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(Radiology. 1999;212:567-572.)
© RSNA, 1999


Thoracic Imaging

Lymphocytic Interstitial Pneumonia: Thin-Section CT Findings in 22 Patients1

Takeshi Johkoh, MD, Nestor L. Müller, MD, PhD, Heather A. Pickford, MD, Thomas E. Hartman, MD, Kazuya Ichikado, MD, Masanori Akira, MD, Osamu Honda, MD and Hironobu Nakamura, MD

1 From the Department of Radiology, Vancouver Hospital and Health Sciences Center and University of British Columbia, 855 W 12th Ave, Vancouver, British Columbia, Canada V5Z 1M9 (T.J., N.L.M.); the Department of Radiology, Osaka University Medical School, Japan (T.J., O.H., H.N.); the Department of Radiology, Mayo Clinic, Rochester, Minn (H.A.P., T.E.H.); the First Department of Internal Medicine, Kumamoto University School of Medicine, Japan (K.I.); and the Department of Radiology, National Kinki Chuo Hospital for Chest Disease, Osaka, Japan (M.A.). Received March 25, 1998; revision requested June 18; final revision received October 23; accepted February 12, 1999. Address reprint requests to N.L.M.

PURPOSE: To assess the thin-section computed tomographic (CT) findings of lymphocytic interstitial pneumonia.

MATERIALS AND METHODS: The study included 22 patients (five men, 17 women; age range, 24–83 years; mean age, 50 years) with biopsy-proved lymphocytic interstitial pneumonia. The CT scans were obtained by using 1–3-mm collimation and reconstructed by using a high-spatial-frequency algorithm.

RESULTS: The predominant abnormalities consisted of areas of ground-glass attenuation and poorly defined centrilobular nodules present in all 22 patients and subpleural small nodules seen in 19 patients. Other common findings included thickening of bronchovascular bundles (n = 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement (n = 15). Less common findings included large nodules, emphysema, airspace consolidation, bronchiectasis, architectural distortion, honeycombing, and pleural thickening.

CONCLUSION: Lymphocytic interstitial pneumonia is characterized by the presence of ground-glass attenuation, poorly defined centrilobular nodules, and thickening of the interstitium along the lymphatic vessels. Lymph node enlargement is more common than previously recognized; it was seen in 68% of patients.

Index terms: Acquired immunodeficiency syndrome (AIDS), 60.206, 60.2068, 60.2518 • Castleman disease, 60.314, 60.391 • Eye, diseases, 22.696 • Lung, CT, 60.12112, 60.12118 • Pneumonitis, lymphocytic interstitial, 60.795 • Sjögren syndrome, 22.696, 60.795




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