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(Radiology. 1999;210:769-774.)
© RSNA, 1999

Neuroradiology

Differences between Relapsing-Remitting and Chronic Progressive Multiple Sclerosis as Determined with Quantitative MR Imaging

Yukio Miki, MD, PhD1,3, Robert I. Grossman, MD1, Jayaram K. Udupa, PhD1, Mark A. van Buchem, MD, PhD1,4, Luogang Wei, MS1, Michael D. Phillips, MD1,5, Upen Patel, MD1, Joseph C. McGowan, PhD1 and Dennis L. Kolson, MD, PhD2

1 Departments of Radiology (Y.M., R.I.G., J.K.U., M.A.v.B., L.W., M.D.P., U.P., J.C.M.)
2 Neurology (D.L.K.), University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104-4283
3 Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Hospital, Japan (Y.M.)
4 Department of Diagnostic Radiology and Nuclear Medicine, Leiden University Hospital, the Netherlands (M.A.v.B.)
5 Department of Radiology, Indiana University Medical Center, Indianapolis (M.D.P.).

PURPOSE: To investigate the cross-sectional relationships among multiple quantitative brain magnetic resonance (MR) imaging measurements in patients with relapsing-remitting versus chronic progressive multiple sclerosis (MS).

MATERIALS AND METHODS: Thirty-eight patients with MS (relapsing-remitting, 26; chronic progressive, 12) were examined. Lesion volume on T2-weighted MR images, contrast material–enhancing lesion volume, percentage of brain parenchymal volume (brain volume/[brain volume + cerebrospinal fluid volume]), and magnetization transfer ratio histogram peak height for the whole brain were calculated.

RESULTS: Significant negative correlation was noted between volume on T2-weighted images and magnetization transfer ratio histogram peak height for both the relapsing-remitting and chronic progressive groups (P < .001 for both). A positive correlation was demonstrated for lesion volume on T2-weighted images and enhancing lesion volume in the relapsing-remitting group (P < .01) but not in the chronic progressive group. Negative correlations were demonstrated for enhancing lesion volume and magnetization transfer ratio histogram peak height (P = .02), for Expanded Disability Status Scale score and magnetization transfer histogram peak height (P = .02), and for Expanded Disability Status Scale score and percentage of brain parenchymal volume in the relapsing-remitting group (P = .004) but not in the chronic progressive group.

CONCLUSION: The cross-sectional relationships among multiple quantitative brain MR imaging measurements are different between relapsing-remitting and chronic progressive MS.

Index terms: Brain, MR, 10.12143 • Brain, white matter, 10.871 • Magnetic resonance (MR), magnetization transfer contrast, 10.121417 • Sclerosis, multiple, 10.871




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