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Radiology, Vol 209, 803-806, Copyright © 1998 by Radiological Society of North America


ARTICLES

Partial splenic embolization in five children with hypersplenism: effects of reduced-volume embolization on efficacy and morbidity

RK Harned 2nd, HR Thompson, DA Kumpe, MR Narkewicz and RJ Sokol
Department of Radiology, University of Colorado Health Sciences Center, Denver, USA.

PURPOSE: To evaluate the effects of reducing the volume of spleen infarcted during partial splenic embolization (PSE) for treatment of hypersplenism in children. MATERIALS AND METHODS: Five children with hypersplenism underwent embolization of 30%-40% of the splenic volume. The results were compared with those of a previous study of 70%-80% PSE performed in 17 children. RESULTS: The hospital stay after the procedure was reduced from 16.0 days +/- 8.0 to 6.6 days +/- 5.6. The febrile period decreased from 15.0 days +/- 8.1 to 5.0 days +/- 6.6. The peak white blood cell count was 8,300/mm3 +/- 4,600 (8.3 x 10(9)/L +/- 4.6) versus 19,400/mm3 +/- 7,800 (19.4 x 10(9)/L +/- 7.8) in the earlier study. The peak platelet count was 153,000/mm3 +/- 65,000 (153 x 10(9)/L +/- 65) versus 636,000/mm3 +/- 406,000 (636 x 10(9)/L +/- 406). The platelet count after a mean follow-up of 14 months was 70,000/mm3 +/- 7,000 (70 x 10(9)/L +/- 7) versus 230,000/mm3 +/- 62,000 (230 x 10(9)/L +/- 62) after a mean follow-up of 45 months. The frequency of variceal hemorrhage decreased from 3.5 to 0.5 episodes per year. The frequency of epistaxis decreased from 30 to 15 episodes per month. CONCLUSION: Reduced-volume embolization decreased morbidity. All patients maintained a platelet count above baseline, and no patient required repeat embolization.


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D. C. Madoff, A. Denys, M. J. Wallace, R. Murthy, S. Gupta, E. P. Pillsbury, K. Ahrar, B. Bessoud, and M. E. Hicks
Splenic Arterial Interventions: Anatomy, Indications, Technical Considerations, and Potential Complications
RadioGraphics, October 1, 2005; 25(suppl_1): S191 - S211.
[Abstract] [Full Text] [PDF]




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