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(Radiology. 1999;212:97-102.)
© RSNA, 1999

Experimental Studies

Contrast Medium–induced Pulmonary Edema Is Aggravated by Silicone Contamination in Rats1

Toshiaki Sendo, PhD, Masaaki Hirakawa, BS, Kaori Fujie, MS, Yasufumi Kataoka, PhD and Ryozo Oishi, PhD

1 From the Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Received May 15, 1998; revision requested July 14; revision received October 26; accepted February 12, 1999. Address reprint requests to R.O.

PURPOSE: To examine the effect of silicone contamination, which occurs in clinical settings during vial preparation with disposable syringes, on contrast medium–induced pulmonary edema in rats.

MATERIALS AND METHODS: Ioxaglate, ioversol, and iohexol, silicone-containing physiologic saline solutions, and three silicone-containing contrast media were separately, intravenously injected at 1.5 mL/min in rats. Pulmonary edema was evaluated as changes in the relative lung weight and in the water, sodium, and potassium contents of the lung.

RESULTS: Intravenous injection of ioxaglate induced marked pulmonary edema, even with a dose of only 4 g of iodine per kilogram of body weight. In contrast, ioversol and iohexol induced significant pulmonary edema only after the injection of large doses (6 g of iodine per kilogram; P < .05). The injection of 4 µL/mL silicone-containing physiologic saline at a dose of 18.75 mL/kg also produced marked pulmonary edema, whereas doses of 6.25 and 12.5 mL/kg showed no significant influence. The addition of an ineffective dose (12.5 mL of physiologic saline per kilogram of body weight) of silicone in contrast medium substantially aggravated the pulmonary edema induced by the contrast medium alone; this phenomenon was also confirmed with morphologic observation.

CONCLUSION: Ionic contrast media are more toxic to the endothelial cells than are nonionic contrast media. Silicone contamination might be one of the causes of pulmonary edema after intravenous injection. However, caution must be exercised in extrapolating these results to humans.

Index terms: Animals • Contrast media, complications, 60.46, 60.711 • Contrast media, experimental studies, 60.46, 60.711 • Lungs, fluid, 60.46, 60.711 • Silicone, 60.46






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