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MR Colonography: Optimized Enema Composition¹

¹ From the Institute of Diagnostic Radiology, University Hospital Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland. Received May 27, 1998; revision requested August 5; revision received September 10; accepted December 16. Supported in part by German Research Foundation stipend Lu 687/1-1. Address reprint requests to J.F.D. (e-mail: debatin@drnr.usz.ch).

Manganese chloride, iron glycerophosphate, and cellulose additive were assessed as base materials for use in a T1-shortening single contrast enema for magnetic resonance (MR) colonography. Contrast-to-noise ratios (CNRs) were compared to those with the standard 10 mmol/L gadolinium–based enema. On T1-weighted three-dimensional gradient-recalled-echo images, CNRs with the iron glycerophosphate enema exceeded those with the manganese- and gadolinium-based enemas. Use of an additive of 0.8% wt/wt cellulose was found to be practicable as it increased viscosity sufficiently without altering CNR. The gadolinium-based enema can be replaced with an iron glycerophosphate enema to render MR colonography less costly.

Index terms: Colon, MR, 75.121412, 75.121419, 75.12143 • Gadolinium • Iron • Magnetic resonance (MR), contrast agents, 75.121412, 75.121419, 75.12143 • Magnetic resonance (MR), contrast enhancement, 75.12143 • Manganese

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