Radiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Herskovits, E. H.
Right arrow Articles by Gerring, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Herskovits, E. H.
Right arrow Articles by Gerring, J. P.
(Radiology. 1999;213:389-394.)
© RSNA, 1999

Neuroradiology

Is the Spatial Distribution of Brain Lesions Associated with Closed-Head Injury Predictive of Subsequent Development of Attention-Deficit/Hyperactivity Disorder? Analysis with Brain-Image Database1

Edward H. Herskovits, MD, PhD, Vasileios Megalooikonomou, PhD, Christos Davatzikos, PhD, Anita Chen, MS, R. Nick Bryan, MD, PhD and Joan P. Gerring, MD

1 From the Division of Neuroradiology (E.H.H., V.M., C.D.), the Department of Biostatistics, School of Public Health (E.H.H., A.C.), and the Department of Psychiatry, Bayview Medical Center (J.P.G.), Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287-7619; and the Department of Diagnostic Radiology, National Institutes of Health, Bethesda, Md (R.N.B.). From the 1998 RSNA scientific assembly. Received September 22, 1998; revision requested November 24; revision received February 24, 1999; accepted June 8. Supported in part by National Institutes of Health grant R01 AG13743-03 and by an Engines for Innovation grant from Illustra. Address reprint requests to E.H.H. (e-mail: ehh@jhmi.edu).

PURPOSE: To determine whether there is an association between the spatial distribution of lesions detected at magnetic resonance (MR) imaging of the brain in children after closed-head injury and the development of secondary attention-deficit/hyperactivity disorder (ADHD).

MATERIALS AND METHODS: Data obtained from 76 children without prior history of ADHD were analyzed. MR images were obtained 3 months after closed-head injury. After manual delineation of lesions, images were registered to the Talairach coordinate system. For each subject, registered images and secondary ADHD status were integrated into a brain-image database, which contains depiction (visualization) and statistical analysis software. Using this database, we assessed visually the spatial distributions of lesions and performed statistical analysis of image and clinical variables.

RESULTS: Of the 76 children, 15 developed secondary ADHD. Depiction of the data suggested that children who developed secondary ADHD had more lesions in the right putamen than children who did not develop secondary ADHD; this impression was confirmed statistically. After Bonferroni correction, we could not demonstrate significant differences between secondary ADHD status and lesion burdens for the right caudate nucleus or the right globus pallidus.

CONCLUSION: Closed-head injury–induced lesions in the right putamen in children are associated with subsequent development of secondary ADHD. Depiction software is useful in guiding statistical analysis of image data.

Index terms: Attention-deficit/hyperactivity disorder, 10.43 • Brain, injuries, 10.43 • Brain, MR, 10.121412 • Children, central nervous system, 10.43 • Images, analysis, 10.12149 • Images, display, 10.12149




This article has been cited by other articles:


Home page
 J Child NeurolHome page
K. K. S. Voeller
Attention-Deficit Hyperactivity Disorder (ADHD)
J Child Neurol, October 1, 2004; 19(10): 798 - 814.
[Abstract] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B Toone
Attention deficit hyperactivity disorder in adulthood
J. Neurol. Neurosurg. Psychiatry, April 1, 2004; 75(4): 523 - 525.
[Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
F. X. Castellanos, W. S. Sharp, R. F. Gottesman, D. K. Greenstein, J. N. Giedd, and J. L. Rapoport
Anatomic Brain Abnormalities in Monozygotic Twins Discordant for Attention Deficit Hyperactivity Disorder
Am J Psychiatry, September 1, 2003; 160(9): 1693 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
C. Davatzikos, D. Liu, D. Shen, and E. H. Herskovits
Spatial Normalization of Spine MR Images for Statistical Correlation of Lesions with Clinical Symptoms
Radiology, September 1, 2002; 224(3): 919 - 926.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
E. H. Herskovits, J. P. Gerring, C. Davatzikos, and R. N. Bryan
Is the Spatial Distribution of Brain Lesions Associated with Closed-Head Injury in Children Predictive of Subsequent Development of Posttraumatic Stress Disorder?
Radiology, August 1, 2002; 224(2): 345 - 351.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. R. DeLong
Mid-gestation right basal ganglia lesion: Clinical observations in two children
Neurology, July 9, 2002; 59(1): 54 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Stat Methods Med ResHome page
V. Megalooikonomou, J. Ford, L. Shen, F. Makedon, and A. Saykin
Data mining in brain imaging
Statistical Methods in Medical Research, August 1, 2000; 9(4): 359 - 394.
[Abstract] [PDF]