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(Radiology. 1999;213:603-607.)
© RSNA, 1999

Technical Developments

MR Angiography with Superparamagnetic Iron Oxide: Feasibility Study1

Stephan A. Schmitz, MD, Thomas Albrecht, MD and Karl-Jürgen Wolf, MD

1 From the Department of Radiology, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12 200 Berlin, Germany. Received April 29, 1998; revision requested July 6; final revision received January 4, 1999; accepted April 30. Address reprint requests to S.A.S. (e-mail: s.schmitz@medizin.fu-berlin.de).

Magnetic resonance (MR) angiography with blood-pool superparamagnetic iron oxide (SPIO) particles was evaluated in the whole-body vascular system. In 12 adult patients, three-dimensional fast imaging with steady-state precession was performed in successive steps from the lungs to the calves before and after a standard dose for liver imaging (15 µmol of iron per kilogram of body weight) of AMI-25. On SPIO-enhanced MR angiograms, visualization of the pulmonary arterial, whole-body, and lower extremity venous systems was graded as good or sufficient in all patients, and femoral vein thrombosis was clearly demonstrated in one patient.

Index terms: Abdomen, MR, 95.12942, 95.12943 • Extremities, MR, 92.12942, 92.12943, 93.12942, 93.12943 • Iron • Magnetic resonance (MR), vascular studies, **.121422 • Thorax, MR, 56.12142, 56.12143, 94.12942, 94.12943




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