HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yao, L. Articles by Eilber, F. R. Search for Related Content PubMed PubMed Citation Articles by Yao, L. Articles by Eilber, F. R.

Primary Musculoskeletal Neoplasms: Effectiveness of Core-Needle Biopsy¹

¹ From the Department of Radiology, Georgetown University Medical Center, MRI, 2nd Fl, CCC Bldg, 3800 Reservoir Rd, NW, Washington, DC 20007 (L.Y.) and the Departments of Pathology (S.D.N.), Radiological Sciences (L.L.S.), Orthopaedic Surgery (J.J.E.), and General Surgery (F.R.E.), UCLA Center for the Health Sciences University of California, Los Angeles. Received October 15, 1998; revision requested November 11; revision received December 15; accepted April 22, 1999. Address reprint requests to L.Y. (e-mail: yaol@gunet.georgetown.edu).

PURPOSE: To analyze the effectiveness of core-needle biopsy for evaluation of possible primary musculoskeletal neoplasms, which often are evaluated with open biopsy.

MATERIALS AND METHODS: Core-needle biopsy was performed at a tertiary care institution in 141 patients suspected of having a mesenchymal neoplasm. In 85 patients, the lesion was in soft tissue; in 56 patients, the lesion was in bone. Eighty-nine patients had a malignant lesion, and 52 had a benign lesion. Twenty-eight patients had undergone previous surgery.

RESULTS: In 105 (74%) patients, core-needle biopsy results were concordant with results from specimens subsequently obtained at surgery with respect to tumor histologic features and grade, or they provided sufficient diagnostic information to obviate surgery. In 36 (26%) patients, inaccurate core-needle biopsy results were obtained: In nine, results were imprecise about exact histologic features; in three, results were correct about histologic features but incorrect about tumor grade. In 25 (18%) patients, open biopsy was performed after core-needle biopsy. The accuracy and rate of performance of open biopsy for soft-tissue lesions were not significantly different from those for bone lesions.

CONCLUSION: Percutaneous core-needle biopsy can be an effective alternative to open biopsy in the evaluation of possible mesenchymal neoplasms of either bone or soft tissue. Needle biopsy of such lesions, however, is best performed as part of a multidisciplinary team approach to tumor management.

Index terms: Biopsies, _**.1261² • Desmoid, 49.3132 • Lipoma and lipomatosis, _**.31² • Liposarcoma, 40.371 • Lung neoplasms, 60.31, 60.32, 60.33 • Lymphoma, 60.34

This article has been cited by other articles:

				J. S. Wu, J. D. Goldsmith, P. J. Horwich, S. K. Shetty, and M. G. Hochman Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy? Radiology, September 1, 2008; 248(3): 962 - 970. [Abstract] [Full Text] [PDF]

				A. Nourbakhsh, J. J. Grady, and K. J. Garges Percutaneous Spine Biopsy: A Meta-Analysis J. Bone Joint Surg. Am., August 1, 2008; 90(8): 1722 - 1725. [Abstract] [Full Text] [PDF]

				J. A. Carrino, B. Khurana, J. E. Ready, S. G. Silverman, and C. S. Winalski Magnetic Resonance Imaging-Guided Percutaneous Biopsy of Musculoskeletal Lesions J. Bone Joint Surg. Am., October 1, 2007; 89(10): 2179 - 2187. [Abstract] [Full Text] [PDF]

				P. T. Liu, S. D. Valadez, F. S. Chivers, C. C. Roberts, and C. P. Beauchamp Anatomically Based Guidelines for Core Needle Biopsy of Bone Tumors: Implications for Limb-sparing Surgery RadioGraphics, January 1, 2007; 27(1): 189 - 205. [Abstract] [Full Text] [PDF]

				M. Soudack, A. Nachtigal, E. Vladovski, O. Brook, and D. Gaitini Sonographically Guided Percutaneous Needle Biopsy of Soft Tissue Masses With Histopathologic Correlation. J. Ultrasound Med., October 1, 2006; 25(10): 1271 - 1277. [Abstract] [Full Text] [PDF]

				P. Petrow, C. Dromain, J. M. Guinebretiere, and D. Vanel Normal Intratumoral Lymph Node in a Patient with Lipoma Mimicking Liposarcoma Am. J. Roentgenol., August 1, 2003; 181(2): 569 - 570. [Full Text] [PDF]

				J. S. Jelinek, M. D. Murphey, J. A. Welker, R. M. Henshaw, M. J. Kransdorf, B. M. Shmookler, and M. M. Malawer Diagnosis of Primary Bone Tumors with Image-guided Percutaneous Biopsy: Experience with 110 Tumors Radiology, June 1, 2002; 223(3): 731 - 737. [Abstract] [Full Text] [PDF]

				G. Bodner, M. F. H. Schocke, F. Rachbauer, K. Seppi, S. Peer, A. Fierlinger, T. Sununu, and W. R. Jaschke Differentiation of Malignant and Benign Musculoskeletal Tumors: Combined Color and Power Doppler US and Spectral Wave Analysis Radiology, May 1, 2002; 223(2): 410 - 416. [Abstract] [Full Text] [PDF]

				M. Torriani, M. Etchebehere, and E. M. I. Amstalden Sonographically Guided Core Needle Biopsy of Bone and Soft Tissue Tumors J. Ultrasound Med., March 1, 2002; 21(3): 275 - 281. [Abstract] [Full Text] [PDF]