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(Radiology. 1999;213:135-140.)
© RSNA, 1999

Neuroradiology

Brain Tumors: Complications of Cerebral Angiography Accompanied by Intraarterial Chemotherapy1

Miguel Gelman, MD, Donald W. Chakeres, MD and Herbert B. Newton, MD

1 From the Departments of Radiology (M.G., D.W.C.) and Neurology (H.B.N.), Ohio State University Medical Center, S-255 Rhodes Hall, 450 W 10th Ave, Columbus, OH 43210. From the 1998 RSNA scientific assembly. Received June 22, 1998; revision requested August 4; final revision received January 12, 1999; accepted March 26. Address reprint requests to D.W.C.

PURPOSE: To evaluate the rate of complications associated with diagnostic cerebral angiography accompanied by intraarterial chemotherapy for the treatment of primary and metastatic brain tumors.

MATERIALS AND METHODS: Three hundred ninety-two consecutive transfemoral cerebral angiographic procedures accompanied by intraarterial chemotherapy were performed in 48 patients (28 men, 20 women), and complications were evaluated.

RESULTS: The most common local complications were groin hematomas, which occurred in 10 (2.6%) of the 392 procedures and none of which required therapy. Two carotid arterial dissections (0.5%) were reported in two patients who were asymptomatic and did not require further treatment. Both improved at follow-up examinations. Only one patient required surgery for a delayed popliteal embolus. Systemic transient complications occurred five times (1.3%). There were seven (1.8%) transient neurologic events, which were paresis and visual disturbances. Six (1.5%) transient seizure events were recorded. There were no permanent neurologic complications.

CONCLUSION: Intraarterial chemotherapy for brain tumors is a safe procedure with a low complication rate.

Index terms: Angiography, complications, 10.124, 10.441, 10.442, 10.445 • Brain neoplasms, 10.363, 10.38 • Brain neoplasms, therapy, 10.124, 10.1266 • Chemotherapeutic infusion, 10.1266 • Chemotherapy, complications, 10.1266, 10.441, 10.442, 10.445




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