HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Giess, C. S. Articles by Rosenblatt, R. Search for Related Content PubMed PubMed Citation Articles by Giess, C. S. Articles by Rosenblatt, R.

Local Tumor Recurrence following Breast-Conservation Therapy: Correlation of Histopathologic Findings with Detection Method and Mammographic Findings¹

¹ From the Departments of Radiology (C.S.G., D.M.K., R.R.) and Surgery (M.P.O.), New York Presbyterian Hospital–Weill Medical College of Cornell University, Strang Cornell Breast Center, New York. Received June 17, 1998; revision requested August 6; final revision received November 17; accepted March 26, 1999. Address reprint requests to C.S.G., Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021.

PURPOSE: To correlate histopathologic findings with detection method and mammographic appearance in primary and locally recurrent breast carcinoma after breast-conservation therapy.

MATERIALS AND METHODS: Medical records and mammographic findings were retrospectively reviewed; 26 patients with 27 local recurrences after breast-conservation therapy were identified.

RESULTS: Primary histopathologic findings included six in situ and 20 invasive carcinomas. Of the 27 recurrences, 19 (70%) were at or adjacent to the lumpectomy site and eight (30%) were elsewhere in the breast. All primary ductal carcinoma in situ (DCIS) cases manifested mammographically as microcalcifications and recurred as DCIS with microcalcifications. Eleven primary invasive carcinomas (10 masses, one case of microcalcifications) were detected only mammographically, three were detected only with physical examination, and six (six masses) were detected with both. Among these 20 recurrences, 14 (five masses, nine cases of microcalcifications) were detected only mammographically, one was detected only with physical examination, and five (five masses) were detected with both. Seventeen (85%) of 20 primary invasive carcinomas recurred invasively: 16 (94%) with similar histopathologic findings and eight (47%) with similar mammographic findings.

CONCLUSION: In local recurrence after breast-conservation therapy for DCIS, histopathologic findings, detection method, and mammographic findings are usually similar. Histopathologic findings of primary invasive breast carcinoma and local recurrence are usually similar, but the detection method and mammographic findings vary. This is relevant to the interpretation of new clinical or mammographic findings following lumpectomy.

Index terms: Breast neoplasms, calcification, 00.4535 • Breast neoplasms, diagnosis, 00.32, 00.33 • Breast neoplasms, surgery, 00.455, 00.458 • Breast neoplasms, therapeutic radiology, 00.459

This article has been cited by other articles:

				R. W. Pinsky, M. Rebner, L. J. Pierce, M. A. Ben-David, F. Vicini, K. A. Hunt, and M. A. Helvie Recurrent Cancer After Breast-Conserving Surgery with Radiation Therapy for Ductal Carcinoma in Situ: Mammographic Features, Method of Detection, and Stage of Recurrence Am. J. Roentgenol., July 1, 2007; 189(1): 140 - 144. [Abstract] [Full Text] [PDF]

				I. Gunhan-Bilgen and A. Oktay Management of Microcalcifications Developing at the Lumpectomy Bed After Conservative Surgery and Radiation Therapy Am. J. Roentgenol., February 1, 2007; 188(2): 393 - 398. [Abstract] [Full Text] [PDF]

				S. Sadetzki, B. Oberman, D. Zipple, B. Kaufman, S. Rizel, I. Novikov, and M. Z. Papa Breast Conservation After Neoadjuvant Chemotherapy Ann. Surg. Oncol., June 1, 2005; 12(6): 480 - 487. [Abstract] [Full Text] [PDF]

				N. Morakkabati, C. C. Leutner, A. Schmiedel, H. H. Schild, and C. K. Kuhl Breast MR Imaging during or Soon after Radiation Therapy Radiology, December 1, 2003; 229(3): 893 - 901. [Abstract] [Full Text] [PDF]

				C. S. Giess, D. M. Keating, M. P. Osborne, J. Mester, and R. Rosenblatt Comparison of Rate of Development and Rate of Change for Benign and Malignant Breast Calcifications at the Lumpectomy Bed Am. J. Roentgenol., September 1, 2000; 175(3): 789 - 793. [Abstract] [Full Text] [PDF]

				P. I. Haigh, R. J. Brenner, and A. E. Giuliano Origin of Metallic Particles Resembling Microcalcifications on Mammograms after Use of Abrasive Cautery-Tip Cleaning Pads during Breast Surgery: Experimental Demonstration Radiology, August 1, 2000; 216(2): 539 - 544. [Abstract] [Full Text]