHODS: Twenty-eight patients with histopathologically proved HCC were evaluated with T1- and T2-weighted spin-echo and static and dynamic gradient-echo sequences before, during, and after intravenous administration of 0.1 mmol/kg gadobenate dimeglumine (0.5 mol/L). RESULTS: During the perfusion phase of the dynamic sequence, all 16 nodular well-differentiated HCC lesions showed a rapid increase in signal intensity 10-30 seconds after injection followed by a progressive decrease in signal intensity. The nine poorly differentiated HCC lesions showed no rapid increase in signal intensity. All eight large (> 3 cm), nodular, well-differentiated HCC lesions showed a hypointense rim before injection and both hypo- and hyperintense rims (double-ring sign) immediately after injection, compared with normal liver parenchyma. About 55 seconds after injection, substantial single-rim enhancement was detected in 21 of the 28 HCC lesions. CONCLUSION: Dynamic gadobenate dimeglumine-enhanced MR imaging allows improved characterization of HCC lesions, which show rapid increase in signal intensity during the early, arterial phase in well-differentiated HCC lesions and a double-ring sign in large well- differentiated nodular HCC lesions.

This article has been cited by other articles:

				S. H. Choi, J. M. Lee, N. C. Yu, K.-S. Suh, J.-J. Jang, S. H. Kim, and B. I. Choi Hepatocellular Carcinoma in Liver Transplantation Candidates: Detection with Gadobenate Dimeglumine-Enhanced MRI Am. J. Roentgenol., August 1, 2008; 191(2): 529 - 536. [Abstract] [Full Text] [PDF]

				R. F. Hanna, D. A. Aguirre, N. Kased, S. C. Emery, M. R. Peterson, and C. B. Sirlin Cirrhosis-associated Hepatocellular Nodules: Correlation of Histopathologic and MR Imaging Features RadioGraphics, May 1, 2008; 28(3): 747 - 769. [Abstract] [Full Text] [PDF]

				A. M. Lutz, J. K. Willmann, K. Goepfert, B. Marincek, and D. Weishaupt Hepatocellular Carcinoma in Cirrhosis: Enhancement Patterns at Dynamic Gadolinium- and Superparamagnetic Iron Oxide-enhanced T1-weighted MR Imaging Radiology, November 1, 2005; 237(2): 520 - 528. [Abstract] [Full Text] [PDF]

				C. Karadi, C. F. Beaulieu, R. B. Jeffrey Jr, D. S. Paik, and S. Napel Display Modes for CT Colonography: Part I. Synthesis and Insertion of Polyps into Patient CT Data Radiology, July 1, 1999; 212(1): 195 - 201. [Abstract] [Full Text]

				C. F. Beaulieu, R. B. Jeffrey Jr, C. Karadi, D. S. Paik, and S. Napel Display Modes for CT Colonography: Part II. Blinded Comparison of Axial CT and Virtual Endoscopic and Panoramic Endoscopic Volume-rendered Studies Radiology, July 1, 1999; 212(1): 203 - 212. [Abstract] [Full Text]

				Y. Itai, T. J. Vogl, and A. Stupavsky Capsule of Hepatocellular Carcinoma: Where and How Does the Capsule Show Enhancement? • Drs Vogl and Stupavsky respond: Radiology, February 1, 1999; 210(2): 577 - 579. [Full Text]

				L. Grazioli, G. Morana, M. P. Federle, G. Brancatelli, M. Testoni, M. A. Kirchin, K. Menni, L. Olivetti, N. Nicoli, and C. Procacci Focal Nodular Hyperplasia: Morphologic and Functional Information from MR Imaging with Gadobenate Dimeglumine Radiology, December 1, 2001; 221(3): 731 - 739. [Abstract] [Full Text] [PDF]

				D. Pauleit, J. Textor, R. Bachmann, R. Conrad, S. Flacke, G. Layer, B. Kreft, and H. Schild Hepatocellular Carcinoma: Detection with Gadolinium- and Ferumoxides-enhanced MR Imaging of the Liver Radiology, January 1, 2002; 222(1): 73 - 80. [Abstract] [Full Text] [PDF]