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Experimental Studies |
1 From the Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, L308, San Francisco, CA 94143-0628 (M.S., J.B., M.F.W., R.W., C.B.H.), and Schering, Berlin, Germany (H.J.W.). From the 1998 RSNA scientific assembly. Received August 7, 1998; revision requested October 5; revision received November 6; accepted March 29, 1999. Address reprint requests to M.S. (e-mail: Maythem .Saeed@radiology.ucsf.edu).
PURPOSE: To measure the difference in size of reperfused myocardial infarction with necrosis-specific (bis-gadolinium-mesoporphyrin [hereafter, mesoporphyrin]) and standard extracellular (gadopentetate dimeglumine) magnetic resonance (MR) contrast media.
MATERIALS AND METHODS: Echo-planar (for T1 measurement) and spin-echo (for infarction size) MR imaging were conducted in 32 rats subjected to reperfused reversible (n = 16) and irreversible (n = 16) myocardial injuries. All animals received gadopentetate dimeglumine 1 hour after reperfusion and underwent imaging. Sixteen rats received mesoporphyrin at 2 hours, the other 16 rats received gadopentetate dimeglumine at 24 hours, and all animals underwent imaging at 24 hours.
RESULTS: Mesoporphyrin produced prolonged (22 hours) reduction in T1 in irreversibly, but not in reversibly, injured myocardium. The size of the mesoporphyrin-enhanced region (37% ± 4 [SEM] of left ventricular surface area) closely correlated with the true infarction size as measured by means of histomorphometry (36% ± 3, r = 0.90). The size of the gadolinium-enhanced region overestimated (48% ± 2 and 43% ± 1 at 1 and 24 hours of reperfusion, respectively) the size of true infarction (36% ± 3, P < .05, r = 0.02), but it was close to the size of the area at risk (r = 0.93).
CONCLUSION: The sizes of hyperenhanced regions displayed by using mesoporphyrin and gadopentetate dimeglumine differed from each other. The difference in size of the hyperenhanced region demarcated by mesoporphyrin and gadopentetate dimeglumine may provide an estimation of potentially salvageable myocardium.
Index terms: Gadolinium • Heart, MR, 51.121411, 51.121413, 51.121416, 51.12143, 51.12144 • Magnetic resonance (MR), contrast agents, 511.12143 • Magnetic resonance (MR), echo planar, 511.121416 • Magnetic resonance (MR), inversion recovery, 511.121413 • Magnetic resonance (MR), perfusion study, 511.12144 • Myocardium, infarction, 511.771 • Myocardium, MR, 511.121411, 511.121413, 511.121416, 511.12143, 511.12144
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