| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Nuclear Medicine |
1 From the Departments of Radiology (E.M.M., H.P.M., J.J.E., P.C.G., R.E.C., E.F.P.) and Medicine (J.E.H.), Duke University Medical Center, Box 3808, Durham, NC 27710; and the Department of Radiology, Veterans Affairs Medical Center, Durham, NC (D.K.C.). Received July 27, 1998; revision requested September 24; final revision received December 9; accepted March 29, 1999. Address reprint requests to E.F.P.
PURPOSE: To compare the accuracies of whole-body 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) and conventional imaging (thoracic computed tomography [CT], bone scintigraphy, and brain CT or magnetic resonance [MR] imaging) in staging bronchogenic carcinoma.
MATERIALS AND METHODS: Within 20 months, 100 patients with newly diagnosed bronchogenic carcinoma underwent whole-body FDG PET and chest CT. Ninety of these patients underwent radionuclide bone scintigraphy, and 70 patients underwent brain CT or MR imaging. For each patient, all examinations were completed within 1 month. A radiologic stage was assigned by using PET and conventional imaging independently and was compared with the pathologic stage. The accuracy, sensitivity, specificity, and negative and positive predictive values were calculated.
RESULTS: PET staging was accurate in 83 (83%) patients; conventional imaging staging was accurate in 65 (65%) patients (P < .005). Staging with mediastinal lymph nodes was correct by using PET in 67 (85%) patients and by using CT in 46 (58%) patients (P < .001). Nine (9%) patients had metastases demonstrated by using PET that were not found with conventional imaging, whereas 10 (10%) patients suspected of having metastases because of conventional imaging findings were correctly shown with PET to not have metastases.
CONCLUSION: Whole-body PET was more accurate than thoracic CT, bone scintigraphy, and brain CT or MR imaging in staging bronchogenic carcinoma.
Index terms: Bronchi, neoplasms, 60.3211, 60.3212, 60.3214, 60.3216, 60.3217 • Lung neoplasms, emission CT (ECT), 60.12163 • Lung neoplasms, staging, 60.3211, 60.3212, 60.3214, 60.3216, 60.3217
This article has been cited by other articles:
|
|
 |
|
  W. De Wever, S. Stroobants, J. Coolen, and J. A. Verschakelen Integrated PET/CT in the staging of nonsmall cell lung cancer: technical aspects and clinical integration Eur. Respir. J., January 1, 2009; 33(1): 201 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Patz Jr Does Computed Tomography or Positron Emission Tomography Response After Neoadjuvant Chemotherapy for Resectable Non-Small-Cell Lung Cancer Predict Survival? J. Clin. Oncol., October 1, 2008; 26(28): 4542 - 4543. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Uesaka, Y. Demura, T. Ishizaki, S. Ameshima, I. Miyamori, M. Sasaki, Y. Fujibayashi, and H. Okazawa Evaluation of Dual-Time-Point 18F-FDG PET for Staging in Patients with Lung Cancer J. Nucl. Med., October 1, 2008; 49(10): 1606 - 1612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A Yi, K. M. Shin, K. S. Lee, B.-T. Kim, H. Kim, O J. Kwon, J. Y. Choi, and M. J. Chung Non-Small Cell Lung Cancer Staging: Efficacy Comparison of Integrated PET/CT versus 3.0-T Whole-Body MR Imaging Radiology, August 1, 2008; 248(2): 632 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Molina, P. Yang, S. D. Cassivi, S. E. Schild, and A. A. Adjei Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship Mayo Clin. Proc., May 1, 2008; 83(5): 584 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Hoang, L. F. Hoagland, R. E. Coleman, A. D. Coan, J. E. Herndon II, and E. F. Patz Jr Prognostic Value of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography Imaging in Patients With Advanced-Stage Non-Small-Cell Lung Carcinoma J. Clin. Oncol., March 20, 2008; 26(9): 1459 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. C. Ung, D. E. Maziak, J. A. Vanderveen, C. A. Smith, K. Gulenchyn, C. Lacchetti, W. K. Evans, and Lung Cancer Disease Site Group of Cancer Care Onta 18Fluorodeoxyglucose Positron Emission Tomography in the Diagnosis and Staging of Lung Cancer: A Systematic Review J Natl Cancer Inst, December 5, 2007; 99(23): 1753 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hellwig, T. P. Graeter, D. Ukena, A. Groeschel, G. W. Sybrecht, H.