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Simultaneous Noninvasive Determination of Regional Myocardial Perfusion and Oxygen Content in Rabbits: Toward Direct Measurement of Myocardial Oxygen Consumption at MR Imaging¹

¹ From the Departments of Biomedical Engineering (S.B.R., A.A.H., E.R.M.) and Radiology (E.R.M., J.R.F.), Johns Hopkins University School of Medicine, Baltimore, Md. Received September 12, 1997; revision requested November 24; final revision received December 12, 1998; accepted February 15, 1999. J.R.F. is supported by a grant from the Whitaker Foundation. S.B.R. is supported by a Medical Scientist Training Program Fellowship. Address reprint requests to J.R.F., Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, CMRL Bldg, 828 8th Ct S, Birmingham, AL 35294-4470.

PURPOSE: To determine whether myocardial arterial perfusion and oxygen concentration can be quantified simultaneously from the same images by using spin labeling and the blood oxygenation level–dependent (BOLD) effect with fast spin-echo (SE) imaging.

MATERIALS AND METHODS: A T2-weighted fast SE pulse sequence was written to image isolated, arrested, blood-perfused rabbit hearts (n = 6) at 4.7 T. Perfusion images with intensity in units of milliliters per minute per gram that covered the entire left ventricle with 0.39 x 0.39 x 3.00-mm resolution were obtained in less than 15 minutes with a 32-fold reduction in imaging time from that of a previous study. Estimates of oxygen concentration were made from the same images acquired for calculation of perfusion images.

RESULTS: Estimates of regional myocardial oxygen content could be made from the perfusion images; this demonstrated the feasibility of three-dimensional calculation of regional oxygen consumption, which requires concomitant measurement of both oxygen content and flow. Fast SE imaging was shown to be as sensitive to hemoglobin desaturation as standard SE imaging. Perfusion abnormalities and oxygen deficits were easily identified and verified qualitatively with gadopentetate dimeglumine on both perfusion and BOLD images obtained after coronary arterial ligation.

CONCLUSION: T2-weighted fast SE imaging combined with perfusion-sensitive spin labeling can be used to measure myocardial arterial perfusion and oxygen concentration. This provides the groundwork for calculation of regional myocardial oxygen consumption.

Index terms: Animals • Heart, MR, 511.121411, 511.91 • Magnetic resonance (MR), experimental studies, 511.121411 • Magnetic resonance (MR), perfusion study, 511.121411 • Magnetic resonance (MR), technology, 511.121411 • Myocardium, blood supply, 511.91

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