| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Radiology, Vol 206, 237-243, Copyright © 1998 by Radiological Society of North America
ARTICLES |
DF Kallmes, MK Borland, HJ Cloft, TA Altes, JE Dion, ME Jensen, GR Hankins and GA Helm
Department of Radiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
PURPOSE: To evaluate the growth and adhesion characteristics in vitro of genetically modified, basic fibroblast growth factor-producing fibroblasts on platinum detachable coils. MATERIALS AND METHODS: Coils of two sizes were coated with laminin, poly-L-lysine, fibronectin, and type I and type IV collagen and were cultured with basic fibroblast growth factor-secreting fibroblasts. Type I collagen strands were inserted in the lumen of some coils. Cellular proliferation and adherence during passage of coils through microcatheters were studied with both light and scanning electron microscopy. Growth factor concentration in the culture medium was measured. RESULTS: Rapid cellular proliferation was noted on all coated coils except those coated with type IV collagen. Proliferation on uncoated coils was slightly slower than on most coated coils, although confluent cell layers were present on uncoated larger-diameter coils within 48 hours. Cells had a marked propensity to grow between the primary coil windings into the coil lumen, except in coils that contained collagen filaments. Passage through microcatheters caused widespread stripping of cells from the outer surface of coils, especially the uncoated samples. Viable cells remained in the coil lumen. Supernatant contained high concentrations of growth factor. CONCLUSION: Platinum embolic coils are a promising mechanism of cell delivery for stimulation of scar formation or other desirable biologic effects.
This article has been cited by other articles:
|
|
 |
|
  D. Dai, Y.H. Ding, M.A. Danielson, R. Kadirvel, G.A. Helm, D.A. Lewis, H.J. Cloft, and D.F. Kallmes Endovascular Treatment of Experimental Aneurysms with Use of Fibroblast Transfected with Replication-Deficient Adenovirus Containing Bone Morphogenetic Protein-13 Gene AJNR Am. J. Neuroradiol., April 1, 2008; 29(4): 739 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Abruzzo, T. Tun, and A. Sambanis Efficient Transmicrocatheter Delivery of Functional Fibroblasts with a Bioengineered Collagen Gel-Platinum Microcoil Complex: Toward the Development of Endovascular Cell Therapy for Cerebral Aneurysms AJNR Am. J. Neuroradiol., September 1, 2007; 28(8): 1586 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Dai, Y. H. Ding, M. A. Danielson, R. Kadirvel, L. W. Hunter, W.-Z. Zhan, G. A. Helm, D. A. Lewis, H. J. Cloft, G. C. Sieck, et al. Endovascular Treatment of Experimental Aneurysms by Use of Fibroblast-Coated Platinum Coils: An Angiographic and Histopathologic Study Stroke, January 1, 2007; 38(1): 170 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pierot, A. Bonafe, S. Bracard, X. Leclerc, and for the French Matrix Registry Investigators Endovascular treatment of intracranial aneurysms with matrix detachable coils: immediate posttreatment results from a prospective multicenter registry. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1693 - 1699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dai, Y. H. Ding, M. A. Danielson, R. Kadirvel, D. A. Lewis, H. J. Cloft, and D. F. Kallmes Histopathologic and Immunohistochemical Comparison of Human, Rabbit, and Swine Aneurysms Embolized with Platinum Coils AJNR Am. J. Neuroradiol., November 1, 2005; 26(10): 2560 - 2568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Linfante, N. M. Akkawi, A. Perlow, V. Andreone, and A. K. Wakhloo Polyglycolide/Polylactide-Coated Platinum Coils for Patients With Ruptured and Unruptured Cerebral Aneurysms: A Single-Center Experience Stroke, September 1, 2005; 36(9): 1948 - 1953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Gonzalez, A. B. Patel, Y. Murayama, and F. Vinuela Angiographic Evidence of Aneurysm Neck Healing Following Endovascular Treatment with Bioactive Coils AJNR Am. J. Neuroradiol., April 1, 2005; 26(4): 912 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murayama, S. Tateshima, N. R. Gonzalez, and F. Vinuela Matrix and Bioabsorbable Polymeric Coils Accelerate Healing of Intracranial Aneurysms: Long-Term Experimental Study Stroke, August 1, 2003; 34(8): 2031 - 2037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Kallmes, N. H. Fujiwara, D. Yuen, D. Dai, and S.-T. Li A Collagen-Based Coil for Embolization of Saccular Aneurysms in a New Zealand White Rabbit Model AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 591 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Abrahams, C. Song, S. DeFelice, M. S. Grady, S. L. Diamond, and R. J. Levy Endovascular Microcoil Gene Delivery Using Immobilized Anti-adenovirus Antibody for Vector Tethering Stroke, May 1, 2002; 33(5): 1376 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Abruzzo, H. J. Cloft, M. Marek, G. G. Shengelaia, P. B. Snowhill, S. M. Waldrop, and A. Sambanis Interaction of Vascular Smooth Muscle Cells with Collagen-Impregnated Embolization Coils Studied with a Novel Quantitative in Vitro Model AJNR Am. J. Neuroradiol., April 1, 2002; 23(4): 674 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murayama, F. Vinuela, S. Tateshima, N. R. Gonzalez, J. K. Song, H. Mahdavieh, and L. Iruela-Arispe Cellular Responses of Bioabsorbable Polymeric Material and Guglielmi Detachable Coil in Experimental Aneurysms Stroke, April 1, 2002; 33(4): 1120 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Abrahams, M. S. Forman, M. Sean Grady, and S. L. Diamond Delivery of Human Vascular Endothelial Growth Factor with Platinum Coils Enhances Wall Thickening and Coil Impregnation in a Rat Aneurysm Model AJNR Am. J. Neuroradiol., August 1, 2001; 22(7): 1410 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Marx, H. J. Cloft, G. A. Helm, J. G. Short, H. M. Do, M. E. Jensen, and D. F. Kallmes Endovascular Treatment of Experimental Aneurysms by Use of Biologically Modified Embolic Devices: Coil-mediated Intraaneurysmal Delivery of Fibroblast Tissue Allografts AJNR Am. J. Neuroradiol., February 1, 2001; 22(2): 323 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Altes, H. J. Cloft, J. G. Short, A. DeGast, H. M. Do, G. A. Helm, and D. F. Kallmes Creation of Saccular Aneurysms in the Rabbit: A Model Suitable for Testing Endovascular Devices Am. J. Roentgenol., February 1, 2000; 174(2): 349 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murayama, Y. Suzuki, F. Viñuela, M. Kaibara, K. Kurotobi, M. Iwaki, and T. Abe Development of a Biologically Active Guglielmi Detachable Coil for the Treatment of Cerebral Aneurysms. Part I: In Vitro Study AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1986 - 1991. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Murayama, F. Viñuela, Y. Suzuki, Y. Akiba, A. Ulihoa, G. R. Duckwiler, Y. P. Gobin, H. V. Vinters, M. Iwaki, and T. Abe Development of the Biologically Active Guglielmi Detachable Coil for the Treatment of Cerebral Aneurysms. Part II: An Experimental Study in a Swine Aneurysm Model AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1992 - 1999. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. F. Kallmes, G. A. Helm, S. B. Hudson, T. A. Altes, H. M. Do, J. W. Mandell, and H. J. Cloft Histologic Evaluation of Platinum Coil Embolization in an Aneurysm Model in Rabbits Radiology, October 1, 1999; 213(1): 217 - 222. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| RADIOLOGY | RADIOGRAPHICS | RSNA JOURNALS ONLINE |
