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(Radiology. 1999;212:79-87.)
© RSNA, 1999

Experimental Studies

Stenosis of the Main Artery Supplying an Organ: Effect of End-Organ Vascular Resistance on the Poststenotic Peak Systolic Velocity in an in Vitro Hydraulic Model at Doppler US1

Ronald O. Bude, MD, Ronald G. Larson, PhD, Wilmer W. Nichols, PhD and Jonathan M. Rubin, MD, PhD

1 From the Department of Radiology, TC 2910K, University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0326 (R.O.B., J.M.R.); the Department of Chemical Engineering, University of Michigan, Ann Arbor (R.G.L.); and the Division of Cardiology, Department of Medicine, University of Florida, College of Medicine, Gainesville (W.W.N.). Received June 3, 1998; revision requested July 15; revision received August 25; accepted November 25. Address reprint requests to R.O.B. (e-mail: ronbude@umich.edu).

PURPOSE: To test the hypothesis that increased end-organ vascular resistance reduces blood flow to the kidney, thus reducing the mean velocity in the renal artery and secondarily lowering the peak systolic velocity (PSV).

MATERIALS AND METHODS: An in vitro hydraulic model with a pulsatile pump, blood-mimicking fluid, interchangeable stenoses, and variable compliance and resistance was used to investigate the relationship between end-organ vascular resistance and poststenotic PSV.

RESULTS: Poststenotic PSV was mildly dependent on end-organ vascular resistance and decreased with increasing resistance.

CONCLUSION: The results help explain some of the reported variability from using poststenotic PSV to detect hemodynamically significant renal arterial stenoses, but the effect is not great enough to completely explain the variability. Other factors not investigated in this study must be at work as well.

Index terms: Blood, flow dynamics, 961.72 • Renal arteries, flow dynamics, 961.72 • Renal arteries, stenosis or obstruction, 961.72 • Renal arteries, US, 961.12983, 961.12984 • Test objects, 961.12983, 961.12984, 961.72