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(Radiology. 1999;212:903-910.)
© RSNA, 1999

Technical Developments

Pulsed Magnetization Transfer Imaging: Evaluation of Technique1

Simon J. Graham, PhD and R. Mark Henkelman, PhD

1 From the Departments of Medical Biophysics (S.J.G., R.M.H.) and Medical Imaging (R.M.H.), University of Toronto, Ontario, Canada, and Imaging and Bioengineering Research, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5. Received September 10, 1998; revision requested November 3; revision received December 2; accepted March 1, 1999. Supported in part by the Terry Fox Foundation and GE Medical Systems of Canada. Address reprint requests to S.J.G. (e-mail: sgraham@sten.sunnybrook.utoronto).

With use of an established physical model, numeric simulations were performed to evaluate current imaging protocols for the two primary applications of magnetization transfer: cerebral magnetic resonance angiography and neuroimaging of white matter disease. The authors found that the current technique is appropriate in the former but suboptimal in the latter. Further clinical investigations could potentially improve magnetization protocols for neuroimaging.

Index terms: Brain, abnormalities, 10.871 • Brain, MR, 10.121417 • Brain, white matter, 10.121417 • Magnetic resonance (MR), magnetization transfer contrast, 10.121417 • Sclerosis, multiple, 10.871