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(Radiology. 1999;212:890-895.)
© RSNA, 1999

Technical Developments

Pulmonary Perfusion: Respiratory-triggered Three-dimensional MR Imaging with Arterial Spin Tagging-Preliminary Results in Healthy Volunteers1

David A. Roberts, MD, PhD, Warren B. Gefter, MD, Joshua A. Hirsch, MD, Rahim R. Rizi, PhD, Lawrence Dougherty, PhD, Robert E. Lenkinski, PhD, John S. Leigh, Jr, PhD and Mitchell D. Schnall, MD, PhD

1 From the Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce St, Philadelphia, PA 19104-4283. Received March 5, 1998; revision requested June 5; final revision received October 27; accepted March 16, 1999. Supported in part by a seed grant from the Society for Thoracic Radiology. Address reprint requests to D.A.R. (e-mail: roberts@oasis.rad.upenn.edu).

The authors used a spin-tagging method of magnetic resonance perfusion imaging to measure pulmonary perfusion in eight healthy volunteers with use of a respiratory-triggered three-dimensional pulse sequence. The average signal intensity (SI) decrease upon arterial labeling was 24%. The perfusion SI increased by 21% after exercise (P = .02). Focal blood flow abnormalities were observed in a patient with chronic obstructive pulmonary disease.

Index terms: Lung, MR, 60.121412, 60.121417 • Lung, perfusion, 60.91 • Lung, ventilation, 60.91




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