-J. Schaefers, and C.-M. Kirsch 18F-FDG PET for Mediastinal Staging of Lung Cancer: Which SUV Threshold Makes Sense? J. Nucl. Med., November 1, 2007; 48(11): 1761 - 1766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Silvestri, M. K. Gould, M. L. Margolis, L. T. Tanoue, D. McCrory, E. Toloza, and F. Detterbeck Noninvasive Staging of Non-small Cell Lung Cancer: ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition) Chest, September 1, 2007; 132(3_suppl): 178S - 201S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Singh, B. Camazine, Y. Jadhav, R. Gupta, P. Mukhopadhyay, A. Khan, R. Reddy, Q. Zheng, D. D. Smith, R. Khode, et al. Endoscopic Ultrasound As a First Test for Diagnosis and Staging of Lung Cancer: A Prospective Study Am. J. Respir. Crit. Care Med., February 15, 2007; 175(4): 345 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Posther, L. M. McCall, D. H. Harpole Jr., C. E. Reed, J. B. Putnam Jr., V. W. Rusch, and B. A. Siegel Yield of Brain 18F-FDG PET in Evaluating Patients with Potentially Operable Non-Small Cell Lung Cancer J. Nucl. Med., October 1, 2006; 47(10): 1607 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. McLoud "A system for the clinical staging of lung cancer"--a commentary. Am. J. Roentgenol., August 1, 2006; 187(2): 269 - 270. [Full Text] [PDF]
|
|
|
|
|
|
S. Shiraishi, S. Tomiguchi, D. Utsunomiya, K. Kawanaka, K. Awai, S. Morishita, T. Okuda, K. Yokotsuka, and Y. Yamashita Quantitative Analysis and Effect of Attenuation Correction on Lymph Node Staging of Non-Small Cell Lung Cancer on SPECT and CT. Am. J. Roentgenol., May 1, 2006; 186(5): 1450 - 1457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hishida, K. Nagai, J. Yoshida, M. Nishimura, G.-i. Ishii, M. Iwasaki, and Y. Nishiwaki Is surgical resection indicated for a solitary non-small cell lung cancer recurrence? J. Thorac. Cardiovasc. Surg., April 1, 2006; 131(4): 838 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prevost, L. Boucher, P. Larivee, R. Boileau, and F. Benard Bone Marrow Hypermetabolism on 18F-FDG PET as a Survival Prognostic Factor in Non-Small Cell Lung Cancer J. Nucl. Med., April 1, 2006; 47(4): 559 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bunyaviroch and R. E. Coleman PET Evaluation of Lung Cancer J. Nucl. Med., March 1, 2006; 47(3): 451 - 469. [Full Text] [PDF]
|
|
|
|
 |
|
 O. Birim, A. P. Kappetein, and A. J.J.C. Bogers Reply Ann. Thorac. Surg., November 1, 2005; 80(5): 1980 - 1981. [Full Text] [PDF]
|
|
|
|
|
|
D. B. Costa, J. A. Parker, and S. T. Schumer Modern Treatment of Lung Cancer: CASE 3. Non-Metastatic Bilateral F-18 Fluorodeoxyglucose Avid Adrenal Glands in Non-Small-Cell Lung Cancer J. Clin. Oncol., October 20, 2005; 23(30): 7740 - 7742. [Full Text] [PDF]
|
|
|
|
|
|
D. Lardinois, W. Weder, M. Roudas, G. K. von Schulthess, M. Tutic, H. Moch, R. A. Stahel, and H. C. Steinert Etiology of Solitary Extrapulmonary Positron Emission Tomography and Computed Tomography Findings in Patients With Lung Cancer J. Clin. Oncol., October 1, 2005; 23(28): 6846 - 6853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Onn, D. H. Choe, R. S. Herbst, A. M. Correa, R. F. Munden, M. T. Truong, A. A. Vaporciyan, T. Isobe, M. Z. Gilcrease, and E. M. Marom Tumor Cavitation in Stage I Non-Small Cell Lung Cancer: Epidermal Growth Factor Receptor Expression and Prediction of Poor Outcome Radiology, October 1, 2005; 237(1): 342 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Shim, K. S. Lee, B.-T. Kim, M. J. Chung, E. J. Lee, J. Han, J. Y. Choi, O J. Kwon, Y. M. Shim, and S. Kim Non-Small Cell Lung Cancer: Prospective Comparison of Integrated FDG PET/CT and CT Alone for Preoperative Staging Radiology, September 1, 2005; 236(3): 1011 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. K. Shankar and D. C. Sullivan Functional Imaging in Lung Cancer J. Clin. Oncol., May 10, 2005; 23(14): 3203 - 3211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Kelloff, J. M. Hoffman, B. Johnson, H. I. Scher, B. A. Siegel, E. Y. Cheng, B. D. Cheson, J. O'Shaughnessy, K. Z. Guyton, D. A. Mankoff, et al. Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development Clin. Cancer Res., April 15, 2005; 11(8): 2785 - 2808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Birim, A. P. Kappetein, T. Stijnen, and A. J.J.C. Bogers Meta-Analysis of Positron Emission Tomographic and Computed Tomographic Imaging in Detecting Mediastinal Lymph Node Metastases in Nonsmall Cell Lung Cancer Ann. Thorac. Surg., January 1, 2005; 79(1): 375 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Antoch, N. Saoudi, H. Kuehl, G. Dahmen, S. P. Mueller, T. Beyer, A. Bockisch, J. F. Debatin, and L. S. Freudenberg Accuracy of Whole-Body Dual-Modality Fluorine-18-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography and Computed Tomography (FDG-PET/CT) for Tumor Staging in Solid Tumors: Comparison With CT and PET J. Clin. Oncol., November 1, 2004; 22(21): 4357 - 4368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Schrevens, N. Lorent, C. Dooms, and J. Vansteenkiste The Role of PET Scan in Diagnosis, Staging, and Management of Non-Small Cell Lung Cancer Oncologist, November 1, 2004; 9(6): 633 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Finke, M.-C. Aubry, H. D. Tazelaar, G. L. Aughenbaugh, C. M. Lohse, V. S. Pankratz, and C. Deschamps Autopsy Results After Surgery for Non-Small Cell Lung Cancer Mayo Clin. Proc., November 1, 2004; 79(11): 1409 - 1414. [Abstract] [PDF]
|
|
|
|
 |
|
 L N Gomersall and S Olson Imaging in lung cancer Imaging, October 1, 2004; 16(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Aquino and A. J. Fischman Does Whole-Body 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Have an Advantage Over Thoracic Positron Emission Tomography for Staging Patients With Lung Cancer? Chest, September 1, 2004; 126(3): 755 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Detterbeck, S. Falen, M. P. Rivera, J. S. Halle, and M. A. Socinski Seeking a Home for a PET, Part 2: Defining the Appropriate Place for Positron Emission Tomography Imaging in the Staging of Patients With Suspected Lung Cancer Chest, June 1, 2004; 125(6): 2300 - 2308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rohren, T. G. Turkington, and R. E. Coleman Clinical Applications of PET in Oncology Radiology, May 1, 2004; 231(2): 305 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kahn, Y. Menda, K. Kernstine, D. Bushnell, K. McLaughlin, S. Miller, and K. Berbaum The Utility of 99mTc Depreotide Compared With F-18 Fluorodeoxyglucose Positron Emission Tomography and Surgical Staging in Patients With Suspected Non-small Cell Lung Cancer Chest, February 1, 2004; 125(2): 494 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Even-Sapir, U. Metser, G. Flusser, L. Zuriel, Y. Kollender, H. Lerman, G. Lievshitz, I. Ron, and E. Mishani Assessment of Malignant Skeletal Disease: Initial Experience with 18F-Fluoride PET/CT and Comparison Between 18F-Fluoride PET and 18F-Fluoride PET/CT J. Nucl. Med., February 1, 2004; 45(2): 272 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Metser, H. Lerman, A. Blank, G. Lievshitz, F. Bokstein, and E. Even-Sapir Malignant Involvement of the Spine: Assessment by 18F-FDG PET/CT J. Nucl. Med., February 1, 2004; 45(2): 279 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Pfister, D. H. Johnson, C. G. Azzoli, W. Sause, T. J. Smith, S. Baker Jr, J. Olak, D. Stover, J. R. Strawn, A. T. Turrisi, et al. American Society of Clinical Oncology Treatment of Unresectable Non-Small-Cell Lung Cancer Guideline: Update 2003 J. Clin. Oncol., January 15, 2004; 22(2): 330 - 353. [Full Text] [PDF]
|
|
|
|
|
|
G. W. Goerres, G. K. von Schulthess, and H. C. Steinert Why Most PET of Lung and Head-and-Neck Cancer Will Be PET/CT J. Nucl. Med., January 1, 2004; 45(90010): 66S - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Gould, W. G. Kuschner, C. E. Rydzak, C. C. Maclean, A. N. Demas, H. Shigemitsu, J. K. Chan, and D. K. Owens Test Performance of Positron Emission Tomography and Computed Tomography for Mediastinal Staging in Patients with Non-Small-Cell Lung Cancer: A Meta-Analysis Ann Intern Med, December 2, 2003; 139(11): 879 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Reed, D. H. Harpole, K. E. Posther, S. L. Woolson, R. J. Downey, B. F. Meyers, R. T. Heelan, H. A. MacApinlac, S.