HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kishi, K. Articles by Uede, K. Search for Related Content PubMed PubMed Citation Articles by Kishi, K. Articles by Uede, K.

T1 and T2 Lip Cancer: A Superselective Method of Facial Arterial Infusion Therapy-Preliminary Experience¹

¹ From the Departments of Radiology (K.K., M. Sato, T.S.) and Dermatology (M.M., M. Sakurane, K.U.), Wakayama Medical College, Wakayama City, Japan. Received April 6, 1998; revision requested May 22; final revision received December 3; accepted March 17, 1999. Supported in part by a grant in aid for cancer therapy from the Japanese Ministry of Welfare, 1994, 1995, 1996, and 1997, as part of the Study of Clinical Evaluation of Interventional Radiology in Cancer Management. Address reprint requests to K.K., Department of Radiology, Wakayama Medical College, Kimiidera 811-1, Wakayama City, 641-0012 Japan (e-mail: SachiKishi@aol.com).

PURPOSE: To formulate and evaluate a facial arterial infusion chemotherapy for squamous cell lip carcinoma.

MATERIALS AND METHODS: The study included six patients (age range, 46–84 years) with squamous cell carcinoma of the lower lip. There were two T1 tumors, three T2 tumors, and one T1-compatible postoperative recurrent tumor. A 4-F, double-lumen balloon catheter was inserted into the external carotid artery through the superficial temporal artery and placed for selective infusion into the tumor-feeding facial artery. Patients received a combination of mitomycin C (4.4 mg/m² per body surface area) on day 1 and 3.2 mg/m² of peplomycin sulfate on days 1–7 (22.4 mg/m² per week), or, when peplomycin sulfate was contraindicated, 16 mg/m² of cisplatin only on days 1–5 (80 mg/m² per week). Two to three cycles of chemotherapy were given until tumor disappearance was histologically confirmed.

RESULTS: Complete tumor disappearance was achieved in all cases. One patient had a self-limiting asthma attack during peplomycin sulfate treatment, and another had transient partial hair loss. No disfigurement, recurrence, or late complications were observed at a mean follow-up of 5.0 years (range, 2.3–11.2 years).

CONCLUSION: The described facial arterial infusion chemotherapy appears to be a safe and curative treatment for T1 and T2 squamous cell lip carcinomas.

Index terms: Angiography, 262.124 • Catheters and catheterization, 905.1266 • Chemotherapeutic infusion, 262.1266 • Face, neoplasms, 262.373

This article has been cited by other articles:

				B. Damascelli, G. L. Patelli, R. Lanocita, G. D. Tolla, L. F. Frigerio, A. Marchiano, F. Garbagnati, C. Spreafico, V. Ticha, C. R. Gladin, et al. A Novel Intraarterial Chemotherapy Using Paclitaxel in Albumin Nanoparticles to Treat Advanced Squamous Cell Carcinoma of the Tongue: Preliminary Findings Am. J. Roentgenol., July 1, 2003; 181(1): 253 - 260. [Abstract] [Full Text] [PDF]