Radiology, Vol 205, 757-765, Copyright © 1997 by Radiological Society of North America

ARTICLES

Normalizing fractional moving blood volume estimates with power Doppler US: defining a stable intravascular point with the cumulative power distribution function

JM Rubin, RO Bude, JB Fowlkes, RS Spratt, PL Carson and RS Adler
Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109, USA.

PURPOSE: To normalize the power Doppler ultrasound (US) signal to the expected signal from 100% blood in the calculation of a fractional moving blood volume estimate. MATERIALS AND METHODS: To locate the signal from flowing blood with a consistent backscatter coefficient, the authors estimated the knee of the cumulative Doppler power distribution function. They used a flow-tube phantom to test the use of this knee to locate a radial position that would fall into a region of high shear stress and minimal rouleaux formation. They also studied how well the method normalized fractional moving blood volume estimates of the right renal cortex in a volunteer when simulating different body habitus and in a group of six healthy volunteers to estimate variability. RESULTS: Over five flow velocities and over undersaturated to severely oversaturated receiver gains, the calculated flow-tube area was a mean 89% +/- 7 (+/- standard deviation) of a standard. In humans, the technique normalized the fractional moving blood volume estimates over an 8-dB receiver gain variation; the mean +/- standard deviation of fractional moving blood volume estimates for the six volunteers was 37.6% +/- 3.6. CONCLUSION: Vascularity estimates with power Doppler US are feasible with a normalization scheme based on the cumulative Doppler power distribution function.

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