-H. Jung, G. A. Silvestri, et al. Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1943 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Antoch, J. Stattaus, A. T. Nemat, S. Marnitz, T. Beyer, H. Kuehl, A. Bockisch, J. F. Debatin, and L. S. Freudenberg Non-Small Cell Lung Cancer: Dual-Modality PET/CT in Preoperative Staging Radiology, November 1, 2003; 229(2): 526 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Buck, G. Halter, H. Schirrmeister, J. Kotzerke, I. Wurziger, G. Glatting, T. Mattfeldt, B. Neumaier, S. N. Reske, and M. Hetzel Imaging Proliferation in Lung Tumors with PET: 18F-FLT Versus 18F-FDG J. Nucl. Med., September 1, 2003; 44(9): 1426 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lardinois, W. Weder, T. F. Hany, E. M. Kamel, S. Korom, B. Seifert, G. K. von Schulthess, and H. C. Steinert Staging of Non-Small-Cell Lung Cancer with Integrated Positron-Emission Tomography and Computed Tomography N. Engl. J. Med., June 19, 2003; 348(25): 2500 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Dizendorf, B. G. Baumert, G. K. von Schulthess, U. M. Lutolf, and H. C. Steinert Impact of Whole-Body 18F-FDG PET on Staging and Managing Patients for Radiation Therapy J. Nucl. Med., January 1, 2003; 44(1): 24 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Toloza, L. Harpole, and D. C. McCrory Noninvasive Staging of Non-small Cell Lung Cancer: A Review of the Current Evidence Chest, January 1, 2003; 123(1_suppl): 137S - 146S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rohren, J. M. Provenzale, D. P. Barboriak, and R. E. Coleman Screening for Cerebral Metastases with FDG PET in Patients Undergoing Whole-Body Staging of Non-Central Nervous System Malignancy Radiology, January 1, 2003; 226(1): 181 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Spiro and J. C. Porter Lung Cancer--Where Are We Today?: Current Advances in Staging and Nonsurgical Treatment Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1166 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Dunnick and M. Korobkin Imaging of Adrenal Incidentalomas: Current Status Am. J. Roentgenol., September 1, 2002; 179(3): 559 - 568. [Full Text] [PDF]
|
|
|
|
|
|
N. Hollings and P. Shaw Diagnostic imaging of lung cancer Eur. Respir. J., April 1, 2002; 19(4): 722 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A G Pitman, R J Hicks, D S Binns, R E Ware, V Kalff, A F McKenzie, D L Ball, and M P MacManus Performance of sodium iodide based 18F-fluorodeoxyglucose positron emission tomography in the characterization of indeterminate pulmonary nodules or masses Br. J. Radiol., February 1, 2002; 75(890): 114 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.F. Vansteenkiste Imaging in lung cancer: positron emission tomography scan Eur. Respir. J., February 1, 2002; 19(35_suppl): 49S - 60s. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Laking and P Price 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) and the staging of early lung cancer Thorax, September 1, 2001; 56(90002): ii38 - 44. [Full Text] [PDF]
|
|
|
|
|
|
S. S. Gambhir, J. Czernin, J. Schwimmer, D. H. S. Silverman, R. E. Coleman, and M. E. Phelps A Tabulated Summary of the FDG PET Literature J. Nucl. Med., May 1, 2001; 42(90050): 1S - 93. [Full Text] [PDF]
|
|
|
|
|
|
J.F. Vansteenkiste and S.G. Stroobants The role of positron emission tomography with 18F-fluoro-2-deoxy-D-glucose in respiratory oncology Eur. Respir. J., April 1, 2001; 17(4): 802 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kalff, R. J. Hicks, M. P. MacManus, D. S. Binns, A. F. McKenzie, R. E. Ware, A. Hogg, and D. L. Ball Clinical Impact of 18F Fluorodeoxyglucose Positron Emission Tomography in Patients With Non-Small-Cell Lung Cancer: A Prospective Study J. Clin. Oncol., January 1, 2001; 19(1): 111 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Podoloff and E. M. Marom Non-Small Cell Lung Cancer: Staging at Whole-Body PET Dr Marom responds: Radiology, December 1, 2000; 217(3): 918 - 919. [Full Text]
|
|
|
|
 |
|
 E. F. Patz Jr 1999 Plenary Session: Friday Imaging Symposium : Evaluation of Focal Pulmonary Abnormalities with FDG PET RadioGraphics, July 1, 2000; 20(4): 1182 - 1185. [Full Text] [PDF]
|
